ID A0A096MAX9_POEFO Unreviewed; 1343 AA.
AC A0A096MAX9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSPFOP00000028570.1};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSPFOP00000028570.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000028570.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000028570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01003383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01003384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000030068.1; ENSPFOP00000028570.1; ENSPFOG00000006665.2.
DR GeneTree; ENSGT00940000153798; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT DOMAIN 399..586
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1343 AA; 148667 MW; 40F80E3AC474D7BF CRC64;
FNQRSALDTS PHNLKIKDPT YNVPFDDEDE GEPFDFDSGD DIPEAPPAPP SFPSEDPSQA
NSVTGHPEGS YSNLDPPAQF SNLAPTPMSK VNPYSVIDIT PIQLQQEQQH GPSSSTSSPR
ESITSGYSVP VPCGYATPSG VPLITPAYTT PVIIRHLSVD EDVTVVGTSN TSADSVFSEE
NPAIAEEDAL AKWASDPANT AWMENPDEVI YDDVPRENSD SNTDPDEMIY DDVELGEEGG
CSSSLDNGWS SSEFESYDEA SDGEDRPENG LPHAFMRGRK QKQLSQDLTR LKEHYEKKMK
ELMASTVGAV ELQQLKQKHE QKMQKLVKAA KEGTKDGLEK TKAAVKRGRS FIKTKSFCQE
RKLACFEDES EVFIEVDCFN NVEPVLPPTP QGLSQQQLVR RCILGSILDS EKNYLDALKR
ILEQYEKPLS QIEPRLLSDR KLKIIFYRVR EILQCHFLFQ IALASRVSEW DSLEMIGDVF
VASFSKSMVL DAYSEYVNNF STAMAVVRKT CASKPSFLEF LKHRQESSSD RMTLYGLMMK
PIQRFPQFIL LLQDMLKNTP VGHADRLPLQ MALTELETLA EKLNEKKREA DQRCEIRHIA
KAMNERYLNK LLSNGSRYLI RSDDMVETVY NERGEIIKTK ERRLFLLNDV LMCATPNIRG
SGSGNAPFDQ KFLLKWSVPL NFVEVLEFGS SEEMVDNSRY PAPHSGEKVV INAKPNKLYM
GPGQLYQDLQ NLIHDLGLVN QIAGMIGSLK GNYQNVNSTV AQDWVSGLQR LILKKEEEIR
AADRCRIQLQ LPGKNDKAGK PTYFSAVFNT LSPAIKQSWI SNLQMAKLAL EEDNLQGWFF
ADDDGNHIKK QKHPLLLRQM PVVMSKLQEF KVECAVHNPE PYINTESTAD SPVVGHGCVW
VASCTNQMGQ IAIVAMQNSC PKVTECFNVE SRILCMAYVP TEQLKEDGEK LPDSNYAPPA
KASDTPTVCL GMEEGSIIVY KSTQRSKKIR LQHFFTPDKS TVTSLVYKKP CLYAGLVSGA
VAIYSRSQDG SWSCEKPKLL KLGVLPVKAV LAVEDHLWAS SGGQVFIIGT HTHCVERQLE
AHQEEGMVVS HMVVAGVGIW IAFSSGSTVR LFHTETLEHL QDINIATTVN NILPGNQRVS
VSSLLVCHGL LLAGTNLGVT VALSVPRLQG IPKVTGRGMV SLHAHNGPVK FLTMATAVRN
WSSSLPSSTP SSSLQQIESV DADSAQPVSD TASSPPQGRG VWLGEAGCTT MALQDSLSSS
SCGSLAPSQG SLEHGPEDGA LYDLLHDPAH HQRGRRSSKM DVSSLLVVSG GLGHRRVNKK
TKQSRHEDNT STIMIWQIPL LNM
//
