ID A0A094PIE4_9ACTN Unreviewed; 744 AA.
AC A0A094PIE4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:KGA10767.1};
GN ORFNames=GM46_4975 {ECO:0000313|EMBL:KGA10767.1};
OS actinobacterium acAcidi.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=1504320 {ECO:0000313|EMBL:KGA10767.1, ECO:0000313|Proteomes:UP000029305};
RN [1] {ECO:0000313|EMBL:KGA10767.1, ECO:0000313|Proteomes:UP000029305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Ghai R., Mizuno C.M., Picazo A., Camacho A., Rodriguez-Valera F.;
RT "Key roles for freshwater Actinobacteria revealed by deep metagenomic
RT sequencing.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGA10767.1}.
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DR EMBL; JNSG01000042; KGA10767.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094PIE4; -.
DR PATRIC; fig|1504320.4.peg.999; -.
DR Proteomes; UP000029305; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KGA10767.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KGA10767.1}.
FT DOMAIN 62..161
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 397..458
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 660..734
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 744 AA; 82764 MW; D22B609D312B175E CRC64;
MSTTSRVLPW RRNQSAVNQE LLPLLSAFKQ NHPKASITQV NAAYAMASSA HKHQSRMSGE
LYVSHPLAVA RIVAEIGLDE VSLVAALLHD AVEDTEITLA DVESNFGAEI AGIVDGLTKL
ERLQFDSREA QQAATMRKML VAMARDLRVL IIKLADRLHN MRTIASAPID KQRRVAQETL
DIYAPLAHRL GMQEMKQQLE DLSFAALYPK RYAELDYLVS TRAPERDVYL AKALGQVDGW
LNEVNIKAEL TARGKHLWSL YEKMVQKGRD FDEIFDLMAV RIIVDSVKDC YSALGCIHGH
WKPVVGRFKD YIAMPKFNLY QSLHTTVIGP GGKPIEVQIR SRDMHQRAEW GVASHWSYKD
GIASTDIDWL NRIIDWQDEV SDPRQFLESL KTDLDQDELF VFTPKGRVVS LPVNATPVDF
AYAVHTEVGH SCIGARVNGR LVPLDSLLNS GDTCEVLTST ADEPGPMEEW INSVVSPKAK
SKIKQWFSRE RLEDLVETGR DDLVEQIRHL GMPVQQVLES EAFNLEMSAM NYSDATALFL
AIGEGHVAAD SFANRLSRAF GDGEFGEQLS VGMRFDSAGL DSIQQAGIHV EGLDQSIVRL
SKCCTPVPGD EIIGFIVADR SVNVHRSDCS TAIMAISNNV GRVVDVEWSG NLRGATFVAA
VEVVALDRSR LLRDVANALS EEHVNIVACT TQTGQDRVAK MRFEFEFADP SHLQSVLRTI
KRIDSVYDAY RVMSGEHPAS NLPV
//
