ID A0A095A169_SCHHA Unreviewed; 2278 AA.
AC A0A095A169;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Dynein heavy chain 1, axonemal {ECO:0000313|EMBL:KGB39209.1};
GN ORFNames=MS3_07620 {ECO:0000313|EMBL:KGB39209.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB39209.1};
RN [1] {ECO:0000313|EMBL:KGB39209.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KL251154; KGB39209.1; -; Genomic_DNA.
DR RefSeq; XP_012798969.1; XM_012943515.1.
DR STRING; 6185.A0A095A169; -.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF28; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 829..1228
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1357..1651
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1725..1834
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2085..2183
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2232..2278
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT COILED 639..666
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2278 AA; 263964 MW; E3B14A51E1F65460 CRC64;
MKLASKISLK NRRKKRKFQS VSISEELEHK YHIQPNDLMP RFSEKYLVEK NTWTSYLPLE
YFDDEQYDSR TPSDWLALGM DEGVRKPIPA VCLLPVNDHQ QSLDIRSPEI EWKWQLAGVL
DYDVRSKLWF VQKVDSKGRI IDESGEPLVN GGVLSSGKVL ELNTQYWIPR IQLMFLAEDP
QIFAKRVATA FKCRQDHESA LRYNLYLDCM PNEGIGELSS AVLKRMTFLA KDEACTIRNS
KGIDSLLQNL EKEVTFDYWR SMNDLILRRL FEKQETKYHF IQPPGIKKLK TPWKGTLDIP
LYDFDNIFQS FSSKSMLTKP EAIMAIRKCQ YECLEVRSKS IFHVSLSKHM RIEEFEQTQS
MVISQVSIFL KDAWIENLRK HIRACFHDTG KGWFNIYETD FYVYTQSKLK KFMEMMKFCM
QDGLRYLIMD SLINFTNMLR DSCIACLNIP NEYEWTNDLM TSSLLPKKNP IFLVDLLLDT
DGPHYSTSIT QFPNTLIQIF DKAINSVQDV PQIEQYVIEG ITCVEKQLLE AVGLREPQVE
RLRQQCKEYR NLALIPMRAY AKQYERFMEL TILDITAHLK VYESKNLGVL ELKQQIEKYL
QEKETVEQII PSFIIIGPFY VNTEPVRQNL SKKYKALVSA LLELLAKQLR KQADAISEEL
KSIAMKLYEK PNSIEELTDL REWISTVPDK LEERQEYIDK AVSDYELIDL FFYNLSADDF
NAKWTTIGWP HKIRQIIIQV EKNLEEDEER FKKLQISESS SFADKIDTLT MMVSSMASYS
EIGKAQEVAN EVRRIYKQLM DAQNMGGLLN SRERLFGLPN TNYENIPRLL KDFEPFKNLW
LNVADWVKTQ EAVMNDPLIS IDADSVEKVI VECYKTMHKS VRIFHELPNI QELANQVKLS
IEEFKPYLPL IQSLRNPGMR QRHWEQLSEE LGVSIVPKTS LTFSKCLEMH LQDNIDIISK
IADIAGKEYS IESALNKMMN DWESVKFDVI PYKDTGTCII KIADEVNQLL DDHIVMTQSM
NFSPYKKPFE ERISHWENKL HLTQDVLDEW VTCQRQWLYL EPIFNSEDIN RQLPLESKRY
ATMDRIWRKV MKSASEQSQV ITLCPDTRLL NGLRECNRLL EQVQKGLSEY LETKRQAFPR
FYFLSDDELL EILSQTKDPK AVQPHLRKCF ENIAKLQFEK DLQITAMFSG EGECVKFEKT
TYPTSNVEEW MLEIENLMRY SIRTIIGKSI KAYADTPRTD WVLQWPGQII IAVCQTYWTT
EVTEAICTNK MNELYSNLLK QLDGLRNLVR SDLTKIGRMT LSALIVIEVH ARDVVAKIIE
EGVHNVNDFE WISQLRYYWK NDEEQLKLRA VNAEFNYGYE YLGNTTRLVI TPLTDRCYLT
LTGALHLKFG GAPAGPAGTG KTETTKDLGK AFAIQCVVFN CSDQLDFMAM GKFFKGLASA
GAWACFDEFN RIDIEVLSVV AQQITTIQKA QQQHLTRFLF EGDDLELKPS CAVFITMNPG
YAGRTELPDN LKALFRPVAM MVPDYALIAE ISLFSFGFTD ARLLAKKIVT TFKLSSEQLS
TQDHYDFGMR AVKSVISAAG NLKRQNADMD EDLICLRAIR DVNVPKFLLD DLKLFSGIVS
DLFPNINEKP IDYGDLMIAL KTSCSKLGLM EVEGLDLDQS CYEVLQNALT SICKKVAPDG
TLFQTVHTYI LNPKSITMGQ LYGEFNLLTH EWTDGILSTL IRHGDSIRFI RNETKEIITT
TDGQLCFSLM KMMDCFFVPF QSKEKNINTD EMISRVGQAI ESWFLFSLIW SIGATCTNEG
RMKFDRYLRH KMKELKCGLP FPEEGLIYDY RFEDDGLLSL CVKDDEEEDN CVNRKMHWVN
WMINIPEYKI TSDIRYSDII IPTIDNVRSS YIIEMLLLAK KPVLCIGPTG TGKSLNILHK
LTRHMPKEYI PEFIIFSAKT TAKQTQDLID SKLDKRRKHL FGPPLGRYII FFIDDLNMPT
LEVYGAQPPI ELIRQWMDFS GWYDLKMIGE FRKLIDVNFI CSMGPPGGGR NPITARLMRH
FNVLAYNELD DSSMQLIFSV ILKSWLNRST SENVTMKLMS YTDDLVKASI SVYKTIQKQL
LPTPAKSHYT FNLRDLSKVF QGMLMMDTDQ LSGNIEQLLR LWYHESCRVF QDRLVNDVDR
DWFNQLINKT SKEMFNLNVN DYVTTTPLLY GDFLSISKND ASKYMEMTDH SKVLQVIEEN
LDDYNQINTA KMDLILFIYA IQHICRISRI IRQPQGNALL LGMGGSGRQC LTRLASHM
//