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Database: UniProt
Entry: A0A094ZGA5_SCHHA
LinkDB: A0A094ZGA5_SCHHA
Original site: A0A094ZGA5_SCHHA 
ID   A0A094ZGA5_SCHHA        Unreviewed;      4107 AA.
AC   A0A094ZGA5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   07-JUN-2017, entry version 20.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|EMBL:KGB32837.1};
GN   ORFNames=MS3_00994 {ECO:0000313|EMBL:KGB32837.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB32837.1, ECO:0000313|Proteomes:UP000054474};
RN   [1] {ECO:0000313|EMBL:KGB32837.1, ECO:0000313|Proteomes:UP000054474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A.,
RA   Oliveira G., Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E.,
RA   Loukas A., Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J.,
RA   Yang H., Wang J., Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
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DR   EMBL; KL250519; KGB32837.1; -; Genomic_DNA.
DR   RefSeq; XP_012792621.1; XM_012937167.1.
DR   GeneID; 24588778; -.
DR   CTD; 24588778; -.
DR   Proteomes; UP000054474; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054474};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KGB32837.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054474};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3431   3450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3650   3668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3714   3740       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3845   3867       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3905   3928       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3982   4005       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     3197   3225       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     3228   3260       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    3203   3214       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    3238   3249       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4107 AA;  458766 MW;  BF8B0A7BB5127964 CRC64;
     MDLFLPTSSG HTSPLANLVD EFSFTVLVLP GQDPGLVHIG WVTSYFKLAK TSKPDHISGF
     LHNVSSQLQF DTTHGQLHGH SNQNPMLGDT SGSGMQPYAA DLFTVRQAAV CLLESDLTLK
     SAVAERASFM VNLGQLLNQM ATAEDLGKRM SQGLSLTCWV DIASGTLGFD LNGRDSGIRF
     QVEPSTRLFA AVFYRPTVKE AIHFEFGRRN RYTLPITASM LRPPRYTSTV LPHRLRVQAL
     ERVHWARVPP KAIKMFSMKI SELRGWGTSI EYPVSEIAVR LPESDRCFIA LELEEMPELL
     KYHSHTLELY RALCCHDNHN VAHYLTNHVD EYQLLHAMTA ADMPGPLRSG FIDLMLVMHI
     SSHVKLKQVT GKEFIVPMFK TEPKPKKYIF DFDERTGELD GKKINDDGGK EVDEYDFDRI
     PAVEEHISIR PELKTDPHLL IPGADGTGNL PVTPPEKTKE DSAMSTALNI AGTNGLLKLS
     DCPPFPLVKL KLVCLDCLVD SVYKGGSIRD PAGGSYEHLL LPLVKTINCL LVMGVLDQKD
     IHTLLAILDP KSFKASLPLR GDSTYESLLE FHLPESVKLE ICRLLHNLCD LQLRNRVEQV
     VKFASKFVQA LQEDQNFRYM AIKKSNLPSS VAARRTREFR CPASVQMKSL LQIHGPGGPT
     GRSQETQTEP STNETVSGNE EEDDELEDVE TNPCSEEVKE MLRSFHKLLC NKLGVMLPEN
     NESNSGNKSD SDKSADSGFD ESHLHSPLLT HPSDTLSLAS FGPSYPSDEL QTALAHLPLV
     PPDMGHPEEG SGTPPWILKL LWNIIIRNPL TNDSTIEVNE NNEQTSVTQF YHSGKRSLDG
     LIVYTIVKWA KEGFIESLEL IREMFSALHR QYNATEELKN ALEKTYVISG SSQDEVSRLL
     RSLGRVRSLL GVQLGSNEEI LLKNCLWDLM NNKVFFQHPD LTRCLAVHET VMQLMVQTLT
     KATFEQPGGN AISKDAIHSS NQAVITDITV TSVTGSSLPV LHEEGLNSTT GHGSHHQQQQ
     QSQQQRGSAG PTEMVVQCCR FLCYFCRTSR DNQKAMFEHL SYMLENSSML LARPSLRGTC
     PLDVAYSSLM DNNELALALR EKQLEKVAIY LSRCGVQSNA ELLAKGYPDI GWDPVEGERF
     LDFLRFTVWV NGETVEENAN LVVRLLIRRP ECLGPALRGG SKVMKHSTGN TGTDGLEVPP
