ID A0A094HTC9_9PEZI Unreviewed; 1208 AA.
AC A0A094HTC9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=V502_07511 {ECO:0000313|EMBL:KFZ11511.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ11511.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ11511.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ11511.1}.
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DR EMBL; JPKE01002696; KFZ11511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HTC9; -.
DR STRING; 1420915.A0A094HTC9; -.
DR HOGENOM; CLU_002472_1_0_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308}.
FT DOMAIN 1044..1060
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..183
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 134082 MW; CCD5AD367258B023 CRC64;
MAKSEKSTTT PSRPAPARKQ GSSAAPSTSK NQRSILGFFS KTPTAGLPLL KKQASPPATL
ESAQTDGAVA RTPVEKAVGK VGKGVKKMDR TPVASSDVIE PPSSQGEGDK NGVLQSSPSR
RAKKPLSYAE PDEDDEDDEA PTTARRNKSK KKVIESDDDD EDVFVGEVDD ASDDDDMDDF
IASEDSDAAP SKSKKRKRPS PSKTPSRKRS YAPSPLPPVE DDVEMGDSQG SSALRWKYDP
DNTKPLQPRS SNITRKPKPT SGEPAKKQKA SKTEPEHRYT WLANLLDMDR NPPDHPDYDP
RTVYIPPNAW TGFSAFEKQY WQIKQKFWNT IVFFKKGKFY ELYENDATIG HQLFDLKLTD
RVNMRMVGVP ESSLDHWANQ FVAKGYKIAR VDQMESALGK EMREREDSVG GAKAKKVDKI
IHRELACVLT KGTLVEGSML EDDMATYCVA IKETTSTADD LPTFGIAFVD TATGQFFLSE
FVDDVDLTKF ETFVAQTRPQ ELLLEKSCIS VKALRILKNN TSPTTIWNYL KTGKEFWGAD
ATKRELDCSG YFLTEEPGAD EEWPATLTEA KEKEVIMSAF GALVQYLRSL KLDRDLLSQR
NFAWYNPIQK STTLVLDGQT LINLEIFSNT YDGGQAGTLF KMLNRCITPF GKRMFRQWVC
HPLADARKIN ERLDAVDMLN ADSTLREQFT GQMTRMPDLE RLISRIHAGV CRPDDFVRVL
EGFEQIEYTM SMLGAFGGGD GIIDRLISGM PDLVGPLEYW KTAFDRTKAR DERLLVPERG
IEEDFDDSED RILGIKQELS GLRKEWAAKL GAKGVQFKDV GKEIYQLEVP VKNSKAVPKD
WTMVSSTKAE KRYYFPELKT LVRALQEAQE THGQIVKATA GRFFQRFDKD YPTWLTAVNI
IAQLDCLISL ARASAGLGSP SCRPTFVDTE RTVVDFTELR HPCVLPNVTD FIPNSIRLGG
SEPNINLLTG ANAAGKSTIL RMTCIAAIMA QIGCYVPAES ATLTPIDRIM SRLGANDNIF
AAQSTFFVEL SETKKILAEA TPRSLVILDE LGRGTSSYDG VAVAQAVLHH VATHVGAIGF
FATHYHSLAA EFAGHPEIAP RRMAIDVDEA ERRVTFLYRL EEGVAQGSFG MHCASMCGIP
RKVVERAEVA AKEWEHTSRL TEGLEVAKRG AYVPLGWQSD IAWMLKKGVL GEGADRGVEV
LMKAIAGI
//
