ID A0A094ZZG4_SCHHA Unreviewed; 607 AA.
AC A0A094ZZG4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN ORFNames=MS3_08302 {ECO:0000313|EMBL:KGB39847.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB39847.1};
RN [1] {ECO:0000313|EMBL:KGB39847.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; KL251302; KGB39847.1; -; Genomic_DNA.
DR RefSeq; XP_012799605.1; XM_012944151.1.
DR AlphaFoldDB; A0A094ZZG4; -.
DR STRING; 6185.A0A094ZZG4; -.
DR UniPathway; UPA00378; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44395; -; 1.
DR PANTHER; PTHR44395:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC3; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13174; TPR_6; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:KGB39847.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..74
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 217..250
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 335..368
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 369..402
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 440..473
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 607 AA; 68613 MW; 611E38A60BF38044 CRC64;
MAGQLPHFTE FDNPASHAPP LTRRLTHLYL VPVNLGLLIF PSNLCADWTL GSLKLIQGWA
DPRNILTLMA FSFILLLVFI TVNWKTPLHQ GRAVCMALSL MIFPFIPASN LFFPVGFVVA
ERVLYTPSLG FCLLIGLGFE NLIGLKFVQT NTMTSSKSSE VKKVCSFKNG LHSRKYPRIS
MGLVIIAFVC KTVRRNTDWS NEYNLFTSAL KVNPNNAKMW NNVGHSLEAE GKYSEALGYF
RKAVNVQPND MGARINVGRT YVNLGMPDKA EEAYYGALEY FPKPKKGQTY YARVSPKDLM
VFINLANLYI TKSPPRLEDA ATLLRRAISL RSDFVDAYQN YGSVLIKLGR YKEAEEAYRN
ALLYQPKSPD LNYNLGVVLL ESHKKSEGLS YLNTALTYNP QHEPSLFAVA STLGESANPD
DQLRAINIYE HLLKQNFEPI KVHFALGMLQ TDKKNYIKAS KHYQNVIILD PDHKGSLFNL
ALLYRNHLGK PDDARNLALH LIKVHPSHIK SYLLLGDIEL TEKANIKLAK QYFEEALKLD
PKNILAKHNL CVALADEDDL EKSESCLLEA IAMEPKPQNY LLQHLEIIRG RLHSRGKHAY
TKLNNDK
//
