ID A0A096LPK2_HUMAN Unreviewed; 92 AA.
AC A0A096LPK2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=N-acetylglucosaminylphosphatidylinositol deacetylase {ECO:0000256|ARBA:ARBA00012176};
DE EC=3.5.1.89 {ECO:0000256|ARBA:ARBA00012176};
DE Flags: Fragment;
GN Name=PIGL {ECO:0000313|Ensembl:ENSP00000485657.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000485657.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000485657.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000485657.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PIGL family.
CC {ECO:0000256|ARBA:ARBA00006066}.
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DR EMBL; AC005971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; A0A096LPK2; -.
DR PeptideAtlas; A0A096LPK2; -.
DR Antibodypedia; 2335; 123 antibodies from 20 providers.
DR Ensembl; ENST00000463810.2; ENSP00000485657.1; ENSG00000108474.17.
DR UCSC; uc060brn.1; human.
DR HGNC; HGNC:8966; PIGL.
DR VEuPathDB; HostDB:ENSG00000108474; -.
DR GeneTree; ENSGT00390000018434; -.
DR HOGENOM; CLU_2432550_0_0_1; -.
DR UniPathway; UPA00196; -.
DR ChiTaRS; PIGL; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000108474; Expressed in mucosa of stomach and 154 other cell types or tissues.
DR ExpressionAtlas; A0A096LPK2; baseline and differential.
DR GO; GO:0000225; F:N-acetylglucosaminylphosphatidylinositol deacetylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.10320; LmbE-like; 1.
DR InterPro; IPR003737; GlcNAc_PI_deacetylase-related.
DR InterPro; IPR024078; LmbE-like_dom_sf.
DR PANTHER; PTHR12993:SF11; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE; 1.
DR PANTHER; PTHR12993; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED; 1.
DR SUPFAM; SSF102588; LmbE-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A096LPK2,
KW ECO:0007829|PeptideAtlas:A0A096LPK2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..92
FT /note="N-acetylglucosaminylphosphatidylinositol
FT deacetylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001926980"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000485657.1"
SQ SEQUENCE 92 AA; 10414 MW; D3BEF378868A6DC7 CRC64;
XCVALAVLAW GFLWVWDSSE RMKSREQGGR LGAESRTLLV IAHPDDEAMF FAPTVLGLAR
LRHWVYLLCF SAVFRRELSE YTEGLTSEPL TA
//
