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Database: UniProt
Entry: A0A095X7N8_9ACTO
LinkDB: A0A095X7N8_9ACTO
Original site: A0A095X7N8_9ACTO 
ID   A0A095X7N8_9ACTO        Unreviewed;       532 AA.
AC   A0A095X7N8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1631_05560 {ECO:0000313|EMBL:KGF05696.1};
OS   Arcanobacterium sp. S3PF19.
OC   Bacteria; Actinobacteria; Actinomycetales; Actinomycetaceae;
OC   Arcanobacterium.
OX   NCBI_TaxID=1219585 {ECO:0000313|EMBL:KGF05696.1, ECO:0000313|Proteomes:UP000054502};
RN   [1] {ECO:0000313|EMBL:KGF05696.1, ECO:0000313|Proteomes:UP000054502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S3PF19 {ECO:0000313|EMBL:KGF05696.1,
RC   ECO:0000313|Proteomes:UP000054502};
RA   McCorrison J., Sanka R., Torralba M., Gillis M., Haft D.H., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGF05696.1}.
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DR   EMBL; JRMX01000014; KGF05696.1; -; Genomic_DNA.
DR   RefSeq; WP_034233114.1; NZ_JRMX01000014.1.
DR   EnsemblBacteria; KGF05696; KGF05696; HMPREF1631_05560.
DR   Proteomes; UP000054502; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054502};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054502}.
FT   DOMAIN      218    354       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      430    499       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     226    233       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   532 AA;  59393 MW;  0BBF79B2C9DD1286 CRC64;
     MTENFAARDA WLAATELLRA EGKLSDSQLA FMRLAKPLAT VDEVFMLGVG SDFVKDWINE
     HINPIMTAQL SAILGRQIKL MISVDPALSE QAVQSPQTSL PPAFPAAAPS PLPPTANEFG
     IESALAERSF PNFSNPPAPA SAPQPFRQDE EDEPEFFFTS AEERLPDRES APHPSDISAL
     QAQAHLNPRY TFDTFVIGES NRFAHATAFA VSEAPGSSYN PLFFYSEPGM GKTHLLHAIG
     NYTLGLYPKM KVLYISAEEF ANIFINAVMS KDMRPFKEKF RNVDVLLIDD IQFISKKEKS
     SEEFFHTFNA LSSANKQIVV TSDVPPKHLN GFDERMISRF ASGITASIDL PNFETRIAIL
     ERKAITEHLQ IPRPVLEFIA SKMTTNVREM EGCLRRIAAY ADLSQKELTL DMAELVLKDI
     LSDPNSIKIT AGIIIAQTAS YFDISVEELK SPARTRNLTV PRHISMYLCR EMTDYSLPKI
     AELFNRRDHT TVINALRKVE KQMAEKQSLF NQVSELTGRI RQAAKEANNL SA
//
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