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Database: UniProt
Entry: A0A096M5H0_POEFO
LinkDB: A0A096M5H0_POEFO
Original site: A0A096M5H0_POEFO 
ID   A0A096M5H0_POEFO        Unreviewed;      1865 AA.
AC   A0A096M5H0;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000026661, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000026661, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000026661};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000026661}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000026661}.
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DR   EMBL; AYCK01006669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000026383; ENSPFOP00000026661; ENSPFOG00000009012.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; FVIVFMG; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     63     82       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    102    123       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    284    305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    317    339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    439    457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    494       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    566    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    642    668       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    810    828       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    840    862       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    926    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1077       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1120   1142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1162   1181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1193   1211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1280   1298       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1372   1395       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1411   1446       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1865 AA;  212043 MW;  90CE8DEF034ECF0E CRC64;
     MATNTDAAKP VIMNEEELKK KQREKLKRLQ ATGGNPRPAR TLFLFSLKNP FRKACINIVE
     WKTFEIIILL TIFANCVALA VFLPMPEEDS NNTNTNLESL EYIFLVVFTF ECFMKIIAYG
     LVFHEGAYLR NCWNILDFVI VFMGLLDTIN MIAGVEKEKG GGFDMKALRA FRVLRPLRLV
     SGVPSLQVVM NSILKAMLPL LHIALLVFLL VTIYAIMGLE LFKCKMHKTC YYTGTTTDIY
     AAAEGELPAP CAQAGNGRRC MINGSECRPN WEGPNNGITH FDNIGFAMLT VYQCITMEGW
     TKVLYWVNDA IGNEWPWLYF VPLILLGSFF VLNLVLGVLS GEFTKEREKA RSRGEYQKLR
     ERQQLDEDLH GYMEWITHAE VLDADREGKG LLPLTSGDSD TDSLYDLEGK SRIIYYYRLG
     LRWNRFFRMK CLIYVKTKSF YWAVMFLVFL NTLTIATEFH HQPDSLTSLQ ADVASRVLLV
     LFVFEMLVKM YALGPRAYFM SLFNRFDFFV VLCGILEMIM LSAGAVAPLG FSVLRCIRLL
     RIFKVTKYWT SLSNLVASLL NSVRSIASLL LLLFLFIVIF SLLGMQVFGG KFNFDYNRPR
     RSNFDNFPQA LISVFQILTG EEWTNIMYNG IMAYGGPEIP GILVSIYFII LFVCGNYILL
     NVFLAIAVDN LAEAESLTSA QKEKAEEKMR KKLLRSKMPE KTDEERERIA KKLAEQRAKM
     EGMPTTAKLK IDEFESNVNE VKDPFPPADF PGDDEEEEPE IPISPRPRPM ADLQLKEEAV
     PLPEASSFFI FGPQNKFRKL CYKIINASSF TNLILLFILL SSISLAAEDP IDPKSYRNQI
     LAYADIVFTT VFTIEIVLKM TVYGAFMHEG SFCRNSFNIL DLIVVTVSLL SMGMESSAIS
     VVKILRVLRV LRPLRAINRA KGLKHVVQCV FVAIKTIGNI VLVTMLLNFM FACIGVQLFK
     GKFYSCTDPT KLTAEECQGR YLKHMENSLQ DTVLAKRQWI NSDFNFDNVL NGMLALFTVS
     TFEGWPKLLY RAIDSAEEDM GPVYNNRVDV SIFFIIYIIL IAFFMMNIFV GFVIVTFQEQ
     GEQEYKNCEL DKNQRQCVQY ALKARPLRCY IPKNPYQYRV WYIVTSCYFE YLMFFLIMLN
     TLCLGMQHCN QSNYVTKLSD TLNLIFTVLF TVEMILKLMA FKVRGYFGDP WNVFDFIIVI
     GSVVDVILSE VDAALDSSGG LYCLHGCAET DPMEEIAASE NASVSITFFR LFRVMRLVKL
     LNRSEGIRNL LWTFIKSFQA LPHVALLIVM LFFIYAVIGM QIFGKVALVD GTQINRNNNF
     QTFPQAVLML FRCATGEAWQ DVMMASMYGK MCDPKSDFLP GEEYTCGSNF AVFYFLSFYC
     LCAFLILNLF VAVIMDNFDY LTRDWSLLGP HHLDEFKKIW AEYDPEATGR IKHLDVVTLL
     RRIQPPLGFG KFCPHRAACK RLVGMNMPLN SDGTVTFNAT LFALVRTALK IKTEGNFEQA
     NEELRAIIKK IWKRTSMKLL DQVIPPIGDD EVTVGKFYAT FLLQDHLRKF LKRQEEYYGY
     RPSKKSTSGP EIQAGLRSIE EEAAPEMHRA ISGDLQNEEE MDRAMDEAAE ETIYQRSHGL
     FGNRVESFSA EAADAQSSQM THQRPLQFSE SQSESPPNSS ALAPSADFFP ATAPKSNTNN
     NAFAEFFFDR EASPGRGTRC DRGHETPRVM SAHTAWGSRV KDKDPRHSWS FTVKTNKTQF
     PYEPEWMESR SRSSKTAADQ LVQEALEMGG LASLSKDPAF VSVTKKEMAD AMHMPVSEME
     GVARGILSER SDSVPSVKKR RPVPVPPPVP AGGGQRPGQP EPAVRKKRRP VPTVPSRKKR
     DDSEV
//
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