ID A0A096M5H0_POEFO Unreviewed; 1865 AA.
AC A0A096M5H0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000026661.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000026661.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; AYCK01006669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000026383.1; ENSPFOP00000026661.1; ENSPFOG00000009012.2.
DR GeneTree; ENSGT00940000158289; -.
DR OMA; NFADHRP; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180, ECO:0000256|PIRSR:PIRSR602077-
KW 3}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1120..1142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1162..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1193..1211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1280..1298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1372..1395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1411..1446
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 742..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1630..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1808..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1820..1835
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 298
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 621
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1023
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1865 AA; 212043 MW; 90CE8DEF034ECF0E CRC64;
MATNTDAAKP VIMNEEELKK KQREKLKRLQ ATGGNPRPAR TLFLFSLKNP FRKACINIVE
WKTFEIIILL TIFANCVALA VFLPMPEEDS NNTNTNLESL EYIFLVVFTF ECFMKIIAYG
LVFHEGAYLR NCWNILDFVI VFMGLLDTIN MIAGVEKEKG GGFDMKALRA FRVLRPLRLV
SGVPSLQVVM NSILKAMLPL LHIALLVFLL VTIYAIMGLE LFKCKMHKTC YYTGTTTDIY
AAAEGELPAP CAQAGNGRRC MINGSECRPN WEGPNNGITH FDNIGFAMLT VYQCITMEGW
TKVLYWVNDA IGNEWPWLYF VPLILLGSFF VLNLVLGVLS GEFTKEREKA RSRGEYQKLR
ERQQLDEDLH GYMEWITHAE VLDADREGKG LLPLTSGDSD TDSLYDLEGK SRIIYYYRLG
LRWNRFFRMK CLIYVKTKSF YWAVMFLVFL NTLTIATEFH HQPDSLTSLQ ADVASRVLLV
LFVFEMLVKM YALGPRAYFM SLFNRFDFFV VLCGILEMIM LSAGAVAPLG FSVLRCIRLL
RIFKVTKYWT SLSNLVASLL NSVRSIASLL LLLFLFIVIF SLLGMQVFGG KFNFDYNRPR
RSNFDNFPQA LISVFQILTG EEWTNIMYNG IMAYGGPEIP GILVSIYFII LFVCGNYILL
NVFLAIAVDN LAEAESLTSA QKEKAEEKMR KKLLRSKMPE KTDEERERIA KKLAEQRAKM
EGMPTTAKLK IDEFESNVNE VKDPFPPADF PGDDEEEEPE IPISPRPRPM ADLQLKEEAV
PLPEASSFFI FGPQNKFRKL CYKIINASSF TNLILLFILL SSISLAAEDP IDPKSYRNQI
LAYADIVFTT VFTIEIVLKM TVYGAFMHEG SFCRNSFNIL DLIVVTVSLL SMGMESSAIS
VVKILRVLRV LRPLRAINRA KGLKHVVQCV FVAIKTIGNI VLVTMLLNFM FACIGVQLFK
GKFYSCTDPT KLTAEECQGR YLKHMENSLQ DTVLAKRQWI NSDFNFDNVL NGMLALFTVS
TFEGWPKLLY RAIDSAEEDM GPVYNNRVDV SIFFIIYIIL IAFFMMNIFV GFVIVTFQEQ
GEQEYKNCEL DKNQRQCVQY ALKARPLRCY IPKNPYQYRV WYIVTSCYFE YLMFFLIMLN
TLCLGMQHCN QSNYVTKLSD TLNLIFTVLF TVEMILKLMA FKVRGYFGDP WNVFDFIIVI
GSVVDVILSE VDAALDSSGG LYCLHGCAET DPMEEIAASE NASVSITFFR LFRVMRLVKL
LNRSEGIRNL LWTFIKSFQA LPHVALLIVM LFFIYAVIGM QIFGKVALVD GTQINRNNNF
QTFPQAVLML FRCATGEAWQ DVMMASMYGK MCDPKSDFLP GEEYTCGSNF AVFYFLSFYC
LCAFLILNLF VAVIMDNFDY LTRDWSLLGP HHLDEFKKIW AEYDPEATGR IKHLDVVTLL
RRIQPPLGFG KFCPHRAACK RLVGMNMPLN SDGTVTFNAT LFALVRTALK IKTEGNFEQA
NEELRAIIKK IWKRTSMKLL DQVIPPIGDD EVTVGKFYAT FLLQDHLRKF LKRQEEYYGY
RPSKKSTSGP EIQAGLRSIE EEAAPEMHRA ISGDLQNEEE MDRAMDEAAE ETIYQRSHGL
FGNRVESFSA EAADAQSSQM THQRPLQFSE SQSESPPNSS ALAPSADFFP ATAPKSNTNN
NAFAEFFFDR EASPGRGTRC DRGHETPRVM SAHTAWGSRV KDKDPRHSWS FTVKTNKTQF
PYEPEWMESR SRSSKTAADQ LVQEALEMGG LASLSKDPAF VSVTKKEMAD AMHMPVSEME
GVARGILSER SDSVPSVKKR RPVPVPPPVP AGGGQRPGQP EPAVRKKRRP VPTVPSRKKR
DDSEV
//