ID A0A096MV87_PAPAN Unreviewed; 3122 AA.
AC A0A096MV87;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Laminin subunit alpha 2 {ECO:0000313|Ensembl:ENSPANP00000003762.3};
GN Name=LAMA2 {ECO:0000313|Ensembl:ENSPANP00000003762.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000003762.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000003762.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000003762.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 9555.ENSPANP00000003762; -.
DR Ensembl; ENSPANT00000008210.3; ENSPANP00000003762.3; ENSPANG00000005014.3.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00940000155362; -.
DR HOGENOM; CLU_000301_0_0_1; -.
DR OMA; SHSRINF; -.
DR Proteomes; UP000028761; Chromosome 6.
DR Bgee; ENSPANG00000005014; Expressed in heart and 59 other cell types or tissues.
DR ExpressionAtlas; A0A096MV87; baseline.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
DR GO; GO:0043083; C:synaptic cleft; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IEA:Ensembl.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 15.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 15.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 16.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..3122
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035265098"
FT DOMAIN 35..286
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 414..468
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 469..517
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 538..723
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 757..806
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 807..864
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 865..917
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 918..966
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 967..1013
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1014..1059
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1060..1105
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1106..1165
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1180..1379
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1420..1468
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1527..1573
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2145..2328
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2340..2521
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2526..2711
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2763..2934
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2939..3119
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1682..1785
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1811..1887
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1981..2008
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2034..2140
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 414..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 444..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 488..497
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 776..785
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 835..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 889..898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 901..915
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 918..930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 920..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 939..948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 967..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 987..996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1060..1072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1062..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1081..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1106..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1136..1145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1439..1448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1527..1539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1529..1546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1548..1557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3122 AA; 344147 MW; 9A9BD1E5EBB34AA1 CRC64;
MPGAAGVLLL LLLSGGLRGG QAQRPQQQRR PQAHQQRGLF PAVLNLASNA LITTNATCGE
KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT NAIDGKNTWW QSPSIKNGIE
YHYVTITLDL QQVFQIAYVI VKAANSPRPG NWILERSLDD VEYKPWQYHA VTDTECLTLY
NIYPRTGPPS YAKDDEVICT SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY
IRLRFQRIRT LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA EECYYDENVA
RRSLSLNIHG KYIGGGVCIN CTQNTAGINC ETCIDGFFRP KGVSPNYPRP CQPCHCNPIG
SLNEVCVKDE KHARRGLAPG SCHCKTGFGG VSCDRCARGY TGYPDCKACN CSGLGSKNED
PCFGPCNCKE NVEGGDCSRC KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM
SGWYLTDLSG RIRVAPQQDD SDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG
QLTFTISYDL EEEEEDTEHV LQFMIILEGN DLRISTAQDE VYLHPSEEHV NVLLLKEESF
TIHGTHFPIS RKEFMTVLAN LKRVLLQITY SFGMDAIFRL SSVNLESAVS YPTDGSVAAA
VEVCQCPPGY TGSSCESCWP RHRRVNGTIF GGICEPCQCF GHAESCDDVT GECLNCKDHT
GGPYCDKCLP GFYGDPTKGT SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT
GPRCERCAEG YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL
CADGYFGDAV DARNCQPCRC NANGSFSEIC HSQTGQCECR ANVQGQRCDK CKPGTFGLQS
ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA HGYFSFQEGG CTACECSHLG
NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG HSITTGCKAC NCSTVGSLDF QCNVNTGQCN
CHPKFSGAKC TECSQGHWNY PRCSLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV
EGIHCDRCQP GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIWTWVTLKA EQTILPLVDE
ALQHTTTKGI VFQHPEIVAH MDLMREDLHW EPFYWKLPEQ FEGKKLMAYG GKLKYAIYFE
AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT RHEIEMTEKE WKYYGDDPRV
HRTVTREDFL DILYDIHYIL IKATYGNFMR QSRISEISME VAEQGRRTAV TPPAHLIEKC
DCPLGYSGLS CEACLPGFYR LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ
HHTAGDFCER CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVTEGLD DYRCTACPRG
YEGQYCERCA PGYTGSPSSP GGSCQECECD PYGSLPVPCD PVTGICTCRP GATGRKCDGC
KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG PLPAPYKMLY GLENTTQELK
HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL LTRATKVTAD GEQTGQDAER TNTRAKSLGE
FIKELARDAE AVNEKAIKLN ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA
EDELVAAEGL LKKVKKLFGE SRGKNEEMEK DLREKLADYK NKVDDAWDLL REATNKIRET
NLLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN SIIDYVEDIQ
TKLPPMSEEL NNKIDDLSQE IKDRKLAEKV SQAESHAAQL NDSSAVLDGI LDEAKNISFN
ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH EATKLATGPR GLLKEDAKGS LQKSFRILNE
AKKLANDVKE NEDHLNGLKT RIENADARNG DLLRALNDTL GKLSAIPNDT AAKLQAVKDK
ARQANDTAKD VLAQIKELHQ NLDGLKKNYD KLADSVAKTN AVVKDPSKNK IIADADATVK
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP
EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP
DLTIDDSYWY RIMASRTGRN GTISVRALDG PKASIVPSTY HSTSPPGYTI LDVDANAMLF
VGGLTGKLKK ADAVRVITFT GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT
IQFDGEGYAL VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA TSSSGNNFGL
DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE ISRTPYNILS SPDYVGVTKG
CSLENVYTVS FPKPGFVELS PVPIDVGTEI NLSFSTKNES GIILLGSGGT PAPPRRKRRQ
TGQAYYAILL NRGRLEVHLS TGARTMRKIV VRPEPNLFHD GREHSVHVER TRGIFTVQVD
ENRRYMQNLT VEQPLEVKKL FVGGAPPEFQ PSPLRNIPPF EGCVWNLVIN SVPMDFARPV
SFKNADIGRS VHQKLREDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP CAAESEPALL
IGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG LLFYMARINH ADFATVQLRN
GLPYFSYDLG SGDTNTMIPT KINDGQWHKI KIMRSKQEGI LYVDGASNRT ISPRKADILD
VVGMLYVGGL PINYTTRRIG PVTYSIDGCI RNLHMAEAPA DLEEPTSSFH VGTCFANAQR
GTYFDGTGFA KAVGGFKVGL DLLVEFEFRT TRTTGVLLGI SSQKMDGMGI EMIDEKLMFH
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS LNPASTSADT
NDPVFVGGFP DDLKQFGLTT SIPFRGCVRS LKLTKGTGKP LEVNFAKALE LRGVQPVSCP
AN
//
