UniProt: A0A095A0T8

Database: UniProt
Entry: A0A095A0T8_SCHHA

LinkDB:  A0A095A0T8_SCHHA 
Original site:  A0A095A0T8_SCHHA

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Ontology (9)   
   GO (9)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (30)   
   InterPro (18)   
   Pfam (11)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (42)   

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ID   A0A095A0T8_SCHHA        Unreviewed;      3254 AA.
AC   A0A095A0T8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-NOV-2023, entry version 39.
DE   SubName: Full=Dynein beta chain, ciliary {ECO:0000313|EMBL:KGB40850.1};
DE   Flags: Fragment;
GN   ORFNames=MS3_09336 {ECO:0000313|EMBL:KGB40850.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB40850.1};
RN   [1] {ECO:0000313|EMBL:KGB40850.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; KL251613; KGB40850.1; -; Genomic_DNA.
DR   RefSeq; XP_012800610.1; XM_012945156.1.
DR   STRING; 6185.A0A095A0T8; -.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 2.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR   Pfam; PF12774; AAA_6; 2.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          658..794
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          1237..1383
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   COILED          1824..1910
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2052..2103
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         3254
FT                   /evidence="ECO:0000313|EMBL:KGB40850.1"
SQ   SEQUENCE   3254 AA;  372795 MW;  DA16260D5C97F6C1 CRC64;
     MKQTVAPLQN NEVANIRRKC AHFDVKQHMY REEFRKMSPF NYSCQNPYEI IDKNHQSLLL
     LENEMSNLLT SASLFEVNVP EFKQIKQCRK ELKLLKILWD YIHLIQTSIH NWTLSPWRTI
     NVEQLDLDCK KFAKDLRGLD KEMRAWDAYI GIEEKVKNML TSLRAVSELQ NPAIRDRHWI
     QLMKATGVKF QMTESTTLMD LLSLNLHEYE DEVRNLVDKS VKEMSMEKVL KEINATWSQM
     TFEQETHSRT NLILLKATEE LIETLEENQV QLQNMMTSKY IAYFLDDVSL WQKRLSTADQ
     VITIWFEVQR TWSHLESIFI GSEDIRKQLP QDSLRFDGID RDFRQLIHEI GDDRNVIKAT
     SRPRLYERLE LIQKDLTLCE KALAEYLETK RLAFPRFYFV SPTDLLDILS NGNIPEQVTK
     HLTKLFDSMA SLKFRPDGNK GNSKIAYHMG AKDGEQVKLS KDVNLDGQVE VWLNKLLDEM
     RATIRYYLSE AVSTYEEKSR DQWLFDYPAQ VSLAGSQIGW TTEVNINFAR LEEGYENALK
     DYNKKQIQQL NALITLLIGE LNSQDRQKVM TICTIDVHNR DVVSKLISQK IDNALSFTWI
     SQLRHRWDEK QQDCFINICD AQFRYAHEYL GNTPRLVITP LTDRCYITLT QSLHLTMSGA
     PAGPAGTGKT ETTKDLGRAL GIMVYVFNCS EQMDYKSIGN IYKGLAQSGA WGCFDEFNRI
     SVEVLSVVAV QVKCIQDAIR DKKKRFNFLG EEISLDPTVG LFITMNPGYA GRAELPENLK
     ALFRPCAMVV PDFELICEIM LVAEGFTDAR LLARKFLTLY KLCKELFDPG RPEDQVLMRA
     LRDFNIPKIV TDDLPVFMGL IGDLFPALDV PRKRDLELEK QVKQAAIDLK LQAEDSFILK
     AIQLQELFAV RHSVFVLGNA GTGKSMVWKT LHRTNLNMKK KPVAVDLDPK AVTNDELFGI
