ID A0A095A2C3_SCHHA Unreviewed; 1209 AA.
AC A0A095A2C3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Membrane-bound transcription factor site-1 protease {ECO:0000313|EMBL:KGB40987.1};
GN ORFNames=MS3_09481 {ECO:0000313|EMBL:KGB40987.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB40987.1};
RN [1] {ECO:0000313|EMBL:KGB40987.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; KL251672; KGB40987.1; -; Genomic_DNA.
DR RefSeq; XP_012800747.1; XM_012945293.1.
DR AlphaFoldDB; A0A095A2C3; -.
DR STRING; 6185.A0A095A2C3; -.
DR EnsemblMetazoa; XM_012945293.2; XP_012800747.2; MS3_0018327.
DR GeneID; 24596657; -.
DR KEGG; shx:MS3_00009089; -.
DR CTD; 8720; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1094..1114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1126..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..460
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 172
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 216
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 401
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1209 AA; 137079 MW; D5795E72AF2917BE CRC64;
MPSYEYVSSV VETEFIISYY KHSCAQSRHR FLKSILNSFP LNYSIMERWY PPSNAIEKKS
DFDVIKTLNL SRMNVSNFIQ YLSNISQIKS VSPQKQINRV LLNYDINDEE FSHNSNRFDS
RRNLKLFGDS QRYSSPGTLP LDPLKQPWKL LQAEYAWSRG LCGNGVRVGI FDTGLASPDH
KHFSLSNIIE RTDWTVDITN RSYSDDYIEA LDRHGHGTYV TGLIVAQNPN LYYSKFINSF
NKHDDSTCPP WGFAPRADLF IFRVFTDTQI SYTSWFLDAF NYAISRKLHV INLSIGGPDF
LDKPFVDKVL ELSANGILLV SAIGNDGPLF GTLNNPADQM DVLGVGGVDA LGRVARFSSR
GMTGWELPAG YGRVKPDIVT FSTGVISSNL DGKCRVLSGT SVASPIVTGV VSLLINAALN
HNANLINHEN GSLYYMNNVD NYPFVPINPI SIKQALIASA NQLDSVRVFG TNSIKWLQET
DQSSMFEQGA GLVNLQSALE IVQRMKPQAS LMPSYLDLTQ CPYMWPYCSQ PLYSTMQPII
INITILNSMD VVGRIEKPPI YHPYINYNGH RLHVGISYSQ YLWPWVGYLA VYLSVTPDSI
DDIIPSSRFS GVAEGYISLV VESYDNIRNL SLSTNLRLPI KANIVPIPHR SKRILFDQFH
SIHYPSGFIP RDDLTRSKEP LDWLGDHIHT NFLDLYTHLR RKSYFIEVLT STFDCFNASN
YGTFLIIDPE EEFFPYEVEK LFIDVTEKGL SLIVFADWYN TSVMQSLRFY DTNTRRLWTP
DTGGSNLPAL NELLRPFEIE FGDSVFSGNY VIGHRTVAYH SGSSLRKFPN QAIANHSGRT
ALLKVNLVDI GKQFIQHDSM FSKSESETSL EGDKILVNSE PNLRLKPIIG KDPTPAILGL
WTPIVENVVS EMGRLSIYGD SDCLSSTHLS SNCFWLLDAL LQFSTSSMGR IPRILIEQML
TPNTDVWFDS SLTAPSRAKN SQLNLYSNVI KKEWDSSTLN TSYLPLEAYY SVKSCYIAPT
ASISIDKDEP NESFYHPQRL LLYPVELYPS EKLYTTHYCH SFTSILSSDK NSFLISKPKL
LLQSINDFIQ LDLYTSYNVT FICVIILLIV VCYFCKHCIM YFSNSILYVT GWILSMIRYM
LVRILFGLYN LWRVHISDFS KKVFSKVYAT NNSTGSSSTT TAETSRLSPS IVQKISQQNR
CNIHVCVHR
//