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Database: UniProt
Entry: A0A096MTC9_PAPAN
LinkDB: A0A096MTC9_PAPAN
Original site: A0A096MTC9_PAPAN 
ID   A0A096MTC9_PAPAN        Unreviewed;      1986 AA.
AC   A0A096MTC9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   30-AUG-2017, entry version 24.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSPANP00000003058};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000003058, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000003058, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000003058}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000003058}.
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DR   EMBL; AHZZ01053741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01053742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPANT00000001633; ENSPANP00000003058; ENSPANG00000010874.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000028761; Chromosome 12.
DR   ExpressionAtlas; A0A096MTC9; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    404    431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    766    784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    819       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    876    904       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    966    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1212   1230       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1251   1273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1299       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1449   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1753   1776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      135    438       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      512    715       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      766    994       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1003   1205       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1210   1481       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1786       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      428    476       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1986 AA;  224532 MW;  C207BCD1303964CF CRC64;
     MAQALLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENGTI NNSDSNSGFS
     LCQVLFPRSP PSLTHNPAAV ISFSYFLFQT FIVMNKGKAI FRFSATSALY ILTPLNPVRK
     IAIKILVHSY PFNNSMLIMC TILTNCVFMT LSNPPDWTKN VEYTFTGIYT FESLIKILAR
     GFCLEDFTFL RDPWNWLDFS VIVMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CLQWPPSDSA FETNTTSYFN
     GTMDSNRTFV NVTMSTFNWK DYIGDDSHFY VLDGQKDPLL CGNGSDAGQC PEGYICVKAG
     RNPNYGYTSF DTFSWAFLSL FRLMTQDYWE NLYQLTLRAA GKTYMIFFVL VIFLGSFYLV
     NLILAVVAMA YEEQNQATLE EAEQKEAEFQ QMLEQLKKQQ EEAQAAVAAA SAASRDFSGI
     GGLGELLESS SEASKLSSKS AKEWRNRRKK RRQREHHEGN NKGEKDSFPK SESEDSVKRS
     SFLFSMDGNR LTSDKKFCSP HQSLLSIRGS LFSPRRNSKT SIFSFRGRAK DVGSENDFAD
     DEHSTFEDSE SRRDSLFVPH RHGERRNSNV SQASMSSRMV PGLPANGKMH STVDCNGVVS
     LVGGPSALTS PTGQLLPEGT TTETEIRKRR LSSYQISMEM LEDSSGRQRA MSIASILTNT
     MEELEESRQK CPPCWYRFAN VFLIWDCCDA WLKVKHLVNL IVMDPFVDLA ITICIVLNTL
     FMAMEHYPMT EQFSSVLTVG NLVFTGIFTA EMVLKIIAMD PYYYFQEGWN IFDGIIVSLS
     LMELGLSNVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KSYKECVCKI NDDCTLPRWH MNDFFHSFLI VFRVLCGEWI ETMWDCMEVA
     GQTMCLIVFM LVMVIGNLVV LNLFLALLLS SFSSDNLAAT DDDNEMNNLQ IAVGRMQKGI
     DYVKNKIREC FRKAFFRKPK VIEIHEGNKI DSCMSNNTGI EISKELNYLR DGNGTTSGVG
     TGSSVEKYVI DENDYMSFIN NPSLTVTVPI AVGESDFENL NTEEFSSESE LEESKEKLNA
     TSSSEGSTVD VALPREGEQA EIEPEEDLKP EACFTEGCIK KFPFCQVSTE EGKGKIWWNL
     RKTCYSIVEH NWFETFIVFM ILLSSGALAF EDIYIEQRKT IKTMLEYADK VFTYIFILEM
     LLKWVAYGFQ TYFTNAWCWL DFLIVDVSLV SLVANALGYS ELGAIKSLRT LRALRPLRAL
     SRFEGMRVVV NALVGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYHCV NMTTGNMFDV
     SDVNNLSDCQ ALGKQARWKN VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRDVTLQ
     PMYEENLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPANKF QGMVFDFVTR QVFDISIMIL ICLNMVTMMV ETDDQGKYMT
     LVLSRINLVF IVLFTGEFVL KLVSLRHYYF TIGWNIFDFV VVILSIVGMF LAEMIEKYFV
     SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS
     NFAYVKKEAG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSAPPD CDPDTIHPGS
     SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE
     VWEKFDPDAT QFIEFSKLSD FAAALDPPLL IAKPNKVQLI AMDLPMVSGD RIHCLDILFA
     FTKRVLGESG EMDALRIQME DRFMSSNPSK VSYEPITTTL KRKQEEVSAA IIQRNFRCYL
     LKQRLKNISS NYNKEAIKGR IDLPIKQDMI IDKLNGNSTP EKSDGSSSTT SPPSYDSVTK
     PMKVKY
//
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