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Database: UniProt
Entry: A0A096LZA3_POEFO
LinkDB: A0A096LZA3_POEFO
Original site: A0A096LZA3_POEFO 
ID   A0A096LZA3_POEFO        Unreviewed;      1570 AA.
AC   A0A096LZA3;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000024494, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000024494, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000024494};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000024494}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000024494}.
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DR   EMBL; AYCK01010472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000030279; ENSPFOP00000024494; ENSPFOG00000018180.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     49     69       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    191    218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    411    429       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    479    500       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    521    549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    611    634       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    851    869       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    890    908       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    967    993       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1092   1116       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1178   1196       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1238   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1295   1323       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1395   1421       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        8    223       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      411    638       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      647    844       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      849   1125       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1177   1431       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1435   1493       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      219    249       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1570 AA;  180170 MW;  5EBDBC7802019DF0 CRC64;
     YLTEFVDLGN VSALRTFRVL RALKTITVIP GLKTIVGALI QSVKKLRDAM ILTVFCLSVF
     ALIGLQLFMG NLRQKCVLIP PLLRNDTSEG AFNISFHENN SSDFDFYTHI NNPDNYYHLP
     GQLDALLCGN SSDSGTCPDG YMCLKAGRNP NYGYTSYDSF SWAFLSLFRL MTQDFWENLF
     HLTLRAAGKT YMIFFVVIIF LGSFYLINLI LAVVAMAYAE QNEANIAEAK QKEEEYAQIL
     EALKQREEEV RCDEEKPPMT FQDKAECLFV FCLHSKRPRG RRSWRIKTPH HKAKRSIRTW
     KVLRLTERTG VIDSGSATHN KSSERSILGT NPMMDHQMSE FEVLKKFAPF RLVLSDAFHL
     TQQLCVSEFE DDQRPCPPCW YMFANIFLKW DCCGCWRWLK KLLYTIVMDP FVDLAITICI
     VLNTVFMAME HYPMTEEFED LLSTGNLVFT GIFTAEMVLK LLAMDPYYYF QVGWNIFDSI
     IVTMSLVELG LANVQGLSVL RSFRLMRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA
     IIVFIFAVVG MQLFGKSYKD CVCRIAEDCE LPRWHMNDFF HAFLIIFRVL CGEWIETMWD
     CMQVAGEPMC LIVFMMVLVI GNLVVLNLFL ALLLSSFSGD NLAVTEDEGE NNLQIAINRI
     SRAVAWTKAW FLKHIWTLVG KKTNVNSDLF LSLYLKSMFL AVPCEEGEKS KEVLSLTIVN
     SEQPMVQVPK VDLSFLSSYY HNITCLKVPI AEAESDFDMP ENEDDEDEDN EEDDTEDELS
     QAQGDESSIC STVERAPEVQ KIEEVEETPE DCYTEKCYNR CPCLDIDTTQ SKGKIWFNFR
     KTCFTIVEHN YFETFIIFMI LLSSGALAFE DIYIEQRRVI KIILEYADQV FTYVFVVEMI
     LKWVAYGFKT YFTNAWCWLD FLIVDVSLVS LTANILGYSE LGAIKSLRTL RALRPLRALS
     RFEGMRVVVN ALVGAIPSIF NVLLVCLILW LIFSIMGVNL FAGKFYYCFN ETSEEYFFPE
     EVNNKTQCLD LIEKGFSEVR WKNTKINFDN VGMGYLSLLQ VATFKGWMDI MYAAVDSREV
     ESQPMYEDNL YMYMYFVCFI IFGSFFTLNL FIGVIIDNFN QQKAKAVYLG GTDIFMTEEQ
     KKYYNAMKKL GSKKPQKPVP RPTNKFQGLV FDLVTKQFFD ILIMVLICLN MVTMMVETDE
     QSPEKENILY WVNLVFIVIF STECCLKMIA LRKHYFSVGW NIFDFVVVIL SIVGLLLADI
     IEKYFVSPTL FRVIRLARIG RILRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLIMFIF
     SIFGMSNFAY VKKESMIDDI FNFESFGNSM ICLFMITTSA GWDGLLNPIM NTPPDCDPDF
     ENPGTSVRGN CGSPAVGIVF FTSYIIMSFL VVVNMYIAII LENFNVATEE SADPLSEDDF
     DMFYETWEKF DPRASQFIHY SELSDLCDTL QDPMRIPKPN TIKLMQMDLP LVPGDKIHCM
     DILLALTAEV LGESEAMDAL KATIEDKFMA NNPTKKLYEP ISNTLRKKHE DLAATVIQRA
     YRRCLLQRVI
//
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