ID A0A096ME75_POEFO Unreviewed; 1932 AA.
AC A0A096ME75;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000029716.1, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000029716.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AYCK01002216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01002217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPFOT00000031200.1; ENSPFOP00000029716.1; ENSPFOG00000016943.2.
DR GeneTree; ENSGT00940000163423; -.
DR OMA; KDFPKNG; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 133..151
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 163..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 194..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 404..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 706..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 736..756
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 768..792
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 813..841
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 903..926
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1144..1162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1183..1202
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1208..1229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1260..1286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1379..1403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1453..1475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1495..1514
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1526..1545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1579..1607
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1685..1708
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 132..434
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 553..618
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 702..931
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 940..1138
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1142..1412
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1461..1718
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 31..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1882..1932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 439..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1910..1932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1932 AA; 220266 MW; 0154CB0991D1CA69 CRC64;
MAELPVAAGP DSFRPLTRES LKVIEKRIAE KKAKKSNDEE KKHQYEDEVK PSRDLEAGKP
LPFLYDIPAG LMSKALEDLD PYYSNQKTFI VVNNKKLIYR FNAASALYLL SPFNPIRRLS
FKILVHPYPF SNLFNMLIMC TILINCGFMT LSNQPDFAKQ VEYTFTAIYT FEFVVKVLAR
GFCIGKFTFL RDPWNWLDFC VIVLAYVTEF ADIGNLSVLR TFRVLRTLKA ISVIPGLKTI
VGALFQSVKK LTDVMILTVF CLSVFALVGL QLFMGNLRNK CIRISEDTNL TFDESYINNR
SEFSIFYFCF SLKTKTFSQR PSEKLLSNQY ILQGKRDALL CGNSSSAGQC PEGFRCLKGG
KNPDYDYTSF DNFGWAFLSL FRLMTQDYWE YLYQQTLRVA GKPYMIFFVL VIFLGSFYLI
NLILAVVAMA YEEQCQVNLK KAQEKEYEYN IAIEQLKRQQ EDAQAMAKAA AATNGDALDK
GGGTESSSEV SKLSSKSAKE RRNRRKKRKE EEKGARKISH SDSLDSLPAN RFHFSVDEHP
LNYDMKCSST HQSFLSFRGP LLSSRRHSKT SLFSLQSQTQ DVASENEFAD DENSIFEGKL
SWRGSPLNAS RRDRHSSSAD TTDTEGKPTS GENYLNSLEL PEMRQRALSI ASVITTTMEE
LEESRQKCPP YWYKFADKFL IWECCPLWLK IKEIVKIIVM DPFTDLAITL CIVLNTVFMA
MEYYPMDPWF TDMLYVGNLV FTAIFTAEMV LKVIALDPYH YFQVGWNIFD GVIVCLSLIE
LSLADVKGMS ILRSFRLLRV FKLAKSWPTL NKLIKIIGNS VGALGNLTLV LAIIVFIFAV
VGMQLFGKYY KDCVCKISED CTLPRWHMND FFHSFLIVFR VLCGEWIETM WDCMEVAGKA
PCLILYMTVM VIGNLVVLNL FLALLLSSFS ADNLMSGEDD NELNNLQIAF DRIHRAIAFI
KLKFRSCCNG LCIRDKKTTE DKTFGHNGVP NHTIKDLTKN SNGEVTGVDK SGNKYIVNSR
SDDSIMSFIN NPSLTVTVPI AAEESDFEML NTEDFSSFSS NIPECHMGKS APSTSEGSTV
DGLSNGEPAE LVPVVEVIKE PHDCFTAAGC IQKCKCCQVN ANVGWWKVWW TLRKTCYRIV
EHNWFESFII FMILLSSGAL AFEDIYSEQR KTIKVILEFA DKMFTFIFIL EMLLKWMAYG
FAKYFTNAWC WLDFLIVDVS LVSLVANALE YSELGPIKSL RTLRALRPLR ALSRFEGMRV
VVNALMGAIP SIFNVLLVCL IFWLIFSIMG VNLFAGKFYR CENTTTEKPF LPTEVKNETE
CKSYGVWKNV KVNFDNVAMG YLALLQVATF KGWMDIMYAA VDSQSKAGDQ PEYEINLKMY
IYFVVFIIFG SFFTLNLFIG VIIDNFNQQK RKLGGQDIFM TDEQKKYYNA MKKLGSKKPQ
KPIPRPENKL QGYVFDFVTQ QVFDIAIMVL IWLNMVTMMV EVEGQSKEWE KNLKYINIVF
IIIFSGECLL KMIALRQYFF INGWNIFDFI VVILSIVGIF LANVIEKYFV SPTLFRVIRL
ARIGRVLRLI KSAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKKEKG
IDDLFNFETF GNSMICLFQI TTSGGWDLLL APILNTKDNS DCDSEMEHPG SNNAKGNCGN
PAVGIAFFVS YIIICFLIVV NMYIAVILEN FGVATEESAE PLSEDDFEIF YEVWEKFDPL
ATQFVKYSML SDFADSLAPP LRIPKPNKLE LISMDLPVVS GDRIHCLDIL FAFTKRVLGE
SGEMDILRGQ MEERFMAANP SKVSYEPITT TFRQKQEDAS AAVIQRAFRH YTRTKIFDVV
RVDIEKDEQL TDKEDCCTEK PVELTTTHKT EVSGLKDSEP SSTSVTPNVN SKHEKDRSEK
EVESKDITEQ DK
//
