ID A0A096NG50_PAPAN Unreviewed; 3959 AA.
AC A0A096NG50;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Dynein axonemal heavy chain 12 {ECO:0000313|Ensembl:ENSPANP00000011912.3};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSPANP00000011912.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000011912.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000011912.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000011912.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 9555.ENSPANP00000011912; -.
DR Ensembl; ENSPANT00000027285.3; ENSPANP00000011912.3; ENSPANG00000013369.3.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154280; -.
DR HOGENOM; CLU_000038_1_1_1; -.
DR OMA; CIEWQRY; -.
DR Proteomes; UP000028761; Chromosome 2.
DR Bgee; ENSPANG00000013369; Expressed in testis and 34 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761}.
FT DOMAIN 1268..1407
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1903..2072
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 602..662
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 731..759
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2747..2812
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3959 AA; 453988 MW; E85A4FE531F85ABC CRC64;
MSDANKAAIA AEKEALNLKL SPIVHLPENI GVDTPTQSKL LKYRRSKEQQ QKINQLVIDG
AKRNLDRTLD KRTPLLPPPD YPQTMTSEIK KKGFNYIYMK QCVESSPIVP IQQEWLDHML
RLIPESLKEG KEREELLESL INEVSSDFEN SMKRYLVQSV LVKPPVKWLE DEGGPLPESP
VGLDYSNPWR SSYVQARNQI FSNLHIVHPT MKMLLDLGYT TFADTVLLDF TGIRAKGPID
CESLKTDLSI QTRKAEEKIM NTWYPKVINL FTKKEALEGV KPEKLDAFYS CVSTLMSNQL
KDLLRRTVEG FVKLFDPKDQ ERLPIFKIEL TFDDDKMEFY PTFQDLEDNI LSLVERIAEA
LQNVQTVPSW LSGTSTPVNL DTELPEHVLH WAVDTLKAAI HRNLEGARKH YETYVEKYNW
LLDGTAVENI ETFQTEDHTF DEYTEFIEKF FSLASEIMLL PQWIHYPMVR LDCEDLKTGL
TNKAKAFANI LLNDIASKYR KENERICSEF EAIKEHALKV PETTEEMMDL ISYVEKARTT
GIEELILRIQ ESKRQMSYFL DVFLFPQEDL ALNATVLMWP KKINPIFDEN DELIENAKHK
KENELMAKRE KLILEIEKES RRMEEFTEFA ELERMQQYVT DVRQLQKRIQ ESEEAVQFIN
KEEELFKWEL TKYPELDKLK VNIEPYQKFF NFVLKWQRSE KRWMDGGFLD LNGESMEADV
EEFSREIFKT LKFFQTKLKK ELQEKRKAAR KRSLEEEKIE EEPKENPTLT MCSTVMEQIK
AFREYIPTVS ILCNPGMRAR HWKQMSEIVG YDLTPDSGTT LRKVLKLNLT PYLEQFEVIS
AGASKEFSLE KAMNTMIGTW DDIAFHISLY RDTGVCILSS VDEIQAILDD QIIKTQTMRG
SPFIKPFEHE IKAWEDRLIR IQETIDEWLK VQAQWLYLEP IFCSEDIMQQ MPEEGRQFQT
VDRHWRDIMK FCAKDPKVLA ATSLTGLLEK LQNCNELLEK IMKGLNAYLE KKRLFFPRFF
FLSNDEMLEI LSETKDPLRV QPHLKKCFEG IAKLEFLPNL DIKAMYSSES ERVELIALIS
TSAARGAVEK WLIQVEDLML RSIHDVIAAA RLAYPESARR DWVREWPGQV VLCVSQMFWT
SETQEVISGG TEGLKKYYKE LQNQLNEIVG LVRGKLSKQT RTTLGALVTI DVHARDVVMD
MIEMGVSHDT DFQWLAQLRY YWENENARVR IINCNVKYAY EYLGNSPRLV ITPLTDRCYR
TLIGAFYLNL GGAPEGPAGT GKTETTKDLA KALAVQCVVF NCSDGLDYLA MGKFFKGLAS
SGAWACFDEF NRIELEVLSV VAQQILCIQR AIQQKLDVFV FEGTELKLNP NCFVAITMNP
GYAGRSELPD NLKVLFRTVA MMVPNYALIA EISLYSYGFL NAKPLSVKIV MTYRLCSEQL
