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Database: UniProt
Entry: A0A094L5W3_9AVES
LinkDB: A0A094L5W3_9AVES
Original site: A0A094L5W3_9AVES 
ID   A0A094L5W3_9AVES        Unreviewed;      1891 AA.
AC   A0A094L5W3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 17.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=N338_11101 {ECO:0000313|EMBL:KFZ64872.1};
OS   Podiceps cristatus (great crested grebe).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Podicipediformes; Podicipedidae;
OC   Podiceps.
OX   NCBI_TaxID=345573 {ECO:0000313|EMBL:KFZ64872.1, ECO:0000313|Proteomes:UP000053854};
RN   [1] {ECO:0000313|EMBL:KFZ64872.1, ECO:0000313|Proteomes:UP000053854}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N338 {ECO:0000313|EMBL:KFZ64872.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KL272839; KFZ64872.1; -; Genomic_DNA.
DR   Proteomes; UP000053854; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053854};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFZ64872.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053854};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    281    308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    650    674       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    686    707       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    769    797       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    856    882       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1108   1126       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1147   1166       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1222   1250       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1372       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1430   1448       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1460   1478       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1490   1510       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1547   1575       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1651   1674       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        9    315       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      395    608       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      659    886       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      896   1102       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1106   1380       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1429   1684       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      305    350       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFZ64872.1}.
FT   NON_TER    1891   1891       {ECO:0000313|EMBL:KFZ64872.1}.
SQ   SEQUENCE   1891 AA;  214754 MW;  E8CFF75078E83BF6 CRC64;
     ILFSLTISTL FSMLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKIIARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPENFTLET NITSQLNSSI
     GENGTLVNST VTPFDWKGYI EDESHFYFLE GQNDALLCGN SSDAGQCPEG YTCVKAGRNP
     NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI
     LAVVAMAYEE QNQATMEEAE QKEAEFQQML EQLKKQQEAA QAAAVAAAAA VTASAESREP
     SAVGEAGGVS ESSSEASKLS SKSAKERRNR RKKRKQKEQS GGEEKDEEDF HKSESEDSIR
     RKGFRLSIEG NRLTYEKKFS SPHQSLLSIR GSLFSPRRNS RTSLFSFRGR AKDVGSENDF
     ADDEHSTFED NDSRRDSLFV PRRHGERRNS NISQASRSSR MLAVFPVNGK MHSTVDCNGV
     VSLVGGPSVP TSPVGQLLPE VIIDKPATDD NGTTTETEMR KRISGSFHVS MDFLEDPALR
     ERAMSIASIL TNTVEELEES RQKCPPCWYK FANIFLIWDC SPHWLKVKHI VNLVVMDPFV
     DLAITICIVL NTLFMAMEHY PMTDEFNNVL SVGNLVFTGI FTAEMFLKII AMDPYYYFQE
     GWNIFDGFIV TLSLVELGLA DVEGLSVLRS FRLLRVFKLA KSWPTLNMLI KIIGNSVGAL
     GNLTLVLAII VFIFAVVGMQ LFGKNYKECV CKIASDCVLP RWHMQDFFHS FLIVFRVLCG
     EWIETMWDCM EVAGQAMCLT VFMMVMVIGN LVVLNLFLAL LLSSFSADNL AVTDDDNEMN
     NLQIAVARMQ KGIDYVKRKA REFIQKAFVK KQKALDEIKP LEDLNNKNSC ISNHTTVELS
     KDHDYIKDAN GTTSGIGTGS SVEKYIIDES DYMSFINNPS LTVTVPIAVG ESDFENLNTE
     EFSSESDLEE SKEKLNLSSS SEGSTVDIGL PAEEQPEAEP EEAQEPEACF TEGCVRRFKC
     CQVSIEEGRG KQWWNLRKTC FKIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM
     LEYADKVFTY IFILEMLLKW VAYGYQTYFT NAWCWLDFLI VDVSLVSLTA NALGYSELGA
     IKSLRTLRAL RPLRALSRFE GMRVVVNALL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG
     KFYYCVNTTT DERFEVDQIN NFSQCEELIK NNQSARWKNV KVNFDNVGFG YLSLLQVATF
     KGWMDIMYAA IDSRDVLQQP KYEDNLYMYL YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK
     KISQDIFMTE EQKKYYNAMK KLGSKKPQKP IPRPGNKFQG MVFDFVTQQV FDISIMILIC
     LNMVTMMVET DDQSKEMENI LYWINLVFIV LFTGECVLKL ISLRHYYFTI GWNIFDFVVV
     ILSIVGMFLA EMIEKYFVSP TLFRVIRLAR IGRILRLIKG AKGIRTLLFA LMMSLPALFN
     IGLLLFLVMF IYAIFGMSNF AYVKREAGID DMFNFETFGN SMICLFQITT SAGWDGLLAP
     ILNSGEPDCD PYKDHPGSSV KGDCGNPSVG IFFFVSYIII SFLVVVNMYI AVILENFGVA
     TEESAEPLSE DDFEMFYEVW EKFDPDATQF MEFEKLSDFA AALEPPLHLP KPNKVQLIAM
     DLPMVSGDRI HCLDILFAFT KRVLGESGEM DALRIQMEDR FMASNPSKAS YEPITTTLKR
     KQEEVSAVII QRAYRRHLLK RTVKQASFIY NKNKTEGGAG QGMKDEILID KLNENSFTEK
     TDITASTAVC PPSYDHVTRP VKEKHEKKDK D
//
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