ID A0A096LWF8_POEFO Unreviewed; 1145 AA.
AC A0A096LWF8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Mcf.2 cell line derived transforming sequence-like b {ECO:0000313|Ensembl:ENSPFOP00000023499.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSPFOP00000023499.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000023499.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000023499.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01006177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096LWF8; -.
DR Ensembl; ENSPFOT00000028317.1; ENSPFOP00000023499.1; ENSPFOG00000016374.2.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd11857; SH3_DBS; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR035532; DBS_SH3.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 13..185
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 590..770
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 782..904
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1058..1119
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 539..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..953
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 129718 MW; B5F4F0FBE22F6CC6 CRC64;
MALGELLERL RSVTQTIDEI MQLDTNPPRA ADITADLRKQ FAFLSGGRGD NGSPIIVFPE
FPAFGEITDR EFHNVLTYLT SVPSLSSTDV GFILVIDRRQ DRWAAVKGTL LRIAGSFPGN
LQLVLVLRPT TLLQRTLSDI LFKFNKDEFK MKVPVVMLSS VSELHSYIDR TQLTRELGGT
QDYCHEKWIS HRTAIEGFAL MVKRTAQTLQ SFGTELAETE LPNEIQTTTV LLSTHTSKRD
KMKEDILVAL DQGSRLLESI NEPVMRDPDH NMNQDELENL ATVQRLLSQL DETERAFDEF
WVRHQTKLEQ CLQLRHFEHN YREVRGLLDN LSEKLVTFSE VGISPAHADH IFCELTSFEE
RVCEVLDRAS ALSREGDELI QKSHYAEDSI QPKCSELRAI SESLSCSLST KKDYLLRAME
LHRRLERASK WVDDGIYLLA SQPVDKCQSH EGAELALQEL ERYLDNAGQN QLTELDAIWK
EYEEVLSQQF RAWQEQVEKV YQKQTSMQEM FDKRKISLKK LAAKQTRPVQ PVAPRPEAFI
KSPLSSPGEP PHCISPTSRF TAQKNGQLQN EDGGSRHASQ SEEEENLAVL RRHVMNELLE
TERAYVEELL CVLQGYASEM DNPAMSHLIP APLQNKKEVL FGNMPEIYHF HKRTFLRELE
LYTDCPELVG RCFLERMTDL QIYEKYCHNK PRSESLWRQC SDCAFFQECQ KKLEHKLGLD
SYLLKPVQRI TKYQLLLKEM LKYSKGCDGA DDLQEALTSI LGILKAVNDS MHLIAITGFE
GNMSELGKLL MQGSFSVWTE HKKGHAKVKD LARFKPMQRH LFLHEKALLF CKRREENGEG
YEKAPSYSFK QSLSMNAVGF TENAKGDNKK FEIWSSSREE VYIVQAPTAE VKTTWVNEIR
KVLTTQLEAC REASQQRAPD QVFPFPPLPT GTDKDKSTSQ KVKKGEEKKA EPCSPDVIST
CSPKLTVKAG SDEAVTSPTS DRAAAAKKRF TLQGFSNLKT QKGSPTSPDH NTKRQSDPTP
FGFKGWNKTS LSLDEHDGYS SAEEPLNSDP EEENHKKLCA GKYTVMADYE NGAADELLVK
SGDMVQLVKE GDDGQWFVRN LNTSKEGWMA AANLMTLMEK SKSCQSLSSS EGSGNLSTSS
SCSEA
//
