ID A0A094HX13_9PEZI Unreviewed; 608 AA.
AC A0A094HX13;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V502_06926 {ECO:0000313|EMBL:KFZ12791.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ12791.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ12791.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ12791.1}.
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DR EMBL; JPKE01002527; KFZ12791.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HX13; -.
DR STRING; 1420915.A0A094HX13; -.
DR HOGENOM; CLU_005431_2_0_1; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308}.
FT DOMAIN 108..234
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 350..582
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 68680 MW; B2561126E8F436F6 CRC64;
MPMFQTPQMS SRPIPTRQKV NSDTIQVFQE KADVPTTGQT RLSEGQLESN TTTIATPQAD
DENDTPEKKR SGGGAPSNLD EESEIDSSPR YSDDIPILQR SDEVTPDRHV KVSGFAFDEL
VDRLLSQPMS KADANFTDIF LCMYRKFASP GMLLSAILSR LEKSADEKGQ HFLTRTTVQL
RIVAVLTKWI SQYPGDFAAP QTNQRFSAFV EQISTEPAFN YAVQEMRSML RFHVVEDDDT
RWEKSDIEID SDLEETNELA PVISSTHSSR STDASKNASH SSLADEKNSR RDRRHSETVS
VSSSEAALAA GGQPSAFHTV RDYELEAATF VPSKKHLLTK LLYHNCMEIS DDNFADEITR
IDWIMFSSVR VRDLVRDVSL SAKQKAKCKS LINVTRAINH FNHVAWWVTN LILLRDKAKH
RAQILEKFMR IAWKLRQMNN YNGLAAVMAG IQNTAVGRLA QTQALISEEC RRQFMRLEIL
MGRQRSHFAY RLAWQNSTLP RIPYVPLSRR DLASADEGSK TFVGPKGDRI NWSKFEVFGG
VILPIMKSHS TPVNLEKHDN AREMILDCFI SADEDVGDIP AKLITRGFHL KSRSKEEVSL
VSKFQSIG
//
