ID   A0A094HI84_9PEZI        Unreviewed;       701 AA.
AC   A0A094HI84;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   13-SEP-2023, entry version 35.
DE   RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN   ORFNames=V502_05982 {ECO:0000313|EMBL:KFZ14622.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ14622.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ14622.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU003435};
CC       Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ14622.1}.
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DR   EMBL; JPKE01002277; KFZ14622.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094HI84; -.
DR   STRING; 1420915.A0A094HI84; -.
DR   MEROPS; M03.009; -.
DR   HOGENOM; CLU_001805_1_1_1; -.
DR   OrthoDB; 735202at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003435};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU003435};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT   DOMAIN          226..697
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   701 AA;  78362 MW;  705072868499B4DA CRC64;
     MAPAQYRTPP QAPPLFTATT SSLVADAKKL CANSKNVMDI IVGSVKPENA AFETVVLPMA
     VDENEGSLEA RIIGFYQAVS TDKALRDAST EAEKIMDEFA IEASMREDVY KLVEAAFQKG
     AELDPESQRL LEKERKSYIR NGLGLPAGPK RDRFKEIKLR LSQISTDFQK NLNEEDGGIW
     VTREEMAGVP EDVLGGLEKG TGAEEGKLRL SFKYPDLFPT LKFALSAELR QKLFIENENK
     CNVNVPLFKE AIVLRDEAAR LLGYPDHATF RIEDKMAKTP KTVLDFLGDL RTQLAPGGIK
     ETEHLKELKI ADLKSRGLEN TYDGNYYLWD HRFYDRLMVE QEYTIDEQKI AEYFPLESTV
     NSMLNIFESL FGLVFVEIEG EARDALSPTA KRDDIVWHED VKLFSVWDDA GEGGAFSGYL
     YLDLHPRPGK YGHAANFNLQ SGFVAANGTR RYPATALVCN FSKPTADKPS LLKHDEVVTL
     FHELGHGIHD LVGRTQYSRF HGTSVVRDFV EAPSQMLENW CWAPAQLKGL SKHYVSGEAI
     PDELIEKLIS TKHVNDALFN LRQLHFGTFD MAVHTPKTHE EAVGLEISEL YNTLRMQISG
     MKGPEALGQG NAWGNGPATF GHLIGGYDAG YYGYLSSQVY SADMFHSVFA KDPMSAVEGR
     RYRHMVLEKG GSQDEMVTLE AFLGRKPSTE AFYRELGLGG N
//