ID A0A096LQ08_POEFO Unreviewed; 1183 AA.
AC A0A096LQ08;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=G protein-coupled receptor 158a {ECO:0000313|Ensembl:ENSPFOP00000021249.1};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSPFOP00000021249.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021249.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000021249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AYCK01006307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01006308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01006309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01006310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01006311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01006312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LQ08; -.
DR Ensembl; ENSPFOT00000025406.1; ENSPFOP00000021249.1; ENSPFOG00000007298.2.
DR GeneTree; ENSGT00940000155918; -.
DR OMA; THVCLPC; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF11; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 269..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..520
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 771..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 132147 MW; 33A9FACC6B741EFA CRC64;
QANRSREHNL RRDMEWYHAL VRSILEADAK IHRAVVTFGG DASFAGPPVL LQATRAGGEI
VLQDLPRMAR RHLHNRTADT EWYHAMREKQ EPRFHKRVLS KGGDGSPERA ESFIPDRTHV
KWSAPYLECE NGNFVPRWLL TLSAAFYGLK SNLDPEFRGV VRVDVNLQDV DIDQCSTDGW
FAGTHRCNLT TMECLPLRGH GFVLDKYQCQ CKKGLYHPNR VAVNGFTKKK GEELSVTGCY
TAVGDCLPCQ QGCAFCKDNS PCVVLEDGAL RLAVLSFQCL CMLIVFISMV LIYHFRRNKS
IRASGLVLLE AILCGALLLY FPVGIIYFHP SVFRCILLRW VRLLGFATVY GTLTLKLYRV
LKVFLSRTAQ RIPYMTSWRV LRLLAIILLI VCWFLVAWTS AVCQNPDRKL ALIDVGHTPD
GSQFGMCLLD RWDYMMAVAE FLFLLWAVYL CYAVRTVPSA FHEPRYMAIA VHNELVLSAI
FHVIRFTLAH ELHPDWMLLL FFTHTHLTVT VTLGLLLVPK FLFAGTHMRD DIASEAYEDE
LDMGRSGSYL NSSITSAWSE HSLDPEDIRE ELKKLYSQLE IYKRKKMLAN NPHLQKKRSS
KKGLGRSLMR RITEIPESVH RQCSREDKEV GDYGSNRNSI CMLKKNPLDP SHQVKPAKEE
TLKNKVFSLK KSHSSYDHVR DQNEDANRAT ADKMETATNE GSLLDTLMGK KLVKKKSSEN
ISAPSESTES VPLVCKSASA HNLTADKKPI HPRASMLQKS LSVIASAKEK TLGLTGKTQS
SEDSNKKSQP KSKDTKANAE AENDCQPKMI ISQSVDYKQS AAKGRIMKQP VTGSQPAICS
DPVRGKDLYD VSEVCPWELE DLPTPSENKI QKHVSIAPTE STTIHGGSTK GSKSQKQKAS
DQSPSGGKHS KESQRTTSVR AEVCPWEEGG ETQACLSEGP RQQVSSQSRS NRPHSTLESS
KTKRADICPW DFEEQQKVTE LARSPDTMKQ KKSSSPVDGR GRNPISDAPK GVTSLPLSTT
KAEICPWDYD SAAVSPSTDR TPSPAQAPKA KESPTIRKGA PSTRTVEKEK SKDTEDEKSL
TKSSDKRLSQ QKLSEVCPWD VESPQEGPQE EKRKSANVGA AKPKQAEVCP WDFEDVSSKT
GSDKNAPVEK QSNPNLKAVA ASSAKKAEVC PWDFDESKSS KKA
//