     GGPDGLHAAS ESTGQLISDT DYQPNLAGGG LLKAMKEGLV MSAQIKLVKM AQEAEAAGLN
     PEEEDLGWRT VLMDYEDANL FTPLPYNFES LPPEDDPDYI DLGAAILTFH SILVNLLGYC
     APDMETVKSE SIRARSILQS LVSMADLEGV LSLRFILPPP KLEVQTNEDG EDEWVDKAGM
     PPGLLPEHKA SVVLFLERVY GISDAATFLR LLENGFLPDL RAATLLDSTV VPDSDMALAL
     NRYLCNSVLP LLTRHTKYLG EEGTTGGLFE ATLQTAYRLS KCRSITNHQR EVVCDFLVAL
     MQQIKPPMMS ALLKKMVSDL RTLSKESVVS LRALTEFYQR CGTYYSSDGW TGGAQSSPGH
     SATSVDDDSG CTSNETGSGA SSGGADNVGS RSGDGETSAS EEERSITAHL FILIFEKLSR
     QPYEPELFSY ALPCLCSIAC ALPPDYSISQ LNAMGQQNDS LGQNVGQSVF TDQMNSLLVP
     GAPKLEANDS LDELVHHDVF RPQPIDTSQV RLPVALNGLI QRFAEHCHDS WALDLIEQGY
     TFGAQVDEVR RTHPNLRSFS QLPTQEQMRY IHPVTDTLKT MLACGWSVDG DENRYRDTPG
     DTKHIRRQTI TSDNLLNYNP SPKDLRGVNV TKEMLNMAER LADNAHNIWA RQKMSDLEAI
     GGGVHQLLVP YDILTDNERK RYRRLTHELI KYLQYNGYRL TVRTGSNSTN TNTNKGNGGT
     SNVRHHDNRN LAPTSRFAYG LLNKLLDYVD SAMSSVREPM PSTRYSTSRS WLSSSQDMKF
     FVKVVLPLVE RYFETQQAYF LDPVAGASID EKKMAATLFC KLFSLLRIKL NTFGHDVKIA
     VSCLQGLVQT IDVKAILKMG TAEDFVRSRI LPFFVNAADD LCVVVRNLDA SRYSHVKGTI
     KRGACSVDYI HMVLLPVLKS MFEHLGKNEC GEYLLVGNVQ VTCYRILNAL YKLGTTSSKH
     ANRQSFVDEL NRHRALIGDC LAALASAFPV AFLEANLNSN NPLSITFNNR GGDYSLEARD
     VLEKLSKTIG DLQSIIKQVE LLAESGATGA SEAPYLIEVT LPMLCSYLPN WWRKGPECMN
     LTSCNDGSNE GGIGQDNKTG NLVPKTKGNT FLSSATGPLT TVTADLMNRV LGSVLQLIQT
     NIDSSHAPWM TRIATRTQPI VANSTADMLG QYFLPVSERL LEHALIVERV EEAYRAEKRA
     GSESVGEREE ELSRLVEILV RNLFAFYPLL IKFVDRHRSA WLKKPTYETQ RLFSAVARMF
     LVWIRATKFK REEENFVSAH EIDRLSLIVP SGGNLTPSIN RSRTHTNGRN ESSSLKNVKK
     AKTGPHTSLT VACIKRLLPV GLSQLGGREQ ELVLCAKRKL IKETLSLTGD RGLEHLMQRE
     SDTAIEAFLN NALDQEGDLD HRTQNWQKLL YKKIDRTIAA TGRHAELATS TRSEIVDKIQ
     ILSKVMHGLY LVDHPPAISK GSWKKLVSSQ RKRAVMACFR MVPLYAMPTH RVMNLFIKGY
     ITEWLDYEES LGVKLIEDVT SGALLKDLSK SNELPSTGGT NEVIAGTVHA IEGVQKSTDT
     ETGTAQDLDM MDSTLELDLS TTNNDPGTSI SSDSNKSASL LQTGSLQTTN SSSSQYTYGQ
     DSSSCQPDPL TQLLTALCRS ASDQAPDDPL YLAYAKIMSK SCSGEDEEEE EENSNEEGSS
     FQEQEEQKQQ LLSEQNRLAE RGAAEMVLLQ LAASKGESTP VAQASIELGI ALLLGGNIDV
     QGRMLDYLMK KKLSGFFTSL AGLTQKCSVL DLDTFERCNK AEGLAVGLSD MEGITNLYDA
     DFTCKIFRFL QLLCEGHNLA FQDYLRTQAG NTVSVNLIIS TVDYLLRLQE SIMDFYWHYS
     NKDTIDESGK NSFVRAIKIG KQVFRSLTEY IQGPCIGNQL ALAHSRLWDA VAGFIYVSAQ
     MQDKLSRDPD QLDLLREFLN LQKELMIMLL SMLEGNVVNG PIAKQMVDTL IESSANVEMI
     LRFFDIFLRM KVITTSEAFL AFDVNGDGWI SHREFRLALE QQKTYSPEEI NYIIACVDNN
     ADGKVDFKEF TERFYNPAED IGFNLALLLT NLSEHVPSDP RLERLIDKAR GVLDVFEPHL
     GRIEITGSNG RIERVYFEIR QQHIDQWEAP QIKESKRSFL HSVVGESGDK EKLECFVNFC
     EDTIFEMQHA QSINGDEADI ALNRVAAFNR LLEITHLAFI GHVLSVIFHC VRPSQLCSTW
     NTLRQMTIPD ILLTILGIIV GLLICVGRFG SHILHLLWYI IVALASDISQ KRSLTYCNSA
     VRAMIPWSID RSSYSKVATI TGSIQHHSSE IDTEQPWWLL SEDQQLLIER ADPVHLATIK
     EEYAITNSAK STHLSHENEK SGGDMSPKPS GNWKNNNNNI ASPNYLTSPN LKKISTSSSA
     PPGTRVPTNV MNTSSPASPM VSQKQEDECK TKFNTRNYVI SLFASNFYRF KISALILAFV
     INFLLLFSKV NQISPNVLGD EDAIGNELGG NDSIDTDTDE ELVEWVSSGD TSSYIGPLIA
     TLAAVHSILS FSTLVAYYYL KVPLVIFKRE KEICRMLEFE GMWISSQPAE DNLRAHWDKL
     VLSTPSFPQM YWDKFVKKKV RNKYSIQYDY DEITKLLGMD KVSSDTETGG TSLSKFFGGI
     DIQYLVWKWG VVFTDISFLY LAVYFAASAF GNLNYFLYAC HLLDVAVSFK TLRTIIQSVT
     HNGKQLVLTV MLTSIVIYLY TVVAFNFFRK FYVKDNDGVP DPKCNDMKTC FIFHLHTGLR
     AGGGIGDEIE APDGDESENY RILFDLTFFF FVIIILLAII QGLIIDAFGD LRDQLEQVKE
     DLESKCFICG IGKEYFDKIP HGFEQHVEKE HNFANYMYFL MHIINKPDTE YTGQETYVWE
     LYQQRCWDFF PIGDCFRKQY EEELQPK
//
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