ID A0A094ZZ53_SCHHA Unreviewed; 439 AA.
AC A0A094ZZ53;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Synaptic vesicle membrane protein VAT-1-like protein {ECO:0000313|EMBL:KGB40225.1};
DE SubName: Full=Type I Polyketide synthase {ECO:0000313|EMBL:KAH9580424.1};
GN Name=VAT1L {ECO:0000313|EMBL:KAH9580424.1};
GN ORFNames=MS3_00009082 {ECO:0000313|EMBL:KAH9580424.1}, MS3_08689
GN {ECO:0000313|EMBL:KGB40225.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB40225.1};
RN [1] {ECO:0000313|EMBL:KGB40225.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9580424.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9580424.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9580424.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR EMBL; AMPZ03000007; KAH9580424.1; -; Genomic_DNA.
DR EMBL; KL251403; KGB40225.1; -; Genomic_DNA.
DR RefSeq; XP_012799983.1; XM_012944529.1.
DR AlphaFoldDB; A0A094ZZ53; -.
DR STRING; 6185.A0A094ZZ53; -.
DR EnsemblMetazoa; XM_012944529.2; XP_012799983.2; MS3_0018333.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08275; MDR3; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR44054; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE; 1.
DR PANTHER; PTHR44054:SF2; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000471633}.
FT DOMAIN 46..408
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 416..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48677 MW; 55103C2A7281AD8C CRC64;
MPEETEVNSG ITENKTVETT ELIKENVIVS EKEIKTYKCV TLGAFGGSKH IRIDMNEVKS
VGKNEVAIDV QACGINFLDI MTRQGLIDQA MKPPFILGSE CTGIISEVGE KVTTYKVGDP
VIVLLDNGAW SERLVLPFIE KANTNQTNST TQSGDVECTE SNEFGKIKSI ILPRPKTLDV
NKAAIISFAY IPAYILTYHI LNVHSGDIVL IFSAGGGVGT ALGQLMKLIP NVTLIGIASK
AKHEKLTKIY DILLEPDQDC VTEIKKLYPN GIDAILDCIS GPDTNKLYGI LKPLGKHIIY
GMSNLVTGDR KNFLNLAKHW FHIERINPLK LHDENLLLGG FSLKSLLFSR DPNQTETNKL
IIDVWNELTK LIDSQKIDPI VDSQWYLDET KEAMLRLQER KNIGKVVLIP KLKEKDAEEA
VENTEKPTTD ETSTNSTAK
//
