ID A0A096MCM2_POEFO Unreviewed; 1605 AA.
AC A0A096MCM2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP6 {ECO:0000313|Ensembl:ENSPFOP00000029163.1};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029163.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000029163.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; AYCK01010885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01010890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000027161.1; ENSPFOP00000029163.1; ENSPFOG00000016583.2.
DR GeneTree; ENSGT00940000155797; -.
DR OMA; FKADNRR; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028135; Ub_USP-typ.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF76; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 32; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF14836; Ubiquitin_3; 1.
DR Pfam; PF00443; UCH; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00695; DUSP; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 228..263
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 264..299
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 369..584
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 733..1568
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 440..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1369..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1404..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1605 AA; 180184 MW; 0456C21B99AA1392 CRC64;
MGAKESRIGF LSYDEAVKRV TDVELKRLKD AFKRTSGLSC YMTQQCFYRE VLGDGVPPKV
AEVIYSSFGG SSKGLHFNNL IVGLVLLTRG RDEEKAKYLF SLFASDLSGY AAREDIEAVL
QALDGEVPSS LKRCFIESDK VNYERFRNWL LQNKEAFTLS RWLLSGGVCV TLTDDSDTPT
FYQTLAGVTH LEESDIIDLE KRYWLLKAQS RTGRFDLETF VPLVSPPIHA SLSEGLFHAF
DENRDNHIDF KEISCGLSAC CRGPVAERQK FCFKVFDVDR DGVLSRDELH EMVVALLEVW
KDNRTDTIPE LHSSVSDIVE EIVKMHDTTK LGHLTLEDYQ IWSVKSALAN EFLNLLFQVC
HIVLGLRPAT PEEEGQIIRW YLERESRHGL QQGQSWFLIS MLWWQQWKDY VKYEHKDIVV
EQPSILSSLR PLTVTATVEP AHPDMPGGLG TFGPFSPSEE KSPDAVSSAS EATETALSPQ
LGPSSAESCF ARQHNISENN NQCFSGANGH LPSQLTAQRP GAIDNQSLVT TDPIKAPTLT
MEGGRLKRSL QLVPGRDFEM MPEPVWRALY HWYGANLSLP RPVILESKTG QAELELFPRY
LLFLRQQPAT RSPQSNIWVN MGNVPSPNAP LKRMLAYTGC FSRMATIKDI HLYLSQRLRI
KEEDMRLWLY NSENYLTLLD DEDHTLESLK IQDEQQLVIE VRNKDMSWPE EMSFIANSSK
MDRHKVPTEK GATGLSNLGN TCFMNSSIQC VSNTKPLSDY FLSGRHLYEL NRINPIGMRG
HMAKCYGDLV LELWSGTQKS IAPLKLRWTI AKYAPRFNGF QQQDSQELLA FLLDGLHEDL
NRVHEKPYVE LKDSDGRPDW EVASEAWDNH LRRNRSIVVD LFHGQLKSQV KCKTCGHISA
RFDPFNFLSL PLPMDSSMHL EITVIKLDGS TPVRYGLRLN MDEKYTGLKK LLSELCSLKP
EQILLAEVHA SNIKNFPQDN QKVRLSVNGF LCAFEVPVPG SPTSLSSPTL TGYSPVAADF
SRTGGLHVQP DITPTAANGH LIANGGLGTL LPSTPETPLV NGVANGHISP LQDSPFIGYI
IAMHRKMMRT ELYFLSSQKN RPSLFGMPLI VPCTVHTSKK DLYDAVWIQV SRLASPLPPQ
EASNHAQDCD DSMGYQYPFT LRVVGKDGNS CAWCPWYRFC RGCTIECTED RASVGNAYIA
VDWDPTALHL RYQTSQERIV EEHCSVEQSR RAQAEPISLD SCLKAFTSEE ELGEDELYYC
SKCKTHRLAT KKLDLWRLPP ILIVHLKRFQ FVNGRWIKSQ KIVKFPQESF DPSAFLAPRD
LEHRSLHSRS ESEDLLREIL SLDSQSTPLS AVLSTIVSHL FTLNITSPAS SRRSAPSLSR
NSSPSGSPKP AGHRPGRLRL PQLSSKHRLS SSKENLDGAA SSEADSRDGA PQADTEERVA
IAAGAGPVGY SDQAASESSC SREASSSYCD VILMNGDSNG MGSDCSIESN VDPDSSLLQH
RDMCLDPLYN LYAISCHSGI MGGGHYVTYA KNPNDKWYCY NDSSLEGHEV HSEEIDTDSA
YILFYEQQGV DYSQFLPKID GKKMADTSSM DEDFESDYKK YCVLQ
//