ID A0A094HGU8_9PEZI Unreviewed; 808 AA.
AC A0A094HGU8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Peptidase M28 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V501_03155 {ECO:0000313|EMBL:KFZ14610.1};
OS Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ14610.1, ECO:0000313|Proteomes:UP000029315};
RN [1] {ECO:0000313|EMBL:KFZ14610.1, ECO:0000313|Proteomes:UP000029315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ14610.1}.
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DR EMBL; JPKD01001093; KFZ14610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HGU8; -.
DR STRING; 1420914.A0A094HGU8; -.
DR HOGENOM; CLU_005688_2_0_1; -.
DR Proteomes; UP000029315; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000029315};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 213..292
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 406..593
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 681..805
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 88827 MW; E9E2F31EE4B01366 CRC64;
MHLLPSPSRQ GHLPAAMAPD DRTPLLGASS TAQPARLPQQ QSSAAVRRRF AYIAAGSLAI
AFVILVLIPA AFIPHLLDDL VPSRGKFQYA DLENLLLNSP STEKLSEWSK YYTSGPHLAG
TNLSQAVWTQ ERWKEFGIED SSVVPYEVYL NYPLGHRLAL LEKPSKGHSK DDEATWKVKF
EASLEEDVLE EDPTTGASNR IPTFHGYSAN GNVTARYVYV NYGTYHDFED LIKANVSLEG
NIAIARYGHV FRGLKIKRAQ ELGMVGAVLF TDPGDDGTPL HDMSENYPDG PGRNPSSVQR
GSAQFLSMGP GDPTTPGYPS KPGVPRSPTD DNIPRIPSIP ISYTDAIPIL KALNGHGPVP
KDLNKYWNVN LGLVTRGVHY NAGPSPEGLV LKLVNEQDYK ITPIWNVIGI INGTLSDEVV
VVGNHRDAWI VGGAGDPNSG SAAMMEVIRG FGQALSKGWK PLRTIVFASW DGEEYGLVGS
TEWVEEYIPW LSEANVAYVN IDVGCSGPKF VAAASPLLNN LIYEVTGRVQ SPNQTVEGQT
VRDVWGGHIS TMGSGSDFTA FQDFAGISSI DIGFTASEES AVYQYHSNYD SYHWMETYGD
PGWHYHATIS KVLGLFVAKL ADSPLVPFRT TDYGTALISY VQQIQDLVDN GPARSSTIRF
RPTPEASTDS ASRHKHLGRG LKHMQGSAHR FLEAARVFDE HVDKLRERAE HGYGWLRWCA
RLKLYLAVRK ANFAMKLLDR KFLHAPGLTG RSWFKHVIFA PGLWTGYAGA VFPSLAEAID
NEDGMGAIGW MQIINDKIIE ATRSLELY
//
