GenomeNet

Database: UniProt
Entry: A0A096N845_PAPAN
LinkDB: A0A096N845_PAPAN
Original site: A0A096N845_PAPAN 
ID   A0A096N845_PAPAN        Unreviewed;       816 AA.
AC   A0A096N845;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSPANP00000008770};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSPANP00000008770};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000008770, ECO:0000313|Proteomes:UP000028761};
RN   [1] {ECO:0000313|Ensembl:ENSPANP00000008770, ECO:0000313|Proteomes:UP000028761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A.,
RA   Aqrawi P.A., Arias F.A., Attaway T.A., Awwad R.A., Babu C.B.,
RA   Bandaranaike D.B., Battles P.B., Bell A.B., Beltran B.B.,
RA   Berhane-Mersha D.B., Bess C.B., Bickham C.B., Bolden T.B.,
RA   Carter K.C., Chau D.C., Chavez A.C., Clerc-Blankenburg K.C.,
RA   Coyle M.C., Dao M.D., Davila M.L.D., Davy-Carroll L.D., Denson S.D.,
RA   Dinh H.D., Fernandez S.F., Fernando P.F., Forbes L.F., Francis C.F.,
RA   Francisco L.F., Fu Q.F., Garcia-Iii R.G., Garrett T.G., Gross S.G.,
RA   Gubbala S.G., Hirani K.H., Hogues M.H., Hollins B.H., Jackson L.J.,
RA   Javaid M.J., Jhangiani S.J., Johnson A.J., Johnson B.J., Jones J.J.,
RA   Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K., Kovar C.K.,
RA   Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA   Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA   Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA   Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA   Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA   Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P.,
RA   Perez Y.P., Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q.,
RA   Rouhana J.R., Ruiz M.R., Ruiz S.-J.R., Saada N.S., Santibanez J.S.,
RA   Scheel M.S., Schneider B.S., Simmons D.S., Sisson I.S., Tang L.-Y.T.,
RA   Thornton R.T., Tisius J.T., Toledanes G.T., Trejos Z.T., Usmani K.U.,
RA   Varghese R.V., Vattathil S.V., Vee V.V., Walker D.W.,
RA   Weissenberger G.W., White C.W., Williams A.W., Woodworth J.W.,
RA   Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N., Nazareth L.N.,
RA   Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT   "Whole Genome Assembly of Papio anubis.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPANP00000008770}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPANP00000008770}.
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DR   EMBL; AHZZ01064113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01064114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01064115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01064116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHZZ01064117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003907245.1; XM_003907196.3.
DR   Ensembl; ENSPANT00000026106; ENSPANP00000008770; ENSPANG00000022958.
DR   GeneID; 101013373; -.
DR   CTD; 53373; -.
DR   GeneTree; ENSGT00530000063660; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   Proteomes; UP000028761; Chromosome 11.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028761};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    107    129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    235    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    300    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    445    465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    507    526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    570    594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    666    691       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      108    330       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      441    690       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   816 AA;  94185 MW;  D770F0A9190F19E5 CRC64;
     MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP SLSSEGGSSP
     SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY LFAHNHLFYL MELATALLLL
     LLSLCEAPAV PALRLGIYVH ATLELFALMV VVFELCMKLR WLGLHTFIRH KRTMVKTSVL
     VVQFVEAIVV LVRQMSHVRV TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL
     FFMIIFAILG FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF
     IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLV SQRRPAGISY
     RQFEGLMRFY KPRMSARERY LTFKALNQND TPLLSLKDFY DIYEVAALKW KAKKNREHWF
     DELPRTALLI FKGINILVKS KAFQYFMYLV VAVNGVWILV ETFMLKGGNF FSKHVPWSYL
     VFLTIYGVEL FLKVAGLGPV EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP
     LQLLRLFKLK ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT
     STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY IIMEGVTSQT
     SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN QDSEVDGGIT LEKEISKEEL
     VAVLELYREA QGASSDVTRL LETLSQMERY QQRSMVFLGR RSRTKSDLSL KMYQEEIQEW
     YEEHAREQEQ QRQLSSSAAP ATQQPPSSRQ RSQTVT
//
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