ID A0A095CEU2_CRYGR Unreviewed; 606 AA.
AC A0A095CEU2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Translation initiation factor 2D {ECO:0000313|EMBL:KGB78767.1};
GN ORFNames=CNBG_4605 {ECO:0000313|EMBL:KGB78767.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB78767.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB78767.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78767.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB78767.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB78767.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
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DR EMBL; CP025760; KGB78767.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095CEU2; -.
DR STRING; 294750.A0A095CEU2; -.
DR VEuPathDB; FungiDB:CNBG_4605; -.
DR HOGENOM; CLU_012487_1_1_1; -.
DR OMA; DILCIID; -.
DR Proteomes; UP000029445; Chromosome 2.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IEA:InterPro.
DR CDD; cd11608; eIF2D_C; 1.
DR Gene3D; 3.10.400.20; -; 1.
DR Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR InterPro; IPR039757; EIF2D.
DR InterPro; IPR039759; eIF2D_SUI1.
DR InterPro; IPR041366; Pre-PUA.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR PANTHER; PTHR12217; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR PANTHER; PTHR12217:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 2D; 1.
DR Pfam; PF17832; Pre-PUA; 1.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; eIF1-like; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS50296; SUI1; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
PE 4: Predicted;
KW Initiation factor {ECO:0000313|EMBL:KGB78767.1};
KW Protein biosynthesis {ECO:0000313|EMBL:KGB78767.1}.
FT DOMAIN 412..498
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT DOMAIN 514..590
FT /note="SUI1"
FT /evidence="ECO:0000259|PROSITE:PS50296"
FT REGION 221..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 65934 MW; B1AF13B57EA25D68 CRC64;
MFKKPPAHQS NATPIRSSAR RQLLSAILEQ YPSLLAQGET DDDSKKELGK LILPEGVRVA
TFETSTGLEG TFWLSPNGDP LWMTLGRNSK EYIPTLSLLS LPLPRPPLPV IQIYHPLPPP
ILTGAPLFIP AVRNIDKPHR LPAVNKNQLV AFVTSPTKDD SVHYIGVGRV AAEGGMKGAW
ERRVNNLMDG GDREEGKFSD ILCIVDDHLW DLGSKPTLST FTLPPPQNPL AAPPEGFEQT
PKSPSPPAIQ QLSISAEDGS EASIPVSTSL SASEISSLLS LSLLQALSGL QPSAFPMSAS
LLYSSHILPS RPAYIPKAER DEVVVGKSDW KKLAKWMKEA SKEGIMKIKE NKGEVTVVSF
DSRHPSLQAH VDYMTIAQEE AKASKKAARE AASEQTTNGG KSSNKQSLDI EELWKPAGGA
ISFWEACGIS KSDYHSPPTL KQALDGYITS HNLPDPTNYK FILLDDELGR AVGIKKPEAS
AKMARDEILN KLKNGVSWVV SIGGTIKKGA LQPITMTVKS RGGRRTVTHV TGLELFNVDI
ESFAEDMRKR CAGSASIQPR EGVSPKLGLQ EVLVQGSQQK LITEALLERG VPKRWIKDEG
DKKGKK
//
