ID A0A096LQS0_POEFO Unreviewed; 973 AA.
AC A0A096LQS0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL1A {ECO:0000313|Ensembl:ENSPFOP00000021511.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000021511.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000021511.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; AYCK01004048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01004049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LQS0; -.
DR Ensembl; ENSPFOT00000025455.1; ENSPFOP00000021511.1; ENSPFOG00000016447.2.
DR GeneTree; ENSGT00940000155295; -.
DR OMA; AQTCQQK; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13285; PH_ORP1; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 238..338
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 463..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..824
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 108786 MW; DAF9DA6CA18E9EB7 CRC64;
MEDLEPEEQF LQCARNGDLP GVQELLRSNA AAERRININC KGQSKSNLGW TPLHLACYFG
HRDVVEELLK AGANVNLPNN IGDTALHKAA FTGRKEVVML LLHYDACAAV INGSAQIPKD
VTQNAEIRSM LEAAERTEER KLEEKLLEAA REGDLSTLTQ LLSRKKPPDI NCTDLLGNTP
LHCAAYRGQR LCALKLLRSG ADASAKNKNG QTVFDLASDA AMKQCLEGNI HRGLTRHVKK
YEGLLWKSSR FFGWRSYWVV VLDGVISWYP KQSDAAANVR RQGCKSLTNA HCLIRAKDNC
FFTLKCFDDS VHHFKVCPKS EPEATRKAWL DALEEHSAYS THYCSSLGEL TDSLQSLAHL
HLSHVSLTHQ AAEVSQKKLE QEVAAFLSML RDDGLSERFP SAALQKMQEI CDLSSKTASS
LGACLSLFSR QEGAGSVKLE QEVEKNKILS EALQTLATEH HELEQSVVKG SSPRSALSED
EFHDAVSESG SELSLSGFET VASNSFEEDE EEDEGSVMLS SPCSSPATSM LQEDHHGDRD
ETQSNGITKH RASLPAPMFS RNDFSIWSIL RNCIGMELSK ITMPVIFNEP LSFLQRLTEY
MEHTYLIHQA NSSSDPIERM KCVAAFAVSA VASQWERTGK PFNPLLGETY ELVRDDLGFR
LISEQVSHHP PVSAFHAEGL KQDFVFHGSI YPKLKFWGKS VEAEPKGIIT LELPKHNEAY
TWTNPTCCVH NIIVGQLWIE QYGNVEVVNH RTGEKCCLNF KPCGLFGKEL HKVEGYILDK
SKKKLCALYG KWTESLYVVD PAAFEAHKKS DKKGAEEKKA GKAGSSGDQE GVPSPAPDTV
EVIPGSQLLW RIAPRPANST QMYSFTSFAM QLNELHKDME GVIPQTDCRL RPDIRAMENG
DIDLASEEKK RLEEKQRAAR KNRTKSDEEW KTRSPPLGPR WFQQGPNPHT RSQDWLFSGG
YWDRSYSQLP DIY
//
