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Database: UniProt
Entry: A0A094YS60_BACAO
LinkDB: A0A094YS60_BACAO
Original site: A0A094YS60_BACAO 
ID   A0A094YS60_BACAO        Unreviewed;       450 AA.
AC   A0A094YS60;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BALCAV_0217055 {ECO:0000313|EMBL:KGA96302.1};
OS   Bacillus alcalophilus ATCC 27647 = CGMCC 1.3604.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1218173 {ECO:0000313|EMBL:KGA96302.1, ECO:0000313|Proteomes:UP000002754};
RN   [1] {ECO:0000313|EMBL:KGA96302.1, ECO:0000313|Proteomes:UP000002754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV1934 {ECO:0000313|EMBL:KGA96302.1,
RC   ECO:0000313|Proteomes:UP000002754};
RX   PubMed=25395643;
RA   Attie O., Jayaprakash A., Shah H., Paulsen I.T., Morino M.,
RA   Takahashi Y., Narumi I., Sachidanandam R., Satoh K., Ito M.,
RA   Krulwich T.A.;
RT   "Draft Genome Sequence of Bacillus alcalophilus AV1934, a Classic
RT   Alkaliphile Isolated from Human Feces in 1934.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGA96302.1}.
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DR   EMBL; ALPT02000068; KGA96302.1; -; Genomic_DNA.
DR   RefSeq; WP_003323478.1; NZ_ALPT02000068.1.
DR   EnsemblBacteria; KGA96302; KGA96302; BALCAV_0217055.
DR   Proteomes; UP000002754; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002754};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002754}.
FT   DOMAIN      146    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      358    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     154    161       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      427    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   450 AA;  50954 MW;  EA9C14FCE3B1ECA4 CRC64;
     MENIHDLWER VLAEIKKKVS EPSYDTWLKS TKASDIQNDA ITITAPNEFA RDWLEDHYSE
     LTSDTIEQLT GARLIPKFVI PEHKSDDDLF LEPIPKKKTV TGANSAAIST KSMLNDKYTF
     NTFVIGSGNR FAHAASLAVA EAPAKAYNPL FIYGGVGLGK THLMHAIGHY VMDHNPDAKV
     VYLSSEKFTN EFINAIRDNK AVNFRNKYRN VDVLLIDDIQ FLAGKEQTQE EFFHTFNALH
     EESKQIVISS DRPPKEIPTL EDRLRSRFEW GLITDITPPD LETRIAILRK KAKAENLDIP
     NEVMLYIANQ IDTNIRELEG ALIRVVAYSS LINQDMNADL AAEALKDIIP NSKPKVVTII
     DIQKAVGEHF QVKLEDFKAK KRTKSVAFPR QIAMYLSREL TDSSLPKIGS EFGGRDHTTV
     IHAHEKISKL LSSDQDLQRK LQEISEQIRS
//
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