ID A0A095AP58_SCHHA Unreviewed; 527 AA.
AC A0A095AP58;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=E3 ubiquitin-protein ligase RNF10 {ECO:0000256|ARBA:ARBA00035131};
DE AltName: Full=RING finger protein 10 {ECO:0000256|ARBA:ARBA00035390};
GN ORFNames=MS3_00007932 {ECO:0000313|EMBL:KAH9583574.1}, MS3_0018153
GN {ECO:0000313|EMBL:KAF1338643.1}, MS3_04353
GN {ECO:0000313|EMBL:KGB36071.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB36071.1};
RN [1] {ECO:0000313|EMBL:KGB36071.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1338643.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9583574.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9583574.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- SIMILARITY: Belongs to the RNF10 family.
CC {ECO:0000256|ARBA:ARBA00008117}.
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DR EMBL; AMPZ02000069; KAF1338643.1; -; Genomic_DNA.
DR EMBL; AMPZ03000005; KAH9583574.1; -; Genomic_DNA.
DR EMBL; KL250742; KGB36071.1; -; Genomic_DNA.
DR RefSeq; XP_012795836.1; XM_012940382.1.
DR AlphaFoldDB; A0A095AP58; -.
DR STRING; 6185.A0A095AP58; -.
DR EnsemblMetazoa; XM_012940382.1; XP_012795836.1; MS3_0018153.
DR GeneID; 24591899; -.
DR KEGG; shx:MS3_00007932; -.
DR CTD; 24591899; -.
DR OrthoDB; 125113at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039739; MAG2/RNF10.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12983; RING FINGER 10 FAMILY MEMBER; 1.
DR PANTHER; PTHR12983:SF9; RING FINGER PROTEIN 10; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 132..174
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 59126 MW; B69EDDA8F4786B34 CRC64;
MEKSLVRFPM NAQRPSKSER RDGRMYTNLP VSLSSRKSYT NSSQARNRQS KQSSKRHVDL
VTSYKTKPNC AHIRCPEGEK SLEAHLDGYV QVSSQFVLIP DSAYLETNYD GTPPQWEQVS
FVKVLSKGDL VCPICLYSPI TPRMGKCGHV YCWPCALQYL KYENESDSKK CSVCPSLLSF
DGLRRVSLTH ITPTKVGDSI CLTLVKRSGL CVTPLSSLQT SEATIGSLFG CVYVTDQITL
KNIHESEIDQ LRTYRAICEV DGNNTELIPF INFAFEELNR EEMLLKSCST SSSKPCKSCS
QDINGVSTNE TYFYQAMDSQ PIFLDSLGWR CLLTEYKETQ NLPKKIVATV VSTKNYRMNS
SLRKPLRYLS HLPDGYAFSI VEIKLEPPLV SELTLSHFAT SLNNRALERD RSRLEDLKLT
ELKKAAENQF TSLPPGFVLS GHATLSAKQE VQLDPSNFVP LSATTQNIKW KETLPISFAE
ISRSGALNVV GPDRVAHFSR SPPNTTNPKR FDINSESWPT LGETSKS
//
