ID A0A095AIF3_SCHHA Unreviewed; 2742 AA.
AC A0A095AIF3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=protein xylosyltransferase {ECO:0000256|ARBA:ARBA00011972};
DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972};
DE AltName: Full=Peptide O-xylosyltransferase {ECO:0000256|ARBA:ARBA00042865};
GN ORFNames=MS3_01916 {ECO:0000313|EMBL:KGB33731.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33731.1};
RN [1] {ECO:0000313|EMBL:KGB33731.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-
CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA-
CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132085; EC=2.4.2.26;
CC Evidence={ECO:0000256|ARBA:ARBA00001814};
CC -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004840}.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT
CC subfamily. {ECO:0000256|ARBA:ARBA00010195}.
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DR EMBL; KL250565; KGB33731.1; -; Genomic_DNA.
DR RefSeq; XP_012793500.1; XM_012938046.1.
DR STRING; 6185.A0A095AIF3; -.
DR UniPathway; UPA00755; -.
DR UniPathway; UPA00756; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030158; F:protein xylosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR003406; Glyco_trans_14.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR002889; WSC_carb-bd.
DR InterPro; IPR043538; XYLT.
DR InterPro; IPR024448; XylT_C.
DR PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1.
DR PANTHER; PTHR46025:SF3; XYLOSYLTRANSFERASE OXT; 1.
DR Pfam; PF02485; Branch; 2.
DR Pfam; PF12529; Xylo_C; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KGB33731.1}.
FT DOMAIN 53..150
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 2742 AA; 313538 MW; 6EB452C3DC4A3111 CRC64;
MASYLTYNDI SCIQTTYGCL LRIYLYFRGY TALYSAVCIC FQKSVLVCNL SEQPSFVGCF
LIRHSELNFV KSSEYKDDND CLSICRSLGI AYSWLGPSHT CWCMMQLPNE SRSIPLSQCS
ITCTLEGHGF GPNNDPLCPD PVPVRVYATK ASPPWHPVPL SLKSGLIDLV SSKPVRIVYL
LVWNGRSWPH IRRMFELIYN TRHYYYIHVD AVSNYCLKGI FFRLYGFRCG YLYTMVKSFI
GNYPSNVYLT STRFSPIWGG QSLLDMFLSS LKDLSFNMSD WEWDFVINLS ESDLPISFLR
NQGFGQLFLE CDSYVWHLGE RSVPSGIILD GGSDWMILPK IFVDYVIYSD ANLLRDIKEY
FRYSLLPVES FFHTVAQNTH FCTSVINHYL RFINWKRPQG CGCKYGSVVD WCGCSPLALN
GPKDAELLCE LTGKCLKPDY GLQPLFFARK FDSTIDLGII NFVVYKLLER SDGADAKSSL
LNSFALFNAT GWEEFYHIPS NELLNTWVNK RNIVPPLVIQ IRLTEFTNLS TINDRNHFIV
EFLVHPPSLS FTTVDTISNL LPGDIGFLEI SSNFDVKEQI FRNYPRFLTL QETLTILVLW
