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Database: UniProt
Entry: A0A094HZ38_9PEZI
LinkDB: A0A094HZ38_9PEZI
Original site: A0A094HZ38_9PEZI 
ID   A0A094HZ38_9PEZI        Unreviewed;       628 AA.
AC   A0A094HZ38;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=tRNA-intron lyase {ECO:0000256|ARBA:ARBA00012573};
DE            EC=4.6.1.16 {ECO:0000256|ARBA:ARBA00012573};
GN   ORFNames=V502_03073 {ECO:0000313|EMBL:KFZ20680.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ20680.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ20680.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-
CC         half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with
CC         a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.; EC=4.6.1.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00034031};
CC   -!- SIMILARITY: Belongs to the RNase PH family.
CC       {ECO:0000256|ARBA:ARBA00006678}.
CC   -!- SIMILARITY: Belongs to the tRNA-intron endonuclease family.
CC       {ECO:0000256|ARBA:ARBA00008078}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ20680.1}.
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DR   EMBL; JPKE01001197; KFZ20680.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094HZ38; -.
DR   STRING; 1420915.A0A094HZ38; -.
DR   HOGENOM; CLU_468620_0_0_1; -.
DR   OrthoDB; 9662at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000213; F:tRNA-intron endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IEA:InterPro.
DR   CDD; cd11371; RNase_PH_MTR3; 1.
DR   CDD; cd22363; tRNA-intron_lyase_C; 1.
DR   Gene3D; 3.40.1350.10; -; 1.
DR   Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR   InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR   InterPro; IPR006677; tRNA_intron_Endonuc_cat-like.
DR   PANTHER; PTHR13070:SF0; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34; 1.
DR   PANTHER; PTHR13070; TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED; 1.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF01974; tRNA_int_endo; 1.
DR   SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   SUPFAM; SSF53032; tRNA-intron endonuclease catalytic domain-like; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          42..205
FT                   /note="Exoribonuclease phosphorolytic"
FT                   /evidence="ECO:0000259|Pfam:PF01138"
FT   DOMAIN          536..606
FT                   /note="tRNA intron endonuclease catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01974"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   628 AA;  67853 MW;  01A80AC928480499 CRC64;
     MADRRRINGP SCGTAPPLFT SGDVSSPETN SRLARTRPPN AIRKIFLKTG VTPSASGSAY
     LECESQPKSS TPKLSSLSSS GLKISCTVHG PRPLPRSAPF SPHVVLAAHV KYAPFATRKR
     RGYQRDPGER DLAMHLETAL RGVIIGDRWP KSGVDVVITI LEGEEDQWWE DDNQAELGPA
     GQWGMMNVLS GCITVASAAI SDAGIDCVDM VSGGVAAVVR DRELQVSAKS GTLLQPTLVL
     DPVPSEHSEI LAACVVGYLP SRDEITDLWA TGEFDTGYSE DGHSSYDSLS ENAIEAAKGS
     YRVLDAALKE NKFLTITHLN MTSGSAMINE PVPISRIAGR YLVFDINVVT YLRRTHHICG
     VLIGSIPQVP QQNVFLGLPV ELLPEEARLL VEKEVAYIVD DASQHRETFS TLVGDDRRRY
     LDSLRSQGRM SRRAAEEVSQ KKIEKGLAKQ ALLRASKDTL QSTVSKSSTE PTDVTSFSNS
     SPSEESLFPD HPSLPTASTP SVPSSASYAV TTTTTSSVLP LSQGHIQQPD PVVPASYALF
     CHLHALDYFM TPGLRFGCDY TVYPGDPLRF HSHFLAVGHD WEEEIPLIDL VGGGRLGTGV
     KKGFLIGGEG PGSQGNTVRP FCIEWGGM
//
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