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Database: UniProt
Entry: A0A095AJT9_SCHHA
LinkDB: A0A095AJT9_SCHHA
Original site: A0A095AJT9_SCHHA 
ID   A0A095AJT9_SCHHA        Unreviewed;      1260 AA.
AC   A0A095AJT9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   08-NOV-2023, entry version 44.
DE   SubName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 {ECO:0000313|EMBL:KGB34301.1};
GN   ORFNames=MS3_02502 {ECO:0000313|EMBL:KGB34301.1};
OS   Schistosoma haematobium (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB34301.1};
RN   [1] {ECO:0000313|EMBL:KGB34301.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22246508; DOI=10.1038/ng.1065;
RA   Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA   Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA   Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA   Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA   Wang J., Gasser R.B.;
RT   "Whole-genome sequence of Schistosoma haematobium.";
RL   Nat. Genet. 44:221-225(2012).
CC   -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC       {ECO:0000256|ARBA:ARBA00005430}.
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DR   EMBL; KL250600; KGB34301.1; -; Genomic_DNA.
DR   RefSeq; XP_012794066.1; XM_012938612.1.
DR   AlphaFoldDB; A0A095AJT9; -.
DR   STRING; 6185.A0A095AJT9; -.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd08836; ArfGap_AGAP; 1.
DR   CDD; cd01250; PH_AGAP; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR   PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          563..740
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          809..933
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   REGION          316..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          512..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..704
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          775..795
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1227..1260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..556
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1260 AA;  137571 MW;  EF09AE5885E512EB CRC64;
     MSSQSSLNDI SNAIRQEIIR FESVHPNIYA IYDLIDAVED KNLAESLRQL VVSIEGTVSF
     VNQTFCLLDA FVNSQEWTLS NGVPGIKLGL LGSVQSGKSA LVHRYLTGAY VHDESPEGGR
     FKKELSLDNQ SHLLLIRDEG GPPDLQFSQW VDGVIFVFSL ENIESYQVVY DYYARLSTYR
     SIASLPIILV GTQDSNCEPY VRVIDDARAR KLANDLKRCA YYETCAAYGL NVERVFQDAC
     LKILQLRASG NSPVPRPITP QISSNSQQRA CANSPVECVP IVGISQSQQS LFSNVVNARE
     GPLLMKNPGV NCNVTNSVTS GVDRKERPVF PNNPSNRRPD THSNPGFELD FNEDSGLHQT
     LLHPTKPNLL SIAKHSFTLD FRPSERDNFF ADVKPIRANT CTTDPAEDWA THPFLLDERH
     QHPLFRCPEY VPTEYSESIF QSPSPHVYSE YSGKIPYPPS TSDNGVSTPQ PLSAPAASAI
     GYSPFIVSPN FPSGTLAAAS SVSSIGLGVE AESKADNNES LTPSSTPTHS RKNRRKSNLF
     QKRNEDERER EKKLNGIGSG RAIPLKQGFL YKRTCKPLSK EWKTKKYVTL TDDARLTYHP
     SIHDYMDNSH GKEIDLSRTT VKIPGVAFRQ VGSRITSNGL LRSQLNDGGT DRRSTGVDVK
     NPTENSAPIN DNSASGGKDS SSVKKRHRRI KSNPKSNNAD GSDSEGYEFQ LISMDRQWHF
     EATGPDERDE WVMYIERAIM TRLQLNESSK RTRAIAATGC TTGGGGASGS NHLSNVSGLG
     SGSGRHGDSN SLNSSRCGAG DANELAVTEH LIQSIRSAAG NDFCADCGAP EPDWASLNLG
     AMVCISCSGI HRQLGTHISR IRSLHLDEWS TESVTVMSAI GNTLANSVWE AAAPVNAGNL
     RKPNPSSSRE EKEIWIRAKY QHREFLPPLP YPDAPLQRQL IDAIARQDTR QVILCLALAT
     PETVNAAYSL QDPRAAIHIA ATLGNLVYLQ LLLWYNGDPT VTDHEGRNAF YYAHCSKNYD
     CADFLLRNSC PKQLVPPIPP NNMPPTIRSS QNIMPQQIVQ SHSIIHGPST STGLSSGVAD
     INISNSINSG LVQPHHFSHL QQHQSSAAVV ASEVGTHLSG QLPSYHPMTT GSVTANQQLS
     QGSNHPLVSA SGNMYTGNVN QALGATLPRR RAPIGPFPPG AVPPTLQPFP RPNIQQQVSV
     SNTHRPTSSV IQSVTRSITP NAMLRTSLVS SSQPPHTRSA SNTAATLSQP YVSTTQEVGL
//
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