ID A0A096LWA2_POEFO Unreviewed; 833 AA.
AC A0A096LWA2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023443.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AYCK01009704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LWA2; -.
DR Ensembl; ENSPFOT00000024664.1; ENSPFOP00000023443.1; ENSPFOG00000007247.2.
DR GeneTree; ENSGT00940000161685; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 94..405
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 21..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 112..181
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 210..248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 289..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 467..492
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..578
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..664
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 92657 MW; CD8B6882364B0418 CRC64;
MSYPVDTIGS PFRRVMDTRT TSYGYGRPSG TPSSGFRSQS WSRTSPGSTM TASYKRTVNA
PAPRAYSSTV LSSADSVDYS QTSILNGDYK RSNEKEQLQG LNDRFVVYID KVHYLEQQNK
QIEAEIQALR QKQVSRNQLD DLYDQELKEL RTVLEQIHRD KAQVQLDTEH IEEDIQRLRD
RFEEEARIRE ETEAIIRVLK KDTGDSELVK SELDKKVQSL QDEIAFIRNN HEEEVSDLIA
QIQASQVTVE RKDLQKTDIT EALREIRTEL EGHSNQNLQQ VESWFMCRYA KLTEAAEQNK
DAIKSARDEI ADYRRQLQAK TVELESVRGM KDSLERQLND IEDRHNSDLA SLQETIHQLD
NELKSTKWEM ARHLREYQDL LNVKMALDIE IAAYRKLLEG EETHFSSFPY RQAVTPSKIS
KPKSEASKLK VQHKFVEEII EETRVEDDKV DIDEALAEIA QELSAAPGEE GEEEEGGEEE
QDAEEEAAEE EEIVAATEAK VSASAPSKDE DEEEKGDEEG DEEGGEGGEE EEVEETVLCS
KAPESKASPD KEKDGEKEGS AGEEEEAVAE EEGAEKEEES ADDKASKSVD ESESPKPGSP
KSESPKPGSP KSESPKPGSP KSESPKPGSP KSESPKPGSP KSESPKPGSP KSESPKPVSP
KTESPKPESP KAESPKSASP KPESPKESSP KAESLKPSSP KSESPKSDTT KAEAPKDDKS
EKKSDSTEDK KVEKKDVAMN GEVEKSSPEE KEKKDADVIA NGVDESPVKE DGSQKVVITK
TVETITTGED GSKHVTKSIT VTETVKEVEE VLQEKLVSTK KTEKQSTQSV KEV
//
