ID A0A096M6L8_POEFO Unreviewed; 561 AA.
AC A0A096M6L8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Ras protein-specific guanine nucleotide-releasing factor 2a {ECO:0000313|Ensembl:ENSPFOP00000027059.1};
GN Name=RASGRF2 {ECO:0000313|Ensembl:ENSPFOP00000027059.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000027059.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000027059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01029333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A096M6L8; -.
DR STRING; 48698.ENSPFOP00000027059; -.
DR Ensembl; ENSPFOT00000022558.1; ENSPFOP00000027059.1; ENSPFOG00000021779.1.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000155679; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 62..248
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 561 AA; 64274 MW; AFFB9E0075B92D3D CRC64;
IVVLNKAKER MFPFQSNQEE EDPDIKKIKK VQSFMRGWLC RRKWKIIVQD YICSPHAESM
RKRNQIVFNM VEAETEYVHQ LSILVNCFLR PLRMAASSKK PPISHDDVSS IFLNSETIMF
LHEIFHQGLK ARIANWPTLV LADLFDILLP MLNIYQEFVR NHQYSLQVLA NCKQNRDFDK
LLKQYEYNAG CEGRMLETFL TYPMFQIPRY IITLHELLAH TPHEHVERKS LEFAKSKLEE
LSNRMMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF VRQGSLPAFS AFVQPSHLPA
LFHDFSPPRS GSLIQLPSSS ERGMLSKVRL GSLSLSRIEV DVCCRTAMET PFSHHTSHMI
SSWMLLLAKT KWIVSLNLFR TYPCILGDES FFFPLQCIDN IRCNGLMTSV FEENSKVSVP
HMINRPTFLH SFTTSLLHDQ VLSSSCRPAA NGACSVRISL METWHQGGTL SLIECTLIEE
LDASDEDYNA AGQGFSHLEF KIVVEPPDGQ SFCVVLLAPS RQEKAAWTSD ISQCIDNIRC
NGLMTSVFEE NSKVSVPHMI K
//