KGNSDHKIYK TSVVFTLINP LGIPCLKQLK LPLIQNKHTL RSLAMPELYI TTSLFKNTIL
MNCVQKHVNI VPGEWTIIAV TSSGQISRAK FVLSDPLKLS QSLRLPYKLL ADEKLFDSKS
WNSVQVTDFC IIQQSTKGKS NSLYTNNITF RIFNNFSLER RILQESIYHD IRKYSQEKYG
LDVCVLLGQK YGLPLLPKRI SANIFECIIH RMKQKTCNPY YKVLQAVDLA KWYHLNPNVL
GEPEWNLNSM DYLGDKLENK SFESRKKIIK EWNHERNIIV WIFYYIGNLC LRENLITEQD
FNALVLTEFS HALSLLINST ELHCNGWMNN NGSPINTDWM FSDPIVLQRE IIDIQYYVND
ELNTEKYIDI VPELTPIFGT IFDCQDSDMS KKQSMVDQLL QDNLQVVIKH LIQKIHKSKP
KFEDQKLKVL WRSPNGIDRK FHQDYLSEFV TRFKNLTCDA IDKRARTKVA LMLPNLPIGH
LQLEREETSV PFVESEKNEG MECTLSAPVI TFPQIQNRHT HLAREFQKRI NLWDNVWNSL
NYVGWLIPIA SSYINEIETS LCYLEDTDPT AQVPMLVYST CKTTDKTSEK PFCLANGVAA
CCFQEVQKRL SANSTDCLLL IRIYTNSILI TDVLSDLAEQ ISVVLQTDIG TLKTTTLASF
LYSLSCLQRK HISKSIIIII GGIEHLEVSE YQDSMEGLLP ILQAKQFPRR LASGIKLILS
GNLTMTKLKE NIEESEMGIS DGILLPTTSL NLEVCSKGLS GGFTNCMYNL TKLNHCLTND
QLLSVHQLFQ LISEEKNLPI LACAAGLCIL PDLPSEYIKG NDLVCKLIHT HLNDFISYFG
KYFCHHTVEH LIYLLITVGN EKLNSPGATI HELQEILSLP HELPTNQTSQ QYFENSNTPV
FDNGCLLLLL HSSEKSLTAR LGHQSPICSL DGYFVYKLFT NNQVDPKTMN VVSKMLKSYF
LNEWYEKSKD LFSLKPYSIS FHSVYYTVPR GSNNPKKEGY SCDLRVLNYN VRYLRHLSFC
LLNSKDYYEF SYRTIFFFDW LYGKIYSIGV KPVLNDLQIL IDMLSSLDNQ SNFAENTETV
RFASSVVQNI LTQLSKSLYN NPDSLPTELL GYLIRFTSRF INFGKQMSEL ERISLIDLLV
KQCEMEIVKK SHLLPLYSYP LTPGNPLLGQ ITCATPLLNL RNLNQNNDAP CWKSSSGYLY
LTPNGKYAII IDEEKRDTLK IHQIDIDIDG CVPLIGQINP GLWIKPIWIK HPEKETLNMD
IIFLDITDDY VGFIVQTKNT RSFLNPSEYV DYLDDGDENF HNNIRDCNND TDKNKTKGPI
NKSMSLHHLS ESLSAGTINH VVIFELTTGK PLHLISPTPC ATLVKLVQVS RVNEKESPNV
SIDDNNESIN RSCDLFFINS ADHLLGFHLK SGEQQFSIDL QFVPRKILVS NDNQRLFILD
SSHPCVLQLL INKLGQINKS FRISYDDLIT KDNILDIKLS KYHSFLLIHA KKNVLVYDYE
NDAVFVHITR PTGIPKEFRL PNTKYQSLVF TAVEFALNDQ IVLAAIFRNI LIWDVRLGVQ
LTTLTSSIGV ISRLLVDPSE RQLIGYISTS KILNLWNLPL ALTNAALKQN SDTTPVSFLN
GSNRIDCLTK PINQLIYSNS SNILLVTCHN SDELGVFDLH SGHLTDVFTH NGIVQSVVLS
SCGKYVLIGL SVNNQTEENA NLIWDLSKRL IVVEYGNQVG FHIERTKKNG HFLHLMPELA
LDNNTQGCSY VILQVEIDKT NKEENKASIK PVTSTRLSSI VPGSRPFVTS DDEHLVVQMG
NSDGLKQGAY ICQELAFWSF YSSENESTEQ NGKLWYTHTK ELKTLLTDNT EYDLHILNCA
PIQNESSLVV VIFAKFNDRI KSDLSVDWIT GMGLPKGMLL AEIVKTDQSE LSKEWMLVIL
RSITGLSEWS PFQTLYYSFP KHELYDSTTG QYYILPPGTR HVSHEYFKKH IPHFTVQTKQ
YTNCNPVKFH GYVLNDNLCI FSHHSTIYLV RPALAKIVTF IDVQHTITTI SKNPFSDRSL
FIGTLDGYII SYYITTDDNL NNESTGIQLV LKEAHLNTNS KVTESIGQHL NFYSTQDKMN
DVKYLDPMIH YLPFKHIKPE DFKLYQHCGH FGERRSQTCL LI
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