ID A0A095AL73_SCHHA Unreviewed; 765 AA.
AC A0A095AL73;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=DNA polymerase eta {ECO:0000313|EMBL:KGB34846.1};
GN ORFNames=MS3_00009913 {ECO:0000313|EMBL:KAH9595198.1}, MS3_03077
GN {ECO:0000313|EMBL:KGB34846.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB34846.1};
RN [1] {ECO:0000313|EMBL:KGB34846.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAH9595198.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9595198.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9595198.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMPZ03000001; KAH9595198.1; -; Genomic_DNA.
DR EMBL; KL250638; KGB34846.1; -; Genomic_DNA.
DR RefSeq; XP_012794616.1; XM_012939162.1.
DR AlphaFoldDB; A0A095AL73; -.
DR STRING; 6185.A0A095AL73; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR GO; GO:0006301; P:postreplication repair; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR041298; UBZ3.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45873; DNA POLYMERASE ETA; 1.
DR PANTHER; PTHR45873:SF1; DNA POLYMERASE ETA; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF18439; zf_UBZ; 1.
DR PIRSF; PIRSF036603; DPol_eta; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
DR PROSITE; PS51907; ZF_UBZ3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 5..253
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT DOMAIN 653..687
FT /note="UBZ3-type"
FT /evidence="ECO:0000259|PROSITE:PS51907"
FT REGION 494..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 85412 MW; E15E1E2F734BE691 CRC64;
MNRVVMLLDM DCFYVQVEQR EFPETKGKPC VVSQYSEWKG GGALAISYEA RALGIKRGMF
SDEIRVQHPE VIIFKVPEKR GKAELTRYRD ASSEVIQCIS EFTSDIERAS IDEAYVDLTG
IVDSVLVQDD NLSSLQPNPE SYVLVSSDIA EESKLELTKT NCVSLNGVDW IQLLDSNFAE
GRRLAVASEL VYRIRQAVFT KTGFRCSAGI GPNKSIAKLA CSLNKPNKQT IIPHESIPIL
LENTHISKIR NLGGKLGSAV VKQLKIETLG QLSSIPLSVL TKEFGEKTSK WLHDLSHGID
HEVVTTRSLP KSVGCSKNFL GRATLTSSEQ IKRWLLCLAE EIFERLDVDY HQHQRYPTRL
ILYARTTNDP GYIGGISRTL PSNLLQFIGY GNRSIMNNDD GNCSNTSDLD NKLLKYTSQI
EKLANTALVI LKEVLFKGEA PEIWDPGINS LGLSAGKFLS NSSTSNADIR SLLQKKQIES
IKYDTVVQQE SMVSIPPEKS TSPSLVKLSS DNDVKNDTVN ISPDRKRNSN DSTVNINTNN
LSFFKRLRVA EISAPFHPTP LIDNLNISNN TTTNDNNTSE NKNFLLVENQ SGKLISNPIT
PPPSTTTNVQ LHQSLEQNKS STLDDSPYLE VDSESRHSTS TTSDSSNFFK SYSIGDWIIC
DKCNSRISIW QLPEHEDFHI AQRIQHEWSN KEVNINTSLT NTIITKSNDT TNSNQVNNSL
INKISSNQKS TKIKSNLKQS KSITKHQKSI KSNSGSLDQY FHKIP
//
