ID A0A095VSM6_9GAMM Unreviewed; 654 AA.
AC A0A095VSM6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Methylcrotonyl-CoA carboxylase biotin-containing subunit {ECO:0000313|EMBL:KGE04375.1};
DE EC=6.4.1.4 {ECO:0000313|EMBL:KGE04375.1};
GN ORFNames=HRUBRA_01061 {ECO:0000313|EMBL:KGE04375.1};
OS Pseudohaliea rubra DSM 19751.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Pseudohaliea.
OX NCBI_TaxID=1265313 {ECO:0000313|EMBL:KGE04375.1, ECO:0000313|Proteomes:UP000029640};
RN [1] {ECO:0000313|EMBL:KGE04375.1, ECO:0000313|Proteomes:UP000029640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19751 {ECO:0000313|EMBL:KGE04375.1,
RC ECO:0000313|Proteomes:UP000029640};
RX PubMed=25414506;
RA Spring S., Fiebig A., Riedel T., Goker M., Klenk H.P.;
RT "Genome Sequence of Gammaproteobacterial Pseudohaliea rubra Type Strain DSM
RT 19751, Isolated from Coastal Seawater of the Mediterranean Sea.";
RL Genome Announc. 2:e01208-14(2014).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGE04375.1}.
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DR EMBL; AUVB01000028; KGE04375.1; -; Genomic_DNA.
DR RefSeq; WP_035515020.1; NZ_KN234752.1.
DR AlphaFoldDB; A0A095VSM6; -.
DR STRING; 1265313.HRUBRA_01061; -.
DR PATRIC; fig|1265313.6.peg.1046; -.
DR eggNOG; COG4770; Bacteria.
DR HOGENOM; CLU_000395_3_1_6; -.
DR OrthoDB; 9763189at2; -.
DR Proteomes; UP000029640; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004485; F:methylcrotonoyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866:SF126; BIOTIN CARBOXYLASE; 1.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KGE04375.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000029640}.
FT DOMAIN 5..451
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 124..322
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 571..651
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 654 AA; 70274 MW; 9F1225BA5C37C8C6 CRC64;
MNERRLRRVL IANRGEVALR VAEACRRRGI ETVAVYSDAD ANSPHRLAAE QAFRLPGSEA
TETYLAIDRL LAVAARAGAD AVHPGYGFLA ESAAFARAVR AAGLVFIGPA PDVIETMADK
QRARALVDGL GLPVIPGENP ATQADDCLRE AAGRVGFPLL IKAVAGGGGM GMRVVPQPDA
FAAGLAAVRR EAAAAFGDDR VLLERFVAGV HHVEVQLLAD RYGTVAHAFD RECSVQRRRQ
KVIEEAPSPN LSPALRSRLC EAAVKIASAV DYCGLGTVEF IVQPGNETFY FLEMNTRLQV
EHAVTEQVTG LDLVDWQLRL AEGEAIGSAL DDLVLRGHAV EARLYAEDPA HGFLPAAGKL
ARWVPVVPPG GQLMSSVIQG MELSSRYDPM LAKFIVAAPT RAEACRLLRW SLGRSIALGL
PTNRELLCAV LDDEDYLAGR ATTAFLDERP ELACRPSAEA WRAALPPLAF WQWSRERARH
RALGRTKAVY RYQQSDAVQS AEVHVADRGE GSARMELDGR SLDVSLLHIA DDGALHIDLD
GHARPWHFCS IAGEHYFCAA NGPVMVARES SAGLDLTPNN EPGTYLAPMP GRIIAVAARG
GSVMNEGDCL CVLESMKMEH AVCARESARV TGVAVSVGDS VSKGQLLVTM ESAN
//
