ID   A0A095C095_CRYGR        Unreviewed;       922 AA.
AC   A0A095C095;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Membrane protein {ECO:0000313|EMBL:KGB74425.1};
GN   ORFNames=CNBG_0263 {ECO:0000313|EMBL:KGB74425.1};
OS   Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS   (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB74425.1, ECO:0000313|Proteomes:UP000029445};
RN   [1] {ECO:0000313|EMBL:KGB74425.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB74425.1};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2] {ECO:0000313|EMBL:KGB74425.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB74425.1};
RX   PubMed=29507212;
RA   Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA   Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT   "RNAi is a critical determinant of centromere evolution in closely related
RT   fungi.";
RL   Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
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DR   EMBL; CP025762; KGB74425.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A095C095; -.
DR   STRING; 294750.A0A095C095; -.
DR   VEuPathDB; FungiDB:CNBG_0263; -.
DR   HOGENOM; CLU_005688_2_0_1; -.
DR   OMA; LWNVIGT; -.
DR   Proteomes; UP000029445; Chromosome 4.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
FT   DOMAIN          274..351
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          462..673
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          836..920
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
SQ   SEQUENCE   922 AA;  101025 MW;  C483F79C86B346E4 CRC64;
     MGAEDPEHPT NSPATAIVHI PSKGGLTQLP LPNTTCPHNN ARSGTSFAIR VTIATLILLW
     TLFNINVLTS PFKQTHPIGS VDDPSAAGYL RGVSTKGMKW ALPGPNHQLQ GTYHDGEGTE
     IREKGIKSSL IPPKSAEKIF LDIPSNDSVA AALKRYTGYA HPAGSGYDYA SALTLKNDWE
     KELGLRVSGP LEFIYDAGSP ESQARVRNGM DKLGVWIDTY YPVMNTPVYA AATLLTDPPF
     HAKLREDIVD GDSDSELRDE VPVFHGLSVS GDVKGNFVYV GYGRKQDFDL LKQRGVDIND
     KIVLAKYGGC FRGLKVKAAQ EAGAIGIIIF TDPGDDGEIT EENGYEVYPN GPARQPSSVQ
     RGSVQFISKY PGDPSTPGEP AYKNASRLEG GNQPSIPSIP MAYEDIIPFL KALEGKGIHA
     SDLGPDWVGG LGHHGVDYYV GPSDVDLHLV NEVNTRIMPI WNTMAVIPGH ITDEVIILGN
     HRDAWVLGGS DPNSGTASQF EVIRGLGTLL RKGWKPLRTI ILASWDAEEY GLIGSTEWAE
     DFGDWLQTNT AVYLNMDSSA SGSNFHASAS PSLALLVKSA AEEVESSSSP SKTVFDTRFE
     AGNWEQFNMK KLGNHVGMGD SLSEKKGSGI GALGSGSDYT PFLQRYGIAS SDLGYKSGPK
     DAVYHYHSIY DSFTWQKKFG DVEFHRHTDA AKVIGLILLR LADGLILPLN TTQYTRDLEY
     YLEKVQNISK IDLETSEIDF EPLADAIKAA QTASGKLDKR RHKALKKLHK LMRKLEHGKS
     GIVKTMLRGC GWTAGGKEVE YNLQTWEEGP KEGIFPFPHP KLPFPFPTPR KYREINSILK
     EIRIINKKLQ NFECGFLSED GLKDREWYKH KGTAPGLWLG YGATTFPALT EAITIDHSSK
     LAQKEVDELA KMINRIAKHL AA
//