ID A0A095CJD8_CRYGR Unreviewed; 846 AA.
AC A0A095CJD8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dethiobiotin synthase {ECO:0000313|EMBL:KGB80282.1};
GN ORFNames=CNBG_6120 {ECO:0000313|EMBL:KGB80282.1};
OS Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB80282.1, ECO:0000313|Proteomes:UP000029445};
RN [1] {ECO:0000313|EMBL:KGB80282.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB80282.1};
RX PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA Birren B.W., Galagan J.E., Cuomo C.A.;
RT "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT immunocompetent hosts.";
RL MBio 2:E342-E342(2011).
RN [2] {ECO:0000313|EMBL:KGB80282.1, ECO:0000313|Proteomes:UP000029445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R265 {ECO:0000313|EMBL:KGB80282.1};
RX PubMed=29507212;
RA Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT "RNAi is a critical determinant of centromere evolution in closely related
RT fungi.";
RL Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004746}.
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DR EMBL; CP025762; KGB80282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A095CJD8; -.
DR STRING; 294750.A0A095CJD8; -.
DR VEuPathDB; FungiDB:CNBG_6120; -.
DR HOGENOM; CLU_010794_0_0_1; -.
DR OMA; KGWASRA; -.
DR Proteomes; UP000029445; Chromosome 4.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR CDD; cd03109; DTBS; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR42684; ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42684:SF21; ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; 1.
DR Pfam; PF13500; AAA_26; 1.
DR Pfam; PF00202; Aminotran_3; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE 4: Predicted;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 846 AA; 93161 MW; 6C0A796F55A5CB9B CRC64;
MPLLFPNFRV HQVFGANTEV GKTLLTTALL RASASRYVSK SEVARKRVFY LKPVSTGPDS
ESDTSYVQRN TKPYSSYIST HNLYQYREPM SPHLAAQLAP DLPFPKTNEE LVRGIEAHAN
KCLQQLDGQD GCLFVETAGG VHSPALHLPH TQSTFLRSLR LPSVLVASPH LGGISTTVSA
YESLLLRGYS LSAVLCLHDS YYRNHTFLEE YFRDRGIGYW TIKPPPEKYG TVEEDGVRLE
QWYKEVEKSF EGEQGGGVGA AARWLEKGHK RRIEELGEMP QRTLDSVWWP FTQHQLIDKK
EDVMVVDSAF GDNFDSYYAK PESAPSSKNE SLLKSYFDGS ASWFTQSHGH ANEQLTLAAA
SAAGRYGHVL FPSGTNAPAL SLAEKLISTV GEGWASRVFY SDNGSTAMEV GLKMALRAAG
RRYGWDGEMG GDVGVIGLRG SYHGDTIGSM DATQASTYNK AVDWYKGRGH WFSPPMVQFV
NGAPTVLTTG PDSWSPLPSS IASSSKSTRD GWAFEFASFK DVYDISSRSS SPLATYYRAH
IRSTLERLVK EGKKFGALVM EPTCLGAGGM VFVDPLFQSC MIEVVRASGD LFAGEKWDGG
SFKQELEGLK TRSGAEWQGL PVLYDEVFSG LHRFGYNSAA TVLGHTPDIS AYAKILTGGL
LPMSTTLASP SIFSAFLSPR KVDALLHGHS YTANPIGCAV ALEAMKLTTD YEAKGGWQGE
KNMWEVEKGT EGRWSFWKKE FVEDISRVEG VKGSMAMGTV FAIELQDDES DYSSHAALDF
LTTLRQVVVT PSSHAAAEDI VPFSPFQIHS RPLGNVVYII TSLWTKPDVM RAMEKVILDK
LTKKAQ
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