SSQFHYDYGM RAVKAVLVAA GNLKLKYPNE NEDILLLRSI KDVNEPKFLS HDIPLFNGIT
SDLFPGIKLP EADYHEFLEC AHEACNVHNL QPVKFFLEKI IQTYEMMIVR HGFMLVGEPF
AAKTKVLHVL ADTLSLMNEH GYGEEEKVIY RTVNPKSITM GQLFGQFDPV SHEWTDGIVA
NTFREFALSE TSDRKWVVFD GPIDTLWIES MNTVLDDNKK LCLMSGEIIQ MSPQMSLIFE
TMDLSQASPA TVSRCGMIYL EPSQLGWEPL VSSWLNSLKG PLCEPEHQAL LKGLFAWLIP
PSLKQRKKKC KELIPTSNSN VVVSLTRLFE VLLCNVVEND PTSKHIRVWI MACFIFSLIW
SIGGSCDTDG RHVFDAFIRL IILGKDEENP VPDSVGKWEC PFDEKGLVYD YMYELKNKGR
WVHWNELIKN TNLGDKQIKI QDIIVPTMDT IRYTFLMDLS ITYAKPLLFV GPTGTGKSVY
VKDKLMNHLE KDKYFPFYVN LSARTSANQV QNIIMARLDK RRKGVFGPPM GKKCIIFIDD
MNMPALEKYG AQPPIELLRQ FFDCGHWYDL KDTSKITLVD IELIAAMGPP GGGRNPVTPR
CIRHFNVCSI NSFSDETMVR IFSSIVAFYL RTREFPPEYF VIGNQIVNGT MEIYKQSVEN
LLPTPTKSHY TFNLRDFSRV IRGCLLIERD AVASKHTMIR LFVHEVLRVF YDRLINDDDR
RWLFQLTKTV IKDHFKESFD SIFSHLRKQN APVTEEDLRN LMFGDYMNPD LEGDDRVYIE
IPNILHFSDV VDQCLDEYNQ THKTRMNLVI FRYVLEHLSR ICRVLKQSGG NALLVGLGGS
GRQSLTRLAT SMAKMHIFQP EISKSYGMNE WREDMKGLLR NVGMRGQKTV FLITDTQIKE
EAFLEDIDSV LNTGEVPNIF AADEKQEVME GVRPVAQAGS KHDELSPLAL FAFFVNRCKD
NLHVVVAFSP IGDAFRNRLR QFPSLINCCT IDWFQSWPED ALERVAVKFL ETLELTEVER
QEIVPICKHF HTSIMDLSER FLHELGRHNY VTATSYLELI GSFRQLLTKK RQAVMEAKQR
YVNGLDKLAF AESQVGEMQM ELVELQPKLE EAKIENANMM QVIEIESVQV EAKRQFVKLD
EEVASGKADE AQALKNECES DLAEAIPALE AALSALDTLK PADITIVKSM KNPPSGVKLV
MAAVCVMKDI KPEKISDPSG TGGKILDYWG PSKKLLGDMN FLRDLKEYDK DNIPVTVMQK
IRSEYLTNPE FDPPKVAKAS SAAEGLCKWI MAMEVYDRVA KVVAPKKARL TEAQKSLAET
MELLNQKRAE LAEVEHHLEN LQMTFLEKTE EKAALEDQVE LCAKKLERAS QLIGGLGGEK
SRWAQAADDL QITYENLTGD VLVSAGVIAY LGAFTSGFRE TCTKDWSMLC KKKKIPCSEE
FLLSKTLGDP VQIRAWNIAG LPTDRFSIDN GVIVNNSRRW PLMIDPQGQA NKWIKNSEKE
NQLSVIKLSD SDYMRTLENC IQFGTPLLLE NVGEELDPSL EPLLLRQTFK QGGIDCIRLG
EVIIEYSFDF KFYITTKLRN PHYMPELATK VSLLNFMITP EGLEDQLLGI VVAKERPELE
EERNALILQS AANKKQLKDI EKKILETLSS SEGNILEDES AIKVLDSAKM MSNEITKKQQ
IAEKTELKIA ESREGYRPIA KHSSVLFFSI ADLANIDPMY QYSLTWFVNL YINSIHDSNK
SKILEKRLRY LNDHFTYNLY CNICRSLFEK DKLLFSFLLC ANLLLARKEI EYQELMFLLT
GGVSLKSAEK NPDPTWLQDK SWEEICRASE FPAFRGLRQH FCEHIYEWEI YDSKEPHNAK
FPAPMDKNLK ELQKIIILRC LRPDKITPAI TNYVTDKLGK KFVEPPPFDL TKSYLDSNCT
IPLIFVLSPG ADPMASLLKF ANDKSMSGNK FQAISLGQGQ GPVAAKMIKA AIEEGTWVCL
QNCHLAVSWM PMLEKICEDF TSETCNSSFR LWLTSYPSPK FPVTILQNGV KMTNEPPTGL
RLNLLQSYLT DPVSDPEFFK GCRGKELAWE KLLFGVCFFH ALVQERKKFG PLGWNIPYGF
NESDLRISIR QLQLFINEYD TVPFEAISYL TGECNYGGRV TDDWDRRLLL TMLADFYNLS
IVENPHYKFS PSGNYFAPPK GTYEDYIEFI KKLPFTQHPE IFGLHENVDI SKDLQQTKTL
FESLLLTQGG SKQTGAAGST DQILLEIAKD ILNKLPSDFD IEMALQKYPV RYEESMNTVL
VQEMERFNNL IITIRNSLRD LEKAIKGVVV MDSALEALSS SLLVGKVPEI WAKRSYPSLK
PLGSYTTDFL ARLNFLQDWY NSGKPCVFWL SGFFFTQAFL TGAMQNYARK YTTPIDLLGY
EFEVIPSDTS DTSPDDGVYI HGLYLDGARW NRQSGLLAEQ HPKLLFDLMP IIWIKPTQKS
QIIKSDAYVC PLYKTSERKG TLSTTGHSTN FVIAMLLKTD QPTEHWIKRG VALLCQLDD
//
