ID A0A094ZME3_SCHHA Unreviewed; 770 AA.
AC A0A094ZME3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX35_1 {ECO:0000313|EMBL:KAH9595140.1};
GN ORFNames=MS3_00009878 {ECO:0000313|EMBL:KAH9595140.1}, MS3_04084
GN {ECO:0000313|EMBL:KGB35810.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB35810.1};
RN [1] {ECO:0000313|EMBL:KGB35810.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9595140.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9595140.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9595140.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AMPZ03000001; KAH9595140.1; -; Genomic_DNA.
DR EMBL; KL250718; KGB35810.1; -; Genomic_DNA.
DR RefSeq; XP_012795575.1; XM_012940121.1.
DR AlphaFoldDB; A0A094ZME3; -.
DR STRING; 6185.A0A094ZME3; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:KGB35810.1};
KW Helicase {ECO:0000313|EMBL:KGB35810.1};
KW Hydrolase {ECO:0000313|EMBL:KGB35810.1};
KW Nucleotide-binding {ECO:0000313|EMBL:KGB35810.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633}.
FT DOMAIN 64..238
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 276..470
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 770 AA; 86809 MW; B3269E63157696B3 CRC64;
MNLRFIHPDS EERLGFDLSE EVPEPNEDGG CGSSILQFST SDSFHSVEQQ RQHLPVFTKR
SQFLYLLENS RVLVVTGETG SGKSTQLPQY VYEAGWLDSK SNNFNPFGVT MAVTQPRRVA
ALSLATRVAE EKNWRIGKQV GYIIRFEECW TPNSTVISYL TEGMMIQELL RDPLLTRFRV
IMLDEVHERS LQTDILLGLI KKVLRKRPID LRVIISSATL EAEKFIEYFS KMKIPEVETE
NQGLKLTPVS HLNVEGRQYP VSIFYSLDPV PCYLFAAKET VFRIHETKPL GGDILVFVTG
QNEVSQLVGN LIEEYRNRKE RFLNTQQQSS KTKLPTNYPP LRCLQLHGSL PQHEQLRIFE
RPTRSCRKVI VATNVAEASV TIPGISYVID CGFSRIRAYN PVNGLEALVT IPTSQASARQ
RAGRAGRTRT GQAYRLYTEE AYNKLLPRFT LPESLRVDLS GALLRLKTLG IDRLAQFDWL
DPPPASHVGQ SAERLVALGA LDASSGHLTI PRGLKLAEVS TTCGLDQPST AAALLGACDE
GCSQEIAAIV SLMQIQRIFT VSDYKHTSDR IRRQTFGCQQ GDHLTELNAF VAYENQSKLL
SKSELRTWCR EVGLNERGLA HAVILRDRIG SMFHRLKLPW VKAEPEGNPN PVLRALVRGF
FHQAARLASS GSHYLTVRGD HQLRLHPNCI LYSSTTRWPA YILFTNVFLT PNLDYNNDTK
SNNNNKNDLS STCISGVSVI QPDWLLELAP HYYQFGTDRE HLEHSLGIKK
//
