ID A0A095AJT9_SCHHA Unreviewed; 1260 AA.
AC A0A095AJT9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 {ECO:0000313|EMBL:KGB34301.1};
GN ORFNames=MS3_02502 {ECO:0000313|EMBL:KGB34301.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB34301.1};
RN [1] {ECO:0000313|EMBL:KGB34301.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL250600; KGB34301.1; -; Genomic_DNA.
DR RefSeq; XP_012794066.1; XM_012938612.1.
DR AlphaFoldDB; A0A095AJT9; -.
DR STRING; 6185.A0A095AJT9; -.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08836; ArfGap_AGAP; 1.
DR CDD; cd01250; PH_AGAP; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 563..740
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 809..933
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 316..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1260 AA; 137571 MW; EF09AE5885E512EB CRC64;
MSSQSSLNDI SNAIRQEIIR FESVHPNIYA IYDLIDAVED KNLAESLRQL VVSIEGTVSF
VNQTFCLLDA FVNSQEWTLS NGVPGIKLGL LGSVQSGKSA LVHRYLTGAY VHDESPEGGR
FKKELSLDNQ SHLLLIRDEG GPPDLQFSQW VDGVIFVFSL ENIESYQVVY DYYARLSTYR
SIASLPIILV GTQDSNCEPY VRVIDDARAR KLANDLKRCA YYETCAAYGL NVERVFQDAC
LKILQLRASG NSPVPRPITP QISSNSQQRA CANSPVECVP IVGISQSQQS LFSNVVNARE
GPLLMKNPGV NCNVTNSVTS GVDRKERPVF PNNPSNRRPD THSNPGFELD FNEDSGLHQT
LLHPTKPNLL SIAKHSFTLD FRPSERDNFF ADVKPIRANT CTTDPAEDWA THPFLLDERH
QHPLFRCPEY VPTEYSESIF QSPSPHVYSE YSGKIPYPPS TSDNGVSTPQ PLSAPAASAI
GYSPFIVSPN FPSGTLAAAS SVSSIGLGVE AESKADNNES LTPSSTPTHS RKNRRKSNLF
QKRNEDERER EKKLNGIGSG RAIPLKQGFL YKRTCKPLSK EWKTKKYVTL TDDARLTYHP
SIHDYMDNSH GKEIDLSRTT VKIPGVAFRQ VGSRITSNGL LRSQLNDGGT DRRSTGVDVK
NPTENSAPIN DNSASGGKDS SSVKKRHRRI KSNPKSNNAD GSDSEGYEFQ LISMDRQWHF
EATGPDERDE WVMYIERAIM TRLQLNESSK RTRAIAATGC TTGGGGASGS NHLSNVSGLG
SGSGRHGDSN SLNSSRCGAG DANELAVTEH LIQSIRSAAG NDFCADCGAP EPDWASLNLG
AMVCISCSGI HRQLGTHISR IRSLHLDEWS TESVTVMSAI GNTLANSVWE AAAPVNAGNL
RKPNPSSSRE EKEIWIRAKY QHREFLPPLP YPDAPLQRQL IDAIARQDTR QVILCLALAT
PETVNAAYSL QDPRAAIHIA ATLGNLVYLQ LLLWYNGDPT VTDHEGRNAF YYAHCSKNYD
CADFLLRNSC PKQLVPPIPP NNMPPTIRSS QNIMPQQIVQ SHSIIHGPST STGLSSGVAD
INISNSINSG LVQPHHFSHL QQHQSSAAVV ASEVGTHLSG QLPSYHPMTT GSVTANQQLS
QGSNHPLVSA SGNMYTGNVN QALGATLPRR RAPIGPFPPG AVPPTLQPFP RPNIQQQVSV
SNTHRPTSSV IQSVTRSITP NAMLRTSLVS SSQPPHTRSA SNTAATLSQP YVSTTQEVGL
//