ID A0A095C853_SCHHA Unreviewed; 128 AA.
AC A0A095C853;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Ubiquitin-ribosomal protein eL40 fusion protein {ECO:0000256|ARBA:ARBA00035298};
DE Flags: Fragment;
GN Name=RPL40 {ECO:0000313|EMBL:KAH9585955.1};
GN ORFNames=MS3_00007038 {ECO:0000313|EMBL:KAH9585955.1}, MS3_0014431
GN {ECO:0000313|EMBL:KAF1335057.1}, MS3_06732
GN {ECO:0000313|EMBL:KGB38353.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB38353.1};
RN [1] {ECO:0000313|EMBL:KGB38353.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1335057.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9585955.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9585955.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC -!- FUNCTION: Exists either covalently attached to another protein, or free
CC (unanchored). When covalently bound, it is conjugated to target
CC proteins via an isopeptide bond either as a monomer (monoubiquitin), a
CC polymer linked via different Lys residues of the ubiquitin
CC (polyubiquitin chains) or a linear polymer linked via the initiator Met
CC of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains,
CC when attached to a target protein, have different functions depending
CC on the Lys residue of the ubiquitin that is linked: Lys-48-linked is
CC involved in protein degradation via the proteasome. Linear polymer
CC chains formed via attachment by the initiator Met lead to cell
CC signaling. Ubiquitin is usually conjugated to Lys residues of target
CC proteins, however, in rare cases, conjugation to Cys or Ser residues
CC has been observed. When polyubiquitin is free (unanchored-
CC polyubiquitin), it also has distinct roles, such as in activation of
CC protein kinases, and in signaling. {ECO:0000256|ARBA:ARBA00029384}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the eukaryotic
CC ribosomal protein eL40 family. {ECO:0000256|ARBA:ARBA00010570}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the ubiquitin family.
CC {ECO:0000256|ARBA:ARBA00008373}.
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DR EMBL; AMPZ02000225; KAF1335057.1; -; Genomic_DNA.
DR EMBL; AMPZ03000004; KAH9585955.1; -; Genomic_DNA.
DR EMBL; KL251009; KGB38353.1; -; Genomic_DNA.
DR RefSeq; XP_012798114.1; XM_012942660.1.
DR AlphaFoldDB; A0A095C853; -.
DR SMR; A0A095C853; -.
DR STRING; 6185.A0A095C853; -.
DR EnsemblMetazoa; XM_012942660.2; XP_012798114.1; MS3_0014431.
DR GeneID; 24594096; -.
DR KEGG; shx:MS3_00007038; -.
DR CTD; 33629; -.
DR OrthoDB; 312211at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0015934; C:large ribosomal subunit; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01803; Ubl_ubiquitin; 1.
DR Gene3D; 4.10.1060.50; -; 1.
DR InterPro; IPR001975; Ribosomal_eL40_dom.
DR InterPro; IPR038587; Ribosomal_eL40_sf.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR InterPro; IPR019956; Ubiquitin_dom.
DR PANTHER; PTHR10666:SF515; POLYUBIQUITIN-B; 1.
DR PANTHER; PTHR10666; UBIQUITIN; 1.
DR Pfam; PF01020; Ribosomal_L40e; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR PRINTS; PR00348; UBIQUITIN.
DR SMART; SM01377; Ribosomal_L40e; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000313|EMBL:KGB38353.1}.
FT DOMAIN 1..76
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT NON_TER 128
FT /evidence="ECO:0000313|EMBL:KGB38353.1"
SQ SEQUENCE 128 AA; 14615 MW; 883B8F76917C08F2 CRC64;
MQIFVKTLTG KTITLEVEPA DTIEAVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
IQKESTLHLV LRLRGGIIEP TLKALAQKYN CEKMICRKCY ARLHPKATNC RKRKCGHTSN
VRPKKKLR
//
