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Database: UniProt
Entry: A0A096LVC5_POEFO
LinkDB: A0A096LVC5_POEFO
Original site: A0A096LVC5_POEFO 
ID   A0A096LVC5_POEFO        Unreviewed;      1854 AA.
AC   A0A096LVC5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 18.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023116, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000023116, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000023116};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000023116}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000023116}.
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DR   EMBL; AYCK01001221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000029779; ENSPFOP00000023116; ENSPFOG00000016785.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    228    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    255    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    396    424       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    588    612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    624    645       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    665    686       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    735       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    794    820       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1026   1044       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1065   1081       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1093   1113       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1142   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1268   1291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1350   1368       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1380   1402       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1414   1433       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1477   1503       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1515   1534       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1571   1594       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    430       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      597    824       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      834   1019       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1024   1299       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1349   1603       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      427    454       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1854 AA;  210537 MW;  EA7C43561FDFA589 CRC64;
     MANLLPPPGI AVFRPFTQES LAEIKRLAEE RKKSAEAEDH DGGEPVGPHP DLEAGKSLPL
     IYGDPPPELL NTPLEDLDPF YKAQNTFVVI SKGNTIYRFN AEPACYILSP FSVIRRGSIK
     ILIHSYPFVY LASTFCMFIM ITILSNCVFM TMSNPPAWSK TVEYVFTGIY TFEATVKVLS
     RGFCIGSFTF LRDPWNWLDF MVISMAYITE FVDLGNVSAL RTFRVLRALK TITVIPGLKT
     IVGALIQSVK KMGDVMVLTV FALAVFALVG LQLFMGNLRH KCVRWPILMN EVFNATMAVN
     ESMYSNSSFD FAEYIENPEN QYFTEGSIDA LICGNSSDAG KCPEGYTCMK AGRNPNFGYT
     SYDSFGWAFL ALFRLMTQDF WENLFQLTLR AAGRTYMLFF VVVIFLGSFY LINLILAVVA
     MAYYEQNQAT QLEAIEKEEE FQRLLEQLKN QEQAQFHGSR ATLASKKSAS QHTLSEMEDN
     GPGLKQGEAV NDCNGRVVPR LMIRAPTMEE SAVDYEVKEK SLGSVHSTLH LEEPGLKKRS
     GSAATVLSVV AMEELEEAQR PCPLCWYKFA DMFLKWDCCP TWIVFKKWVH FVVMDPLVDL
     AITICIVLNT LFMAMEHYPM TPEFDNMLSV GNLVFTGIFA AEMFFKLIAM DPYYYFQVGW
     NIFDSIIVTL SLVELGLANV QGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN
     LTLVLAIIVF IFAVVGMQLF GKNYKDCVCK ISADCELPRW HMNDFFHSFL IVFRILCGEW
     IETMWDCMEV AGPAMCLIVF MMVMVIGNLV VLNLFLALLL SSFSGDNLSA GDEDGEMNNL
     QIAIGRITRG IDWLKAFLIQ RIQQILGKKP KESDKETADD GKPKAEEVKM NHLDACLTLK
     VADGISDGPV QSQPSGFTVD GELNLKVPIA EGESDYDNLS DDDDEDDANE CDDGDSSVCS
     TVDYRPPEPE PEKKEEEEPE PEEPEACFTD DCVTKWPCLT VDTTSGKGKE WWNLRKTCFT
     IVEHDWFETF IIFMILLSSG ALAFEDIYIE RRRTIKIILE FADKVFTYIF VIEMLLKWVA
     YGFKTYFTNA WCWLDFFIVD ISLISLVANW MGYSDLGPIK SLRTLRALRP LRALSRFEGM
     RVVVNALVGA IPSIFNVLLV CLIFWLIFSI MGVNLFAGKF YRCINTTTEE LFPMTEVNNR
     TECLALEEAT REARWINVKI NYDNVGKGYL SLLQVATFKG WMDIMYAAVD SREVVEEQPS
     YEINLYMYIY FVIFIIFGSF FTLNLFIGVI IDNFNQQKKK FGDQDIFMTD EQKKYYEAMK
     KLGSKKPQKP IPRPMNPVQG IVFDFISQQF FDIFIMVLIC LNMVTMMVET DDQSPEKEDF
     LFKLNVAFIV VFTGECVLKL FALRQYFFTN GWNVFDFIVV ILSIAGTMLS DIIEKYFVSP
     TLFRVIRLAR IGRILRLIKG AKGIRTLLFA LMMSLPALFN IGLLLFLIMF IFSIFAMSNF
     AYVKKEAGID DIFNFETFGG SIICLFQITT SAGWDGLLLP MLNREPPDCD PEFENPGTDV
     KGNCGNPGMG MMFFCSYIIV SFLVVVNMYI AIILENFNVA QEESGDPLCE EDFEMFNETW
     EKFDLDGTMF IEYSRLSDFC DTLQEPLRVA KPNRLRLIGM DLPLVIGDRI HCLDVLMAVT
     QMVLGDTVEM AAMRDSIEAK FILSNPTKDS FAPITTTVRH KEEQQAAVVL QRAYRNHLLK
     RCVRHAAYMH RLKRIGRNYN DDDPPEKEGL LARRLGVLYG TNIDLADEME LEALEPLTSQ
     EPFNTDCERA QYLQEPPVQN TIVVPAEITS EELLHSAPNQ DPLPLQANLR EPLV
//
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