ID A0A094HP00_9PEZI Unreviewed; 1649 AA.
AC A0A094HP00;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JUN-2023, entry version 32.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=V498_07625 {ECO:0000313|EMBL:KFY85932.1};
OS Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFY85932.1, ECO:0000313|Proteomes:UP000029270};
RN [1] {ECO:0000313|EMBL:KFY85932.1, ECO:0000313|Proteomes:UP000029270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY85932.1}.
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DR EMBL; JPKA01002159; KFY85932.1; -; Genomic_DNA.
DR HOGENOM; CLU_003209_0_0_1; -.
DR Proteomes; UP000029270; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR PANTHER; PTHR43791:SF65; MFS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 238..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..578
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1649 AA; 183146 MW; 1455BED234125188 CRC64;
MAVDSYPDEK STIPSHTKVN NTNSSSVSAS ITDDEIDGAG KEHKNANYGS TEQHIFSDSA
NLGYWSRVYE TAKYEGRHRF DSLLQWDASE EKGLVRKHIF SDSANLGYWS RVYETAKYEG
RHRFDSLLQW DASEEKGLVR KLDLRIMLWV WIVFSSLDLN RRNINRALSD NLLDDLGMNT
NDFNNGQTIY FFTFLAAELP GGLLSKKIGP DIMTPFAVVT WGTISACQCL IKNRTGYYIT
RAVLGFSQGG FIPEMILYLS YFYKSNELPV RISFFYTAIP LTQIIGSLLA GGIMAMRGIA
GLAGWRWLFL IEGLMSIVVG LITFLVMPAS ITETSRILRG KASWLNGKDG WFTPREEGIL
VNRILRDDPT KGDMNNRQHV DLKGLWKALK DVDLWPIYTL GVLAFLPYQP TASYLSLTLK
NLGYSVFEAN VLAIPGFILF FVNVLVVVWV SEKFNERMLI SAWSNIWMFP FFVGLVTIPV
SASPWVRYAL LTGVNGIPYT HAILVGMISR NANSVATRAV STALYNMSYQ FGSIAAANIY
RDSDKPYYYT GNKVLLGLCS ANIAIFVLAK LYYIKRNEAK ERGWNKLKSL LSVGYQLIKG
GESRASGVKI VKLNAQELLH VNAVPRPGCG YVNALEDRVG ALESLLHELN PAGNSDHGAN
NDAVNFGFES PTPAYQDTGS VASPSSDGSH CGGMVAPSQD RRTNYPGPSS LRNSKVLKSA
AEHPSIHFPT PYKPAHVDVQ TEVDGHVIAE CVALFFRWHY PQCMFVDRDK FLLGFLNHSY
TSKNSSRSLE FSICALGALL SPEKPIRDLA GSFYDAAVRS LESGGLLEPQ ESSIQTLTLC
SFYQIGQGNF TQAWMLSGIA FRMCEELNDS SHGNPSTPRD IDSRRRTMIS QVLGRLPVIA
KQTQSTGCKE VERTHSIWYH WLEQNGLLDL EEPETLTDST SPAEKQMELS KIIHDMLLPR
DFSSKGSAQQ PTTRRWTEVA ISELNTRLWG WHSTIPGELR WNRWGSSSDA VIPSIAALHM
LYHISQISLN LPFLLDSQPS WESSQAPNLP KLVSDAVDIC GASVDIVISI LRRFRSQYTL
TKVPLNLVHG GIIAADAILA MMDFCDGERR GSLVKDLYVL DDALLEMSYS WNIATTARTG
LKNLLAEKTS SQATITGLSA PPKQPTTFDL EAFAYQPFTP LSLGSEDGIQ LSGLAFPEMF
SAGVSDASSS DMWDLNFPEK GFSFDDSTFL RLSFLPTLRS AVFQTSQFAF KMLSRNLLFL
ASLLAPAAAT GLGPDADGKY TISSKGLRAQ FVAYGASISN LFLKDAEGRE RDIVLGFDNA
TYYAEDPRHS HWGSVPGRYA NRIKNSTFDI DGVTYNILPN EHPTPEHPDG VNTLHGGPNG
WDYREFNVSA QTSNSITFTI TDEDGNQGFP GEVISYITYT LNDMTWDITI VAHSTTKKTP
IMLSSHTYWN LDGFQNPETG TILNHSLWLP HSGQRIGVDS ILIPDGTILP NKPGSVNDFW
SAPKQLGANL TNPDLVGNCG EGCTGYDNCY LVNRGQDGPY DWRSKPVAVL GSPWSGIQID
VFSEQEAFQI YTCNDYNSSL PVKSTQGTDV RRSVPAYGCI VMEVQDWIDA INQPEWQRSK
KQIYGPSDDP YVLRAKYVFS AEKKKHHGL
//
