ID A0A094HZ38_9PEZI Unreviewed; 628 AA.
AC A0A094HZ38;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=tRNA-intron lyase {ECO:0000256|ARBA:ARBA00012573};
DE EC=4.6.1.16 {ECO:0000256|ARBA:ARBA00012573};
GN ORFNames=V502_03073 {ECO:0000313|EMBL:KFZ20680.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ20680.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ20680.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-
CC half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with
CC a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.; EC=4.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00034031};
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
CC -!- SIMILARITY: Belongs to the tRNA-intron endonuclease family.
CC {ECO:0000256|ARBA:ARBA00008078}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ20680.1}.
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DR EMBL; JPKE01001197; KFZ20680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HZ38; -.
DR STRING; 1420915.A0A094HZ38; -.
DR HOGENOM; CLU_468620_0_0_1; -.
DR OrthoDB; 9662at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000213; F:tRNA-intron endonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR CDD; cd11371; RNase_PH_MTR3; 1.
DR CDD; cd22363; tRNA-intron_lyase_C; 1.
DR Gene3D; 3.40.1350.10; -; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR InterPro; IPR006677; tRNA_intron_Endonuc_cat-like.
DR PANTHER; PTHR13070:SF0; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34; 1.
DR PANTHER; PTHR13070; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF01974; tRNA_int_endo; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF53032; tRNA-intron endonuclease catalytic domain-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 42..205
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 536..606
FT /note="tRNA intron endonuclease catalytic"
FT /evidence="ECO:0000259|Pfam:PF01974"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 67853 MW; 01A80AC928480499 CRC64;
MADRRRINGP SCGTAPPLFT SGDVSSPETN SRLARTRPPN AIRKIFLKTG VTPSASGSAY
LECESQPKSS TPKLSSLSSS GLKISCTVHG PRPLPRSAPF SPHVVLAAHV KYAPFATRKR
RGYQRDPGER DLAMHLETAL RGVIIGDRWP KSGVDVVITI LEGEEDQWWE DDNQAELGPA
GQWGMMNVLS GCITVASAAI SDAGIDCVDM VSGGVAAVVR DRELQVSAKS GTLLQPTLVL
DPVPSEHSEI LAACVVGYLP SRDEITDLWA TGEFDTGYSE DGHSSYDSLS ENAIEAAKGS
YRVLDAALKE NKFLTITHLN MTSGSAMINE PVPISRIAGR YLVFDINVVT YLRRTHHICG
VLIGSIPQVP QQNVFLGLPV ELLPEEARLL VEKEVAYIVD DASQHRETFS TLVGDDRRRY
LDSLRSQGRM SRRAAEEVSQ KKIEKGLAKQ ALLRASKDTL QSTVSKSSTE PTDVTSFSNS
SPSEESLFPD HPSLPTASTP SVPSSASYAV TTTTTSSVLP LSQGHIQQPD PVVPASYALF
CHLHALDYFM TPGLRFGCDY TVYPGDPLRF HSHFLAVGHD WEEEIPLIDL VGGGRLGTGV
KKGFLIGGEG PGSQGNTVRP FCIEWGGM
//