ID A0A096MVR4_PAPAN Unreviewed; 1393 AA.
AC A0A096MVR4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=HFM1 {ECO:0000313|Ensembl:ENSPANP00000003955.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000003955.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000003955.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000003955.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR RefSeq; XP_017800061.1; XM_017944572.1.
DR STRING; 9555.ENSPANP00000003955; -.
DR Ensembl; ENSPANT00000013948.3; ENSPANP00000003955.2; ENSPANG00000009838.4.
DR GeneTree; ENSGT00550000074822; -.
DR HOGENOM; CLU_000335_0_0_1; -.
DR OMA; HCKNKHT; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000028761; Chromosome 1.
DR Bgee; ENSPANG00000009838; Expressed in optic disc and 61 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 248..436
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 477..678
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1065..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1393 AA; 158181 MW; B156E98863E4652D CRC64;
MIACFLWIIC FLKNQMKLKS QEKRPKMLTS NLKITNEGTN YISPTQKFQF AFPSDKYEQD
DLNLEGVGKN DLSHVAGKLT YGSEKYKNHI GTEIAPEKSV PDDTKLVNFA EDKGENTSVF
RKRLFKISDN IHRSAYSNDS ELDSHIGSVK IVQTEMNKGK SRNYSSSKQK FQYSANVFTA
NNAFSASEII EGMFKAPSFP VAFQPHDIQE VTENCLGSLK AVTEIPAKFR SIFKEFPYFN
YIQSKAFDDL LYTDRNFVIC APTGSGKTVV FELAITRLLM EVPLPWLNIK IVYMAPIKAL
CSQRFGDWKE KFGPIGLNCK ELTGDTVMDD LFEIQHAHII MTTPEKWDSM TRKWRDNSLV
QLVRLFLIDE VHIVKDENRG PTLEVVVSRM KTVQSVSQTL KNTSTVIPMR FVAVSATIPN
AEDIAEWLSD GERPAVCLKM DESHRPVKLQ KVVLGFPCSS NQTEFKFDLT LNYKIASVIQ
MYSDQKPTLV FCATRKGVQQ AASVLVKDAK FIMTVEQKQR LQKYAYSVRD SKLRDILKDG
AAYHHAGMEL SDRKVVEGAF TAGDLPVLFT TSTLAMGVNL PAHLVVIKST MHYAGGLFEE
YSETDILQMI GRAGRPQFDT TATAVIMTRL STRDKYIQML ACRDTVESSL HRHLIEHLNA
EIVLHTITDV NIALEWIRST LLYIRALKNP SHYGFASGLN KDGIEAKLQE LCLKNLNDLS
SLDLIKMDEG VNFKPTEAGR LMAWYYITFE TVKKFYTISG KETLSDLVTL IAGCKEFLDI
QLRINEKKTL NTLNKDPHRI TIRFPMEGRI KTREMKVNCL IQAQLGCIPI QDFALTQDTA
KIFRHGSRIT RWLSDFVAAQ EKKFTVLLNS LILAKCFRCK LWENSLHVSK QLEKIGITLS
NAIVNAGLTS FKKIEETDAR ELELILNRHP PFGTQIKETV MYLPKYELKV EQITRYSDTT
AEILVTVILR NFEQLQTKRT ASDSHYVTLI VGDADNQVVY LHRIMDSVLL KAGNWAKKIA
VKRALISEDL SINLLSSEFV GLDVQQKFTV FYLEPKRFEN QMTMQRKSET QISHSKLSDR
STVAGPNKGM TASKKLGNRE CNHPCKSKHT CGHDCCKIGV AQKSEIKEST ISSYLSDLRN
RNAVSSVPPV KRLKIQMNKS QSVDLKEFGF TPKPSLPSIS RSEYLNISEL PIMEQWDQPE
IYGKVRQEPS EYRDKEVLNV NFELGNEVRD DFDEENLEVT SFSTDTEKTK ISGFGNTLSS
STRASKLPLQ ESKSKFQREM SNSFVSSHEM SDISLSNSAM PKFSASSMTK LPQQAGNAVL
FHFQERKPQN LSPEIEKLCF TCSEEKPKSS NYKKVDFFIR NSECKKEVDF SMYHPDDEAD
EMKSLLGIFD GIF
//
