ID   A0A096B401_9BACT        Unreviewed;       493 AA.
AC   A0A096B401;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Nucleotide pyrophosphatase {ECO:0000313|EMBL:KGF37532.1};
GN   ORFNames=HMPREF2137_00010 {ECO:0000313|EMBL:KGF37532.1};
OS   Hoylesella buccalis DNF00853.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Hoylesella.
OX   NCBI_TaxID=1401074 {ECO:0000313|EMBL:KGF37532.1, ECO:0000313|Proteomes:UP000029556};
RN   [1] {ECO:0000313|EMBL:KGF37532.1, ECO:0000313|Proteomes:UP000029556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00853 {ECO:0000313|EMBL:KGF37532.1,
RC   ECO:0000313|Proteomes:UP000029556};
RA   McCorrison J., Sanka R., Torralba M., Gillis M., Haft D.H., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGF37532.1}.
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DR   EMBL; JRNN01000001; KGF37532.1; -; Genomic_DNA.
DR   RefSeq; WP_036871089.1; NZ_JRNN01000001.1.
DR   AlphaFoldDB; A0A096B401; -.
DR   OrthoDB; 9766127at2; -.
DR   Proteomes; UP000029556; Unassembled WGS sequence.
DR   GO; GO:0004035; F:alkaline phosphatase activity; IEA:InterPro.
DR   CDD; cd16016; AP-SPAP; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR026263; Alkaline_phosphatase_prok.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR10151:SF126; PHOSPHODIESTERASE; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   PIRSF; PIRSF031924; Pi-irrepressible_AP; 2.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|PIRSR:PIRSR031924-50};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..493
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001916909"
FT   ACT_SITE        75
FT                   /note="Phosphothreonine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR031924-50"
FT   BINDING         96
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR031924-51"
FT   BINDING         155..157
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR031924-51"
SQ   SEQUENCE   493 AA;  55173 MW;  A748AFE81CA92DA7 CRC64;
     MKKFFTLCTL LVCSSLLMMA QPKKPKLVVG IIVDQMRWDY LPYYESRFGQ DGFNRLMNGG
     FSFDNLNINY TPTVTCAGHT HVYTGSVPAI SGIAGNNFYI NGQRVYCAED NTVSSVGSQS
     KAGKMSPRNL KVTTMTDALR LANDFRSRTI SISIKDRSAI MPGGHTANAA YWMDVSAGSF
     ITSTYYMNEL PAWLKAFNKK NYDIIKRDVR TDPEGNSILV RLAMEVLDNE KLGQGDETDF
     LAMSFSSTDY VGHKYGVRSK QTDAIYLNLD KELGKLLNKL DEKVGKGNYL LFLTADHGAS
     HNTDYLRAHK IQAGTWDARA TMKALNEHLS SKFGVAKPLV KDYIEYRIYL DHETIGQSNL
     DIQKVKDEIA AFLKQDTKIE FVVDYENMES LPMPARLKNM MRNGYNAQRS GDMEVVLSPA
     HYEHAGTAPH QGTTHGVWNP YDSHIPFVLY GWGIPHGRSG YEATINDIAP TICNLLKIQV
     PNGSIGKPLP FKE
//