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Database: UniProt
Entry: A0A095EBC5_CRYGR
LinkDB: A0A095EBC5_CRYGR
Original site: A0A095EBC5_CRYGR 
ID   A0A095EBC5_CRYGR        Unreviewed;       849 AA.
AC   A0A095EBC5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   07-JUN-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CNBG_0676 {ECO:0000313|EMBL:KGB74838.1};
OS   Cryptococcus gattii serotype B (strain R265) (Filobasidiella gattii)
OS   (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=294750 {ECO:0000313|EMBL:KGB74838.1, ECO:0000313|Proteomes:UP000029445};
RN   [1] {ECO:0000313|EMBL:KGB74838.1, ECO:0000313|Proteomes:UP000029445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R265 {ECO:0000313|EMBL:KGB74838.1,
RC   ECO:0000313|Proteomes:UP000029445};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T.,
RA   Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q.,
RA   Bartlett K., Li W., Wang X., Heitman J., Stajich J.E., Fraser J.A.,
RA   Meyer W., Carter D., Schein J., Krzywinski M., Kwon-Chung K.J.,
RA   Varma A., Wang J., Brunham R., Fyfe M., Ouellette B.F., Siddiqui A.,
RA   Marra M., Jones S., Holt R., Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KQ410558; KGB74838.1; -; Genomic_DNA.
DR   EnsemblFungi; KGB74838; KGB74838; CNBG_0676.
DR   OMA; WTAYDAH; -.
DR   Proteomes; UP000029445; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029445};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029445};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    419    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    473    490       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    565       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    586    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    662       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    787    809       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       98    139       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   849 AA;  95959 MW;  42C21F3EE23485CA CRC64;
     MATNYPSLFR SEEMSLVQLY IPSEVAHDTI SELAEMSNFQ FKDLNPSLTS FQRSFTPRLR
     RLAEMARRLR LFRSQITSLS PPLGIPPLAS VPPFTTVGPR AQNAYDELEE KLKEHERRLN
     EMNKSWEELG RRKSELEENK CVLKETAGFF DEAGHRHTEI RTSMEDSSDA APLLEHAAEY
     GTLPGETGLS GFDLEFVAGT IDRTRMPTFE RILWRVLRGN LYMNYSEIEE PFVDTVSGKE
     TFKDVFIIFA HGQELLAKIR KVAESMGGTL YNIDSSTDKR ADALRQVSAR LEDVDNVLYN
     MGQTRRVELS KIAESLEAWT DAVKREEEIY KTLNLLSYDQ GRKTLVAEGW CPSRDITAIQ
     LGLRRAMDTA GTSVPAILSE LRTHQTPPTF HRTNKFTEGF QTLIDSYGIA TYQEVNPGLY
     AVITFPFLFA VMFGDIGHGI LMFLTAAAMI FWEKQIAKNG VNENVETFFF GRYLIVLMGA
     FSVFTGFMYN DIFSKTLHLW QSGWEWPSNS TGLVEAESTG HIYPFGMDPM WHGSDNALIF
     NNSYKMKMSI ILGVIHMTFA ICLQVPNHIH FKKPLNIYAE FIPQMLFFHS IFGYLVICII
     YKWSVDWSQS ATSPPGLLNM LIYMFLSPGT IEPGTQLYAG QGFIQVILLL IALVCVPWML
     ALKPYMLWKE HQRIVAQGYQ GLQGQDNGGM NGRNSIGAES RAEEEEEVGM AVAESSDEEH
     PFEMADIIVH QVIHTIEFCL GCISNTASYL RLWALSLAHA QLSEVLWSMT LQLAFDFNGG
     LVSRAVFLFI MFAVWFGGTI GILCVMEGLS AFLHALRLHW VEANGKHYMA GGYPFTPLSF
     ATIGQEEDV
//
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