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Database: UniProt
Entry: A0A095DA72_CRYGR
LinkDB: A0A095DA72_CRYGR
Original site: A0A095DA72_CRYGR 
ID   A0A095DA72_CRYGR        Unreviewed;       263 AA.
AC   A0A095DA72;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=deoxyribose-phosphate aldolase {ECO:0000256|ARBA:ARBA00012515};
DE            EC=4.1.2.4 {ECO:0000256|ARBA:ARBA00012515};
DE   AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase {ECO:0000256|ARBA:ARBA00032755};
GN   ORFNames=CNBG_3719 {ECO:0000313|EMBL:KGB77881.1};
OS   Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS   (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB77881.1, ECO:0000313|Proteomes:UP000029445};
RN   [1] {ECO:0000313|EMBL:KGB77881.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB77881.1};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2] {ECO:0000313|EMBL:KGB77881.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB77881.1};
RX   PubMed=29507212;
RA   Yadav V., Sun S., Billmyre R.B., Thimmappa B.C., Shea T., Lintner R.,
RA   Bakkeren G., Cuomo C.A., Heitman J., Sanyal K.;
RT   "RNAi is a critical determinant of centromere evolution in closely related
RT   fungi.";
RL   Proc. Natl. Acad. Sci. 115:3108-3113(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde
CC         3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000764};
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. DeoC type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010936}.
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DR   EMBL; CP025759; KGB77881.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A095DA72; -.
DR   STRING; 294750.A0A095DA72; -.
DR   VEuPathDB; FungiDB:CNBG_3719; -.
DR   HOGENOM; CLU_053595_0_2_1; -.
DR   OMA; MAGGIRT; -.
DR   UniPathway; UPA00002; UER00468.
DR   Proteomes; UP000029445; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004139; F:deoxyribose-phosphate aldolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009264; P:deoxyribonucleotide catabolic process; IEA:InterPro.
DR   GO; GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00959; DeoC; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00114; DeoC_type1; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011343; DeoC.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR028581; DeoC_typeI.
DR   NCBIfam; TIGR00126; deoC; 1.
DR   PANTHER; PTHR10889:SF1; 2-DEOXY-D-RIBOSE 5-PHOSPHATE ALDOLASE; 1.
DR   PANTHER; PTHR10889; DEOXYRIBOSE-PHOSPHATE ALDOLASE; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF001357; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Schiff base {ECO:0000256|PIRSR:PIRSR001357-50}.
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with acetaldehyde"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001357-50"
FT   ACT_SITE        204
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001357-50"
SQ   SEQUENCE   263 AA;  28084 MW;  149D4DB5A77EA03C CRC64;
     MSSSTNTIEV TLTQIAKMID HSLLHPTMTD ADILEGLKIA KQYNVATACV KPYLIPLAKK
     ELAGTDVLVC PVIGFPAGNS TTEVKVFEAD RAAAEGGKEI DMVINIGKAL GGDWDYVSSE
     IKQINDAVVK HGAILKVIFE NDYLKDNHIV KLCEICSDIG VGFVKTSTGY GFVKQPNGLY
     TYAGATIPQL KLMRKHSKPE VQVKAAGGVR TLDDLLHVMS LGVTRIGATA TIAIMEAAKA
     RGITDKPTTV EFTPMADVAS GGY
//
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