ID A0A096MWI3_PAPAN Unreviewed; 1256 AA.
AC A0A096MWI3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Calcium dependent secretion activator 2 {ECO:0000313|Ensembl:ENSPANP00000004239.2};
GN Name=CADPS2 {ECO:0000313|Ensembl:ENSPANP00000004239.2};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000004239.2, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000004239.2, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000004239.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A096MWI3; -.
DR Ensembl; ENSPANT00000008580.3; ENSPANP00000004239.2; ENSPANG00000016310.3.
DR eggNOG; KOG3543; Eukaryota.
DR GeneTree; ENSGT00590000083094; -.
DR HOGENOM; CLU_007068_1_0_1; -.
DR Proteomes; UP000028761; Chromosome 4.
DR Bgee; ENSPANG00000016310; Expressed in cerebellum and 64 other cell types or tissues.
DR ExpressionAtlas; A0A096MWI3; baseline.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR CDD; cd01234; PH_CADPS; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033227; CAPS.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR PANTHER; PTHR12166:SF7; CALCIUM-DEPENDENT SECRETION ACTIVATOR 2; 1.
DR Pfam; PF06292; MUN; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01145; DUF1041; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 351..465
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 488..591
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 880..1011
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 143602 MW; A90C96C0A0776D25 CRC64;
MLDPSSSEEE SDEGLEEESR DVLVAAGGSQ RAPPAPTREG RRDAPGRAGG GGGAARSVSP
SPSVLSEGRD EPERQLDDEQ ERRIRLQLYV FVVRCIAYPF NAKQPTDMAR RQQKLNKQQL
QLLKERFQAF LNGETQIVAD EAFCNAVRSY YEVFLKSDRV ARMVQSGGCS ANDFREVFKK
NIEKRVRSLP EIDGLSKETV LSSWIAKYDA IYRGEEDLCK QPNRMTLSAV SELILSKEQL
YEMFQQILGI KKLEHQLLYN ACQLDNADEQ AAQIRRELDG RLQLADKMAK ERKFPKFIAK
DMENMYIEEL RSSVNLLMAN LESLPVSKGG PEFKLQKLKR SQNSAFLDIG DENEIQLSKS
DVVLSFTLEI VIMEVQGLKS VAPNRIVYCT MEVEGEKLQT DQAEASRPQW GTQGDFTTTH
PRPVVKVKLF TESTGVLALE DKELGRVILY PTSNSSKSAE LHQMVVPKNS QDSDLKIKLA
VRMDKPAHMK HSGYLYALGQ KVWKRWKKRY FVLVQVSQYT FAMCSYREKK SEPQELMQLE
GYTVDYTDPH PGLQGGRMFF NAVKEGDTVI FASDDEQDRI LWVQAMYRAT GQSYKPVPAI
QTQKLNPKGG TLHADAQLYA DRFQKHGMDE FISANPCKLD HAFLFRILQR QTLDHRLNDS
YSCLGWFSPG QVFVLDEYCA RYGVRGCHRH LCYLTELMEH SENGAVIDPT LLHYSFAFCA
SHVHGNRPDG IGTVSVEEKE RFEEIKERLS SLLENQISHF RYCFPFGRPE GALKATLSLL
ERVLMKDIAT PIPAEEVKKV VRKCLEKAAL INYTRLTEYA KIEETMNQAS PARKLEEILH
LAELCIEVLQ QNEEHHAEAF AWWPDLLAEH AEKFWALFTV DMDTALEAQP QDSWDSFPLF
QLLNNFLRND TLLCNGKFHK HLQEIFVPLV VRYVDLMESS IAQSIHRGFE QETWQPVNNG
SATSEDLFWK LDALQMFVFD LHWPEQEFAH HLEQRLKLMA SDMLEACVKR TRTAFELKLQ
KASKTTDLRI PASVCTMFNV LVDAKKQSTK LCALDGGQEF GSQWQQYHSK IDDLIDNSVK
EIISLLVSKF VSVLEGVLSK LSRYDEGTFF SSILSFTVKA AAKYVDVPKP GMDLADTYIM
FVRQNQDILR EKVNEEMYIE KLFDQWYSSS MKVICVWLTD RLDLQLHIYQ LKTLIKIVKK
TYRDFRLQGV LEGTLNSKTY DTVHRRLTVE EATASVSEGG GLQGITMKDS DEEEEG
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