ID A0A094IDU1_9PEZI Unreviewed; 1116 AA.
AC A0A094IDU1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=V502_00259 {ECO:0000313|EMBL:KFZ25267.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ25267.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ25267.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ25267.1}.
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DR EMBL; JPKE01000097; KFZ25267.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094IDU1; -.
DR STRING; 1420915.A0A094IDU1; -.
DR HOGENOM; CLU_281056_0_0_1; -.
DR OrthoDB; 2419619at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd11061; CYP67-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 655..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..78
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 80..465
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 526..593
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 1116 AA; 125163 MW; 4338BB6F558AF654 CRC64;
MSAYNVADEP DIDDIPKNIE EYRMIYEKSI KDPESFWAGK ARKLLDWYQD FKTIRTGNFR
DGDNAWFQEG RLNASYNCID RHATHNPEKV AVVFEADEVN NGRKITYSQL LHDTCRLSYV
LKDLGVKKGD IICIYLPNIY EALIAMLACS RIGAVHSVVF MGFSAAALRD RILDGRSKIV
ITADEGRRGG KAVPTKAIVN EALLQCPLVT SCLVLKHTGS SVPWCPSRDV WWHEEARQWP
AYIAPESMSA EDPLFLLYTS GSTGKPKGLM HTTAGFLLGA NITTKYVFGM QNTDVHFCAG
DIGWITGHTY LVCGPLLVGA TTVVFEGTPA YPSFSRYWDI VEEHHVTHFY AAPTALRILK
RAGDSHITVP MENLRVLGSI GEPIAPEVWK WYYETVGRKR AYIVDTYFQT ETGCHVISPL
VGSIPTKPGC CTVPFLGIET VILDPILGHE LDGPAEGLLA IKRPWPSMAR TVWRAHERYM
DTYFNEFPGY YFTGDGAFRD EDGYYWIRGR VDDVVNVSGH RLSTAEIEAS LLESPYVAES
AAVGVKDEIS GQAVVAYISQ KDANTDAATI SAALIHQVRK DIGAFAAPKA FRIPKNPHPP
HNRAHPLHSS AARGPCRFLL STAMNCLQSL TARAAAFAAG VATHAVGFRH GEWDLVTISL
IWTFIVLHTS AIAALLYLSP GAAVTPLNAV SVVGALGLSS CLGIWTSMLV YRGFFHRLCR
FQGPFLARFS NFYVTFLSAR RLHLYEEVYH LHKKYGDVVR LGPSELSISN ADAVTAIHGP
QSKCTKGPWY NALHPRISLQ LIRDKSEHTR RRRVWDQGFS AKALREYEPR VTAYTDELLS
HFSNSEGKPI NVTDWFNFYS FDVMGDLAWG KSFGMLQHGE KHYFMKSLHA DMKNVGLFSH
LLWLFPIFKA VPILNYEHKR FWKWVHAQVN ERKEMTPDRP DVFSWLLEDF NSRKPTYQDE
LNLNGDAYLI AVAGSDTTAA SLTCLFYQLS LHPECLSILQ KETDEGFEGS EGVDTALLGK
LSYLNFVINE SLRLHPPVPS GVQRMTPPQG LTVGEMFIPG NTIVQIPSHT LYRDERYFER
PDEFLPERWT THPELVKNAA VFAPFSTGKY RLGIGQ
//