     INPATREWKD GLFSVIMRDL ANLTHDGPKW IVLDGDIDPM WIESLNTVMD DNKVLTLSSN
     ERIPLTPTMR LLFEISHLKT ATPATVSRAG ILYINPQDLG TTPFISSWLA ARELQSEQAN
     LQILFDKYVP PCLEVLRSRF KKITPITEIA HVQMLCYLLD CHLTPETTPP DCPKELYELY
     FVFCAVWAFG GSLFQDQLVD HRVEFSKWWV TEFKSVKFPT NGIVFDYFID PVSKKFELWS
     KKLPVFELDP ELPLQAMLVP TTETTRLRYF LDLLLQRKRP VMLVGNAGTG KTVLVQDTFS
     SFNEDIMITN VPFNFYTTSE MLQRVLEKPL EKKAGRNYGP PGNKRLIYFI DDLNMPEVDT
     YFTVQPHCLI RQHIDHSHWY DRTKLTLKEI NNTQYVACMN PTSGSFTIDP RLQRHFCVFG
     LSFPGQEALK IIYSSILTQH LGLINCSTAL QKFAVNVVDC ALLLHAKVAS IFLPTAIKFH
     YIFNLRDLSN IFQGLLFSTN ECIRQPTDLI RLWMHECERV YSDKLIERED VESFQKILID
     ITKKCFEDID ESILFSKPNM YCHFTQGIGE PKYLPVTNMN DLNKLLNEAL DNYNELNAVM
     NLVLFEDAIS HILRISRILE SPRGNALLIG VGGSGKQSLS RLAAFISSLE VFQITLRKGY
     AITDLKADLA NLYLKAGLKN TGTVFLLTDS QITEEKFLVL INDLLASGDI PELLPDDEVE
     NVINGMRGEV KSQGIQDTRE NCWSYFIDKV RRLLKVVLCF SPVGATLRVR ARKFPAIVNC
     TSIDWFHEWP KEALLSVSRR FLSSIELLPE NIRPSVAEFM SFTHQSVNDI SITYLQNERR
     YNYTTPKSFL EQIQLYENML NQKYTDLVNK MTRLENGLQK LESTSQQVDD LKAKLAAQEV
     ELAQKNEDAN KLLTIVGAET EKVKGEKLFA NQEEEKVAKI KIEVSKKQKD CEVDLAKAEP
     ALLAAQEALN TLNKNNLTEM KSFGSPPAAV INVTAAVMVL LAPDGKIPKD RSWKASKAGI
     MSKVDLFLDN LINYDKENIH ENCLKAVQEY LKDPEFDPEF IRNKSTAAAG LCSWVINIVQ
     FYNIYCDVKP KRDALNAANE ELRQATEKLE TIQKKIKDLE EKLKKLTDEF ETATMEKQKC
     QDEAELTYKT IELANRLVGG LASEKIRWAQ QVKQYKEQAI TLPGDILLTA AFLSYVGCFT
     KRYRTELLDQ HWIPFLKSIN PSIPITDGLD PLDMLIDDAV IAAWNNEGLP SDRMSIENAT
     ILTNAERWPL MIDPQLQGVK WIKTRYATDL KVIRLGSKGY LDQIERAISS GDTVLLENIE
     ESVDPVLDSL LGRKTIKKGR AIRLGDKEIE YSPEFRLILQ TKLANPHYKP EMQAQTTLIN
     FTVTRDGLED QLLASVVSKE RPDLEQLKAD LTRQQNQFKI TLKQLEDSLL ARLSAAEGNF
     LGDYALVENL ETNKRTAIEI VEKVAQAKIT EVQINEAREL YRPAACRASL LYFILNDLNK
     INPMYQFSLK AFRSVFEVAM DRSEASEDIQ TRVKNLLDSI TYSVYMYTSR GLFEKDKLIF
     TAQMTFQILS VSNEIDPVEL DFLLRFPIIP NLTSPVDFIT NNGWGGIKAL SNMEAFRNLD
     KDIEGSAKRW KKLVEGEAPE KEKLPQEWKS KTPLQILCIF RALRPDRMTY AITDFVGQKL
     GQKYTEGGGL SFVKSFEESG PSIPIFFILS PGVDPLKEVE ALGRKLGFTG DNQNFHNVSL
     GQGQEVVASK AMELASKEGH WVVLQNVHLV AKWLPTLEKL MEEAAEKGHA NYRLFVSAEP
     AADPEYHIIP QGILENAIKI TNEPPTGMHA NLHKALNNFN QDTLEMCSRE NEFKTILFGL
     CYFHAVVCER RKFGPQGWNR IYPFNTGDLT ISVSVLYNYL EANSKVPWED LRYLFGDIMY
     GGHITDDWDR RLCKTYLEEY LVPEMLDGDH CLAPNFKTPQ NTDYKGYHQY IDELLPPESP
     YLYGLHPNAE MEFLTNTSEK LFRTIFEMQP RDAGAGSGTG ISREEKLQNV LDEIIEKLPE
     DFNMLELQSK VPPEERTPYV VVAFQECERF NILIKEMRRS LKELTLGLKG ELTTTPEMEE
     LANSLIIDNV PAQWEKRAYP SMYPLGIWYA DMLSRVKELE VWTNDFSLPN TVWLGGLFNP
     QSFLTAIMQQ TARKNEWPLD RMVLQCDVTK KTKDEMSAPP REGAYIYGLF MEGARWDIQT
     NMIAEARLKE LAPSLPVIFL KAIPVDRQDL RNTYACPVYK TKQRGPTYVW TFNLKTKEKP
     SRWILGGVAL LLQV
//

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