ID A0A094ZGQ3_SCHHA Unreviewed; 1599 AA.
AC A0A094ZGQ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN ORFNames=MS3_00172 {ECO:0000313|EMBL:KGB32034.1}, MS3_0017865
GN {ECO:0000313|EMBL:KAF1316419.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB32034.1};
RN [1] {ECO:0000313|EMBL:KGB32034.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1316419.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
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DR EMBL; AMPZ02000573; KAF1316419.1; -; Genomic_DNA.
DR EMBL; KL250490; KGB32034.1; -; Genomic_DNA.
DR RefSeq; XP_012791826.1; XM_012936372.1.
DR STRING; 6185.A0A094ZGQ3; -.
DR EnsemblMetazoa; XM_012936372.2; XP_012791826.1; MS3_0017865.
DR OrthoDB; 146204at2759; -.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008318; F:protein prenyltransferase activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1.
DR Gene3D; 2.60.40.1130; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR002088; Prenyl_trans_a.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR Pfam; PF01239; PPTA; 4.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR PROSITE; PS51147; PFTA; 4.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000313|EMBL:KAF1316419.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 707..1003
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 1395..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1599 AA; 182024 MW; 94C59AAD6C49AB85 CRC64;
MHGRVKIIQT AEQERAKKLK KEQISKEFSE ECEKLWLCRE KDDFDEVHLE EIGSLIETSP
DTATLWNYRR EIIMHLIRNF SEDQEKASKL FESELNLTTR CLYSSPKSYT VWYHRSWVMN
NHTSPNWESE LKLCNQALTQ DERNFHCWDY RRFVVSKGSI STELELEFTD SAIGKNMSNY
SAWHYRGELL ASASNASVSS SESLNPQTQL NKKQSQSRFD FSLPSGELDL VHNAIFTDPA
DQSPWFYYWW LLGRGERKVY LRELYISRKL GRFVLVFSSV KLMQTLKDLQ VSIKVFPCDG
TISNSITLTP ELLGGWNSVL DGQLSAVWWL PLNQDLVSRY APDNDRHLYQ CQPWNVVAQV
WIRKANGDGN QEICVNMPEG SANYLSLQCC MDSHQNESLT RVTLDPLRLL NPMILPSHDP
KDLVGELNIV RDLLSFEPKN KWALLTLVSL LRFIRPHNFH EEVKEALNVL VSVDPQRSFY
YEHLRSLYAA LDVLAHAYED QSREVVLHNL DMSCFRNLDW YALMTKIDFS NNSIVRIPDT
FSYLISVLEL NLDDNQLITL CGISRLPSLT NLSVQRNRLC TFESIEDLVY CPSLRVVYIN
GNEVIKLPQL SASKMSGDLE GCCRYSTSKA GMEGLDKATI MNIILENSKG SKFYENELRR
EKALRQQIEQ KLKVIKSLTP AMLKSGELEA DHILKDLGQK RRFSRIIVHV DMDAFYAAVE
IRDQPELRHH PVAVGSNSML STSNYIARRF GVRAGLPGFL GKKLCPQLKI IPCDFVKYTA
ASRVVRSILM EYSVSAGSAR NSCESDNIPF SAVSLDEAYL DITDHLVDRS DFPVERRTFW
PRPAPGAPML VCRCRSRSKH PQSHHLNSSC TDNQSEILID DNSESNSNSC QETDKSSDKL
SVRIIKPKYS DPDLDVCIEC GLLCKSGRRI FGLSAWEAVR EMRFRVFCAT RLTCSAGLGP
NTLIAKIASD WIKPCGQHEI ANTLEAVDKF MQTMPVRKVP GIGHVTERRL DAFGIKTCAD
LIDKRGLLWH VSTKVSMVYY MRIALGHSDD RWLINVKNHF DEKSNKPFGF IDNDSENIVP
SAQGQVELNR KSMSVERTFS DTSDENELMH RCEQLAQMLS TDLKEEHVKG QLITLKMKLD
TFEIRTRSQL LPDYTNHTEI INSFGRELLR EEMVAFKSNT ALNKPLTLRL MGLRMSNLLP
VEMCPQIRQR SVEEAFMFAI TSNNTSPEKN PSTISKILLH TETSIKSHNM ISSPKSVEST
KNRLKKLTKS SQKNDRKKMV GCNSSSLKLT VDYSNKLTNI VIRKNPIYSE VLCMTNTEHG
VDSMLNFTDL EKEGSCLRMS NLLPVEMCPQ IRQRSVEEAF MFAITSNNTS PEKNPSTISK
ILLHTETSIK SHNMISSPKS VESTKNRLKK LTKSSQKNDR KKMVGCNSSS LITQWTKSSS
LTRDNEVSSP SSSISLNLSL EPSLSLLASA SSSNNSTGYF FTCPVCDKDF QFSSEDKFNY
HLDECLNRST ILEVVKETLT DRDYCSTTIS QSNHLNSSSH DIGIRKAKSQ KLEVKQSKNS
NISTTKTMTA TTTTSHGPLD KFIFNSSTVH FDQNYIWNS
//
