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Database: UniProt
Entry: A0A095YSY3_9FIRM
LinkDB: A0A095YSY3_9FIRM
Original site: A0A095YSY3_9FIRM 
ID   A0A095YSY3_9FIRM        Unreviewed;       458 AA.
AC   A0A095YSY3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1635_01765 {ECO:0000313|EMBL:KGF09647.1};
OS   Clostridiales bacterium S5-A14a.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Clostridiales Family XIII. Incertae Sedis.
OX   NCBI_TaxID=1230734 {ECO:0000313|EMBL:KGF09647.1, ECO:0000313|Proteomes:UP000029601};
RN   [1] {ECO:0000313|EMBL:KGF09647.1, ECO:0000313|Proteomes:UP000029601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S5-A14a {ECO:0000313|EMBL:KGF09647.1,
RC   ECO:0000313|Proteomes:UP000029601};
RA   McCorrison J., Sanka R., Torralba M., Gillis M., Haft D.H., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGF09647.1}.
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DR   EMBL; JRNA01000008; KGF09647.1; -; Genomic_DNA.
DR   RefSeq; WP_034432904.1; NZ_JRNA01000008.1.
DR   EnsemblBacteria; KGF09647; KGF09647; HMPREF1635_01765.
DR   Proteomes; UP000029601; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029601};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029601}.
FT   DOMAIN      151    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      365    434       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     159    166       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   458 AA;  53000 MW;  8983AAC234AE7505 CRC64;
     MISEPNSVWI RVKDNLRELI PSPSYETFIK PVTLNCIDED IFIFYLEVPD NIDLDIVNRY
     KIRLESIIQK QTGTAYKVIT KHKSEYGNNS NQHLKRSSNV GNFDVLKIEP DSKAYDEYFI
     PSYTFDNFVE GSCNKVACAA AHAVAENPSQ AYNPLYIYGK SGLGKTHLIN AIGLYIQETR
     PELNVIYVTS ETFTNECTHA IKQNKMNEFK RKYRKADVLL IDDIQFLENK DTTQEEFFHT
     FNELYKYEKQ IIISSDRPPQ RLTRLDERLR SRFAWKMMAD IQPADYETRI AILMKKAESK
     GIEITDDVYD VIKLVAESIT DNIRNLEGAF NRIISFSVLL NRNIDVTFAN DILKDIVTSK
     SVLPTPEKIK QIVCNHFDIG LDEMEGAKRT NRIAYPRQIA MYISREITDY SLPKIGRCFG
     GRHYSTVIHA HEKIQKKIKD DETLKGIVDL LIEKSKER
//
